A5077728763- Neonatal Respiratory Health Research
- Immune cells in cancer
- Salivary Gland Disorders and Functions
- Immune Response and Inflammation
- PI3K/AKT/mTOR signaling in cancer
- Mesenchymal stem cell research
- Tracheal and airway disorders
- Cancer Mechanisms and Therapy
- FOXO transcription factor regulation
- Sinusitis and nasal conditions
- Medical Imaging and Pathology Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- COVID-19 Impact on Reproduction
- Extracellular vesicles in disease
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Complement system in diseases
- Inflammation biomarkers and pathways
- Pancreatic function and diabetes
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Planarian Biology and Electrostimulation
- Quinazolinone synthesis and applications
- Animal Virus Infections Studies
- Metabolism, Diabetes, and Cancer
Hainan University
2023-2025
National Taiwan Normal University
2012-2025
Qiqihar Medical University
2024
Ningbo No. 2 Hospital
2024
Shanghai Sixth People's Hospital
2020-2023
Shanghai Jiao Tong University
2020-2023
Jiangsu University
2018-2021
Zhejiang University
2015
First Affiliated Hospital of Chinese PLA General Hospital
2014
Abstract Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands lacrimal glands. Our previous studies showed that myeloid-derived suppressor cells (MDSCs) exhibited impaired immunosuppressive function during progression patients with SS mice experimental (ESS), but it remains unclear whether restoring the of MDSCs can effectively ameliorate development ESS. In this study, we found murine olfactory...
Olfactory ecto-mesenchymal stem cells (OE-MSCs) are a novel population of resident in the olfactory lamina propria with strong immunosuppressive function. Exosomes released by MSCs considered to carry various mRNAs, microRNAs and proteins from function as an extension MSCs. However, it remains unclear whether exosomes derived OE-MSCs (OE-MSCs-Exos) possess any immunoregulatory functions. In this study, we found that OE-MSCs-Exos possessed suppressive CD4+T cell proliferation, accompanied...
Abstract Extracellular matrix (ECM) assembly/disassembly is a critical regulator for airway epithelial development and remodeling. Airway organoid widely used in respiratory research, yet there limited study to indicate the roles mechanisms of ECM organization growth differentiation by using vitro system. Moreover, most current Matrigel-based organoids are basal-out orientation where accessing apical surface challenging. We present human apical-out biochemically defined hybrid hydrogel...
Although the expansion of myeloid-derived suppressor cells (MDSCs) has been reported in autoimmune disorders, it is largely unclear how MDSCs contribute to development primary Sjögren syndrome (pSS). In this study, we found significantly increased with gradually diminished suppressive capacity during disease mice experimental (ESS). The ligand for glucocorticoid-induced TNFR family-related protein (GITRL) was along ESS progression, whereas GITRL attenuate immunosuppressive function MDSCs....
We report the asymmetric total synthesis of optically active nervione in both (+) and (−) forms, a natural product initially isolated from Nervilia concolor 2022. Beginning with commercially available resorcinol, pure was synthesized 10 steps, employing combination ortho-directed strategies crucial late-stage, Lewis acid-mediated, highly diastereoselective reduction. Discrepancies observed circular dichroism (CD) spectra prompted reassignment nervione's absolute configuration (3S, 8R) to (3R, 8S).
Novel drugs are required for non-small cell lung cancer (NSCLC) treatment urgently.Repurposing old as new treatments is a practicable approach with time and cost savings.Some studies have shown that carrimycin, Chinese Food Drug Administration (CFDA)-approved macrolide antibiotic, possesses potent anti-tumor effects against oral squamous carcinoma.However, its detailed component underlying mechanisms in anti-NSCLC remain unknown.In our study, isovalerylspiramycin I (ISP-I) was isolated from...
Primary Sjögren’s syndrome (pSS) is a progressive systemic autoimmune disease characterized by lymphocytic infiltrates in exocrine glands, leading to the injury of salivary and lachrymal glands. Mesenchymal stem cells (MSCs) have been demonstrated exert great potential treatment various diseases. Although MSCs provide an effective therapeutic approach for SS treatment, underlying mechanisms are still elusive. Our previous study has shown reduced suppressive capacity myeloid-derived...
Lung cancer is a global health problem. The search for new therapeutic approaches the treatment of lung important. Here, we reported that AKT inhibitor perifosine and MEK\ERK MEK-162 synergistically induced cell (A549 H460 lines) growth inhibition apoptosis. combined efficiency was significantly higher than either agent alone. For molecular study, worked together to concurrently block AKT, mammalian target rapamycin (mTOR) complex 1 (mTORC1), MEK-ERK signalings in cells, while alone only...
Understanding disease-associated stem cell abnormality has major clinical implications for prevention and treatment of human disorders, as well regenerative medicine. Here we report a multifaceted study on airway epithelial cells in Tracheobronchopathia Osteochondroplastica (TO), an under-detected tracheobronchial disorder unknown etiology lack specific treatment. Epithelial squamous metaplasia heterotopic bone formation with abnormal cartilage proliferation calcium deposits are key...
Rhabdomyosarcoma (RMS) is a highly malignant and metastatic pediatric cancer that arises from the skeletal muscle. Recent studies have identified an important role of AKT signaling in RMS progression. In current study, we investigated activity perifosine, oral alkylphospholipid inhibitor, against human cells (RD Rh-30 lines) both vivo vitro, studied underlying mechanisms. We showed perifosine significantly inhibited cell growth concentration- time-dependent manners. Meanwhile, induced...
To further improve the understanding of paroxysmal nocturnal hemoglobinuria (PNH), we retrospectively analyzed and summarized clinical characteristics, treatment status, survival status patients with PNH in Zhejiang Province.
Sulfonamides are not only widely applied in clinics but also highly valued animal husbandry. Recently, it has become common for sulfonamide residues to exceed the standard limits food, which can affect human health. Current regulations limit these residues. Therefore, we constructed a new test method rapidly determine levels of Six sulfonamides were detected using latest called TLC-SERS, namely, sulfamethasone (A), sulfamethazine (B), sulfadoxine (C), sulfamethoxydiazine (D),...
Abstract It is largely unclear how MDSCs contribute to the development of primary Sjögren’s syndrome (pSS). In experimental SS (ESS) mice, were significantly increased but exhibited gradually diminished suppressive capacity during disease progression. The ligand for glucocorticoid-induced TNFR family-related protein (GITRL) was with pSS, and GITRL found down-regulate function while blocking GITR signal in restored their ameliorated ESS progression mice. pSS patients, expanded expressed lower...
Abstract Background Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltrates in exocrine glands. Mesenchymal stem cells (MSCs) have been proved to be effective the treatment of different diseases. Although MSC transplantation has demonstrated an therapeutic approach treat SS, underlying mechanisms are still elusive. Our previous study identified reduced suppressive capacity MDSCs advanced progression experimental (ESS). Methods The...
The airway epithelium is the footstone to maintain structure and functions of lung, in which resident basal cells (BCs) homeostasis functional regeneration epithelial barrier response injury. In recent clinical researches, transplanting BCs has shown great inspiring achievements therapy various lung diseases. this study, we report a noninvasive optical method activate for vivo by fast scanning focused femtosecond laser on active Ca 2+ signaling subsequent ERK Wnt pathways. photoactivated...