A5100638188- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Reproductive Biology and Fertility
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Endometriosis Research and Treatment
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Breast Cancer Treatment Studies
- MicroRNA in disease regulation
- Acupuncture Treatment Research Studies
- Cancer, Lipids, and Metabolism
- Sperm and Testicular Function
- Epigenetics and DNA Methylation
- Advanced X-ray and CT Imaging
- Cancer Mechanisms and Therapy
- Animal Virus Infections Studies
- NF-κB Signaling Pathways
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
University of Science and Technology of China
2020-2025
Hubei University of Science and Technology
2023-2025
Shanxi Academy of Medical Sciences
2025
Shanxi Medical University
2025
Shanghai Chest Hospital
2023-2024
Shanghai Jiao Tong University
2007-2024
Universitätsklinikum Tübingen
2017-2024
Zhuhai People's Hospital
2024
Nanjing Drum Tower Hospital
2011-2024
Ruijin Hospital
2014-2023
The problem of antibiotic abuse and drug resistance is becoming increasingly serious. In recent years, polydopamine (PDA) nanoparticles have been recognized as a potential antimicrobial material for photothermal therapy (PTT) due to their excellent conversion efficiency unique ability. PDA capable rapidly converting light energy into heat under near-infrared (NIR) irradiation kill bacteria efficiently. order solve the PDA's tendency aggregate precipitate, this study improved its stability by...
Spermiogenesis is a unique process in mammals during which haploid round spermatids mature into spermatozoa the testis. Its successful completion necessary for fertilization and its malfunction an important cause of male infertility. Here, we report high-confidence identification 2116 proteins mouse germ cells undergoing spermiogenesis: 299 these were testis-specific 155 novel. Analysis showed many possibly functioning processes spermiogenesis. Of 84 annotated to be involved vesicle-related...
Research questionDoes adenomyosis affect IVF independent of decreased ovarian reserve, and what are the characteristics outcome ultra-long gonadotrophin-releasing hormone (GnRH) agonist protocol in adenomyosis?DesignObservational cohort study three groups patients undergoing first cycle treatment with normal reserve: (A) 362 using GnRH protocol; (B) 127 long (C) 3471 tubal infertility protocol.ResultsCompared B C, number oocytes retrieved group A decreased, gonadotrophin dosage duration were...
Young onset breast cancer, diagnosed in women under 50, is known for its aggressive nature and challenging prognosis. Precisely forecasting axillary lymph node metastasis (ALNM) essential customizing treatment plans enhancing patient results. This research sought to create verify a clinical-radiomics nomogram that combines radiomic features from Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) with standard clinical predictors improve the accuracy of predicting ALNM young...
Objective: Haprolid, a novel compound extracted from Myxobacterium, has been proven to possess selective toxicity towards various tumor cells, effectively inhibiting the growth of hepatocellular carcinoma (HCC). However, underlying molecular mechanism remains unclear. Methods: To identify differentially expressed proteins (DEPs), isobaric tags for relative and absolute quantitation (iTRAQ) were employed. The clinical significance DExH-Box Helicase 9 (DHX9) was determined using tissue...
Objective . The aim of this study was to investigate the potential role IL-10 in regulating receptivity marker HOXA10 endometrium women with adenomyosis. Methods expression levels IL-10, HOXA-10, STAT3, and p-STAT3 adenomyosis controls were examined by means western blotting immunohistochemistry. protein Ishikawa cells treated rIL-10 blotting. attachment rate BeWo cell spheroids expressed as a percentage total number spheroids. Results group significantly lower than those control group,...
Abstract Background and Aim Cholangiocarcinoma has an unimproved prognosis. Interleukin 6 (IL‐6) oncogenic potential in some cancer diseases. However, the role of IL‐6 cholangiocarcinoma carcinogenesis is not well understood. The current study investigated signaling efficacy siltuximab treatment on vitro vivo . Methods expression was analyzed human cell lines murine tissues, using reverse transcription real‐time polymerase chain reaction immunohistochemistry. In addition, effect anti‐IL‐6...
Decidualization is a prerequisite for successful implantation and the establishment of pregnancy. A critical role impaired decidualization in subfertility has been established. In human endometrial stromal cells (hESCs), Krüppel-like factor 12 (KLF12) Nur77 are novel regulators decidualization. We investigated whether KLF12 hESCs recurrent failure (RIF) patients.Endometrial tissues were collected from RIF patients (n = 34) fertile controls 30) vitro analysis. Primary isolated used to...
Abstract The contribution of cellular senescence to the behavioral changes observed in elderly remains elusive. Here, we that aging is associated with a decline protein phosphatase 2A (PP2A) activity brains zebrafish and mice. Moreover, drugs activating PP2A reversed age‐related changes. We developed transgenic model decrease brain through knockout ppp2r2c gene encoding regulatory subunit PP2A. Mutant fish exhibited phenotype old animals premature accumulation neural cells positive for...
Decidualization is a prerequisite for successful implantation and the establishment of pregnancy. Krüppel-like factor 12 (KLF12) negative regulator endometrial decidualization in vitro. We investigated whether KLF12 was associated with impaired under conditions repeated failure (RIF).Uterine tissues were collected from mouse model early pregnancy artificial immunohistochemistry, Western blot real-time PCR analysis. Reporter gene assays, chromatin immunoprecipitation-PCR avidin-biotin...
Problem To define a more precise parameter for better understanding of natural killer ( NK ) cells and its relation with regulatory T (Tregs) in women recurrent implantation failure RIF ). Method study The percentages CD 56+ cells, 57+ Foxp3+ the endometrium blood from 23 normal controls 32 were measured by immunocytochemistry flow cytometry. Results Women had significantly increased ratio to both P <.01) <.05), decreased percentage <.05). There was significant negative correlation...
Cholangiocarcinoma (CCA) has a poor prognosis and only limited palliative treatment options. The deficiency of adiponectin adenosine monophosphate-activated protein kinase (AMPK) signaling was reported in several malignancies, but the alteration these proteins CCA is still unclear.
Hepatocellular carcinoma (HCC) represents a major health burden with limited curative treatment options. There is substantial unmet need to develop innovative approaches impact the progression of advanced HCC. Haprolid novel natural component isolated from myxobacteria. has been reported as potent selective cytotoxin against panel tumor cells in recent studies including HCC cells. The aims this study are evaluate antitumor effect haprolid and understand its underlying molecular mechanisms....
Various X-ray imaging technologies like computed tomography (CT) and digital subtraction angiography (DSA) are widely used in transcatheter arterial embolization (TAE) therapy for treating hepatocellular cancer (HCC) patients. Although they display high-contrast imaging, have a few disadvantages, such as complex operation exposure to ionizing radiation. Thus, ultrasound (US) plays an important role medical diagnosis because of its advantages, simple fast operation, no radiation exposure,...
<b><i>Objectives:</i></b> In this study, we aimed to compare the levels of maternal blood lipids, placental and venous lipid transporters, inflammatory factor receptors in pregnant women with without gestational diabetes mellitus (GDM). We also figure out relationship between these values neonatal weight. <b><i>Methods:</i></b> Fifty GDM under glucose control belong case group, 50 normal tolerance concurrent delivery group. Fasting was taken 2...
The heterotrimeric G-protein pathway controls numerous cellular processes, including proliferation, differentiation, migration, membrane trafficking, and embryonic development. Regulator of signaling (RGS) proteins are known to function at the level. Here, functional role a novel RGS protein, regulator 22 (RGS22), in testis was investigated mRNA protein levels. Our results demonstrate that RGS22 is testis-specific gene. However, significantly decreased expression found testes patients with...
This study investigated interobserver and intraobserver variability in radiation oncologists' definition of the tumor bed (TB) after breast-conserving surgery (BCS).The TB volume, CVS number surgical clips were not significantly related to variability. Moreover, no correlation was noted between CT slice thickness (Δinter, DSCinter) delineation, significant difference among three groups. The volume negatively correlated with Δinter. DSCinter improved increased decreased also patients a 3 5...