A5104195562- Anorectal Disease Treatments and Outcomes
- Pelvic floor disorders treatments
- Acupuncture Treatment Research Studies
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Inflammatory Bowel Disease
- Research studies in Vietnam
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Wound Healing and Treatments
- Circular RNAs in diseases
- Gastrointestinal motility and disorders
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- RNA modifications and cancer
- Metal-Organic Frameworks: Synthesis and Applications
- Diverticular Disease and Complications
- Ginseng Biological Effects and Applications
- Music Therapy and Health
- Biofield Effects and Biophysics
- Pressure Ulcer Prevention and Management
- Enhanced Recovery After Surgery
Shanghai University of Traditional Chinese Medicine
2011-2025
Shenyang Anorectal Hospital
2023
Harbin Institute of Technology
2021
Intas Pharmaceuticals (India)
2018
Shanghai Traditional Chinese Medicine Hospital
2018
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2007-2013
Abstract The herbal sitz bath formula, as a complementary therapy, effectively alleviates postoperative wound pain and accelerates healing time in patients with perianal abscesses. To investigate its mechanism of action, this study conducted 16S rRNA gene sequencing bioinformatics analysis on exudate samples from after abscess surgery. Patients were randomly divided into two groups: one receiving the an adjunctive therapy other without therapy. Samples collected first eighth days surgery to...
Abstract The PI3K/AKT/mTOR signaling pathway is constitutively active in PTEN-deficient cancer cells, and its targeted inhibition has significant anti-tumor effects. However, the efficacy of therapies often limited due to drug resistance. relevant pathways cells treated with PI3K/mTOR inhibitor BEZ235 were screened using a phosphokinase array, further validated following treatment multiple inhibitors or AKT knockdown. correlation between PTEN expression levels STAT3 kinase phosphorylation...
Colorectal cancer (CRC) is a major global health issue, with rising incidence and mortality rates. Dietary factors, especially whole grains consumption, are critical in determining CRC risk. Understanding deaths disability-adjusted life years (DALYs) related to low diets important for prevention. The purpose of the study investigate temporal geographic trends DALYs attributable diet at global, regional, national levels from 1990 2021. data on burden 2021 were extracted Global Burden Diseases...
Abstract Aimed to clarify the effect of quercetin and its derivatives on wound healing in animal experiments. PubMed, Embase, Science Direct, Web Science, SinoMed, Vip Journal Integration Platform, China National Knowledge Infrastructure WanFang databases were searched for experiments investigating April 2023. The Review Manager 5.4 software was used conduct meta‐analysis. Eighteen studies enrolled this article. According SYRCLE's RoB tool assessment, these exposed relatively low...
Primary colon adenocarcinoma is responsible for high rates of mortality worldwide. The late diagnosis and lack reliable biomarkers therapeutic targets forms a bottleneck in the treatment cancer. In present study, potential an important microRNA (miR), namely miR‑145, was investigated primary cells. results revealed that expression miR‑145 significantly (P<0.05) downregulated cells ectopic cancer inhibited proliferation by promoting apoptosis SW480 Furthermore, bioinformatics analysis exerts...
The pathogenesis of the immune regulation dysfunction is unclear. Bcl2-like protein 12 (Bcl2L12) has suppression function. This study tests a hypothesis that tumor necrosis factor (TNF) increases Bcl2L12 to suppress expression interleukin (IL) 10 in peripheral B cells patients with inflammatory bowel disease (IBD). In this study, blood samples were collected from IBD and healthy controls. isolated samples. IL-10 was analyzed by quantitative reverse transcription polymerase chain reaction...
Hemorrhoids are one of the most common conditions that lead to surgery, and until now surgical hemorrhoidectomy has been major effective treatment. Post-operative pain from experienced by thousands patients remains a inconvenience operation.This study evaluates clinical efficacy pestle needle therapy, an acupoint stimulation method, for relief post-hemorrhoidectomy pain.This was single-center, patient-assessor-blinded randomized controlled trial with 154 receiving Milligan surgery. Eligible...
Abstract Bruceine D (BD) from Brucea javanica (L) exerts an antitumor effect in several human cancers. At present, it has not been reported whether BD inhibits the malignancy of colorectal cancer (CRC) cells. Therefore, investigating role and regulatory mechanisms CRC is main thrust this study. Effect on cell viability, proliferation, apoptosis, invasion, autophagy was determined by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide, 5‐ethynyl‐2′‐deoxyuridine, flow cytometry,...
In order to observe the clinical therapeutic effects of Yiqi Kaimi Prescription and biofeedback therapy on treating constipation with deficiency spleen qi, 30 cases in control group were given oral administration Prescription, combination anus-lifting exercise; treatment basis afore mentioned methods for group. The TCM symptom scores anorectal pressures before after observed evaluated. There significant differences scores, pressure, recovery rate treatment. group, total was 86.66%, while it...
Anal sphincter injury leads to damage the anal structure and functions has been identified as a major risk factor for fecal incontinence. Bone marrow mesenchymal stem cells (BMSCs) with capacities of multidifferentiation, paracrine, low immunogenicity have widely used in tissue repair regeneration. The primary objective this research was compare effects different injection therapies BMSCs on injured sphincters. Ninety-six Sprague-Dawley female rats were randomly divided into four groups (n =...
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by dysregulated immune responses in the gastrointestinal tract. One intriguing aspect of IBD potential involvement ferroptosis, but mechanism remains incompletely understood. In this study, 27 ferroptosis-related genes (FRGs) were identified differentially expressed between and non-IBD control samples. We used CIBERSORT to compare alterations mucosal microenvironment above two group samples, found that M1...
Bone marrow mesenchymal stem cells (BMSCs) and acupuncture are known to mitigate tissue damage. This study aimed investigate the therapeutic effects of combined electroacupuncture (EA) stimulation BMSC injection in a rat model anal sphincter injury-induced faecal incontinence (FI).60 Sprague-Dawley rats were randomly divided into five groups: sham-operated control, FI, FI+EA, FI+BMSC, FI+BMSC+EA. The anorectal tissues collected on days 1, 3, 7 14. Repair injured was compared using...
The aim of the present study to evaluate application sentinel lymph node (SLN) pathology in rectal cancer using ex vivo mapping and investigate incidence prognostic value occult SLN metastasis routine node-negative specimens. Specimens (n=117) were examined a combination mapping. inspected SLNs further treated with immunohistochemical staining for foci. log-rank test was used assess survival. 112 included specimens total number 212, resulting an identification rate 95.7% (112/117). status...
Objective. This study was aimed at comparing the clinical efficacy of acupuncture and moxibustion on irritable bowel syndrome complicated with diarrhea (IBS-D) in adults providing guidance for treatment. Methods. PubMed, The Cochrane Library, Embase, CBM, CNKI, VIP Wanfang databases were searched to obtain randomized controlled trials (RCTs) treatment IBS-D published from establishment database August 5, 2021. Relevant data extracted assess risk bias included studies, statistical software...
Abstract The development of ulcerative colitis (UC) results from many factors such as intestinal microflora regulatory genes and immune environment. Studies in humans research animals suggest mucosa health is associated with gut microbiota, but the detailed regulation mechanism currently unknown. Baicalin, a flavonoid, has been reported to play an anti-inflammatory role several diseases, its effect on UC microbiota still unclear. In this study, we characterized protective effects baicalin...