A5103096848- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Urological Disorders and Treatments
- Histone Deacetylase Inhibitors Research
- Gestational Diabetes Research and Management
- RNA Interference and Gene Delivery
- Fungal Plant Pathogen Control
- Plant Disease Resistance and Genetics
- Animal Nutrition and Physiology
- Birth, Development, and Health
- Antimicrobial Peptides and Activities
- Urinary and Genital Oncology Studies
- Hippo pathway signaling and YAP/TAZ
- Urologic and reproductive health conditions
- RNA Research and Splicing
- Endometrial and Cervical Cancer Treatments
- Sirtuins and Resveratrol in Medicine
- Phytochemical compounds biological activities
- Bacterial biofilms and quorum sensing
- Viral-associated cancers and disorders
- Moringa oleifera research and applications
- Antimicrobial agents and applications
- Pregnancy and preeclampsia studies
Sichuan Agricultural University
2024-2025
Huazhong University of Science and Technology
2025
Central Hospital of Wuhan
2025
First Affiliated Hospital of Bengbu Medical College
2022
North China University of Science and Technology
2020-2022
North China University of Science and Technology Affiliated Hospital
2020-2021
China Medical University
2013
Due to the high mortality rate in chicks caused by pullorum disease (PD) and drawbacks of antibiotic resistance, poultry industry is increasingly interested using natural herbal antimicrobial agents as alternatives, with cinnamaldehyde (CA) being a focus due its multitarget synergistic effects. This study aimed evaluate effects oral administration CA on restoring intestinal physical integrity, microbial barrier, metabolism laboratory model Salmonella (S. pullorum) infection chicks....
Background: Diabetic retinopathy (DR) is a microangiopathy resulting from diabetes mellitus. Studies on vitreous samples have shed insights into the etiology of DR and highlighted role molecular targets in treatment. The present study probed extracellular matrix metalloproteinase inducer (EMMPRIN) by examining its influence inflammation, angiogenesis, metalloproteinases (MMPs), blood-retina barrier injury. Methods: After induction rats through streptozotocin injection, SP-8356 (an inhibitor...
MicroRNA (miR)‑126 is known to inhibit inflammatory responses in various inflammatory‑related diseases, but its role during the cerebral ischemia/reperfusion (I/R) injury remains unknown. The present study aimed examine interaction between miR‑126 and RAB3A interacting protein (RAB3IP), explore potential protective effects I/R injury. human neuroblastoma cell line SH‑SY5Y was cultured an oxygen‑glucose deprivation/reoxygenation (OGD/R) environment simulate assess expression viability. cells...
<b><i>Objectives:</i></b> In this study, we aimed to compare the levels of maternal blood lipids, placental and venous lipid transporters, inflammatory factor receptors in pregnant women with without gestational diabetes mellitus (GDM). We also figure out relationship between these values neonatal weight. <b><i>Methods:</i></b> Fifty GDM under glucose control belong case group, 50 normal tolerance concurrent delivery group. Fasting was taken 2...
Terbinafine inhibits the proliferation of many types cancer cells, but underlying mechanism remains to be determined.By computer simulation, we found that kinase suppressor Ras 1 (KSR1) is a possible target terbinafine.Treatment human oral squamous cell carcinoma (OSCC) KB cells with either terbinafine or siRNA knockdown KSR1 reduced and induced apoptosis, which was accompanied by suppression Raf-MEK-ERK pathway.In vivo, expression significantly associated clinical staging OSCC smoking habit...
Background Staphylococcus aureus ( S. ) biofilm associated infections are prevalent and persistent, posing a serious threat to human health causing significant economic losses in animal husbandry. Nanoemulsions demonstrate potential the treatment of bacterial due their unique physical, chemical biological properties. In this study, novel cinnamaldehyde nanoemulsion with ability penetrate structures eliminate biofilms was developed. Methods The formulation (Cin-NE) combined rhamnolipid (RHL)...
MicroRNA‑199a‑3p (miR‑199a‑3p) is aberrantly expressed in various types of cancer where it exhibits a tumor suppressive role. However, the biological role miR‑199a‑3p ovarian (OC) remains unclear. The present study aimed to investigate whether was suppressor OC and identify possible mechanisms. It found that expression significantly downregulated tissues blood samples patients with OC, as well three cell lines. In addition, its low closely associated International Federation Gynecology...
Objective: The present study aimed to explore the function of sirtuin 2 (SIRT2) on cell proliferation, apoptosis, rat sarcoma virus (RAS)/ extracellular signal-regulated kinase (ERK) pathway in endometrial cancer (EC). Methods: SIRT2 expression human EC lines and (uterine) epithelial (HEEC) line was assessed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) western blot. knock-down control plasmids were transfected into HEC1A cells, respectively; overexpression...
Abstract Background This study aimed to detect the eukaryotic initiation factor 3B (EIF3B) expression and explore its correlation with clinical features prognosis in epithelial ovarian cancer (EOC) patients. Methods A total of 230 primary EOC patients underwent surgery treatment were retrospectively reviewed. Immunohistochemical (IHC) assay was used determine EIF3B tumor adjacent tissue specimens all According IHC score, classified as low high expression, latter further divided into 3...
To investigate the effect of pirfenidone for reducing urethral stricture following injury in rats and explore possible mechanism.Thirty male SD were randomly assigned into negative control group, positive group (n=10). In groups, subjected to incision posterior cavernous body followed by daily intraperitoneal injection (100 mg/kg) an equivalent volume solvent, respectively. The given injections solvent without injury. At two weeks after modeling, retrograde urethrography was performed...
Ovarian cancer (OC) has been identified to have the highest mortality rate among gynecological tumors. Most patients are diagnosed at an advanced stage because of its asymptomatic nature and a lack effective early diagnostic methods. Advanced-stage cells prone metastasis which reduces efficacy standard therapies. Thus, we evaluated effect different concentrations radix tetrastigma hemsleyani flavone (RTHF) on SKOV3 OC cells. Our findings indicated significant inhibition in cell...