A5101573075- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Retinal Diseases and Treatments
- Prostate Cancer Treatment and Research
- Sepsis Diagnosis and Treatment
- Retinal and Optic Conditions
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Immune Cell Function and Interaction
- Medical Research and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Autoimmune Neurological Disorders and Treatments
- Retinal Development and Disorders
- Ocular Surface and Contact Lens
- Parvovirus B19 Infection Studies
- Cerebral Palsy and Movement Disorders
- Dialysis and Renal Disease Management
- Retinal Imaging and Analysis
- Insect symbiosis and bacterial influences
- Acupuncture Treatment Research Studies
- Memory Processes and Influences
- Long-Term Effects of COVID-19
- Intraocular Surgery and Lenses
- Autoimmune and Inflammatory Disorders Research
Princess Margaret Cancer Centre
2025
University Health Network
2025
Shandong Provincial Hospital
2012-2024
Shandong First Medical University
2021-2024
University of Pittsburgh
2009-2024
Nanjing Drum Tower Hospital
2011-2024
Nanjing University of Chinese Medicine
2011-2024
Affiliated Hospital of Shaanxi University of Chinese Medicine
2024
Shaanxi Provincial People's Hospital
2024
Shaanxi Provincial People's Hospital
2020-2024
Diabetic Retinopathy (DR) stage classification has been regarded as a critical step for evaluation and management of diabetes retinopathy. Because damages the retina blood vessels caused by high glucose level, different extent microstructures, such micro-anuerysms, hard exudates, neovascularization, could occupy area. Deep learning based Convolutional Neural Network (CNN) recently proved promising approach in biomedical image analysis. In this work, representative images have aggregated into...
We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and stimulation VEGF ACTH; latter is largely responsible for maintaining fine vascular network surrounds highly remodeling bone. suggest examining efficacy ACTH in preventing human osteonecrosis, a devastating complication glucocorticoid therapy.
Primary vitreoretinal lymphoma (PVRL) or primary intraocular lymphoma, a subtype of central nervous system often masquerades as uveitis. The diagnosis PVRL requires identification cells inside the eye, which is challenging due to frequent necrosis and admixing with reactive lymphocytes. Therefore, detection immunoglobulin heavy chain (IgH) T-cell receptor (TCR) gene rearrangements provide molecular B- respectively. We retrospectively evaluated 208 cases clinical masquerade syndrome from 1998...
Many blood-feeding arthropods are known vectors of viruses that a source unprecedented global health concern. Mosquitoes an integral part these arthropod vectors. Advancements in next-generation sequencing and bioinformatics has expanded our knowledge on the richness harbored by arthropods. In present study, we applied metagenomic approach to determine intercontinental virome diversity Culex quinquefasciatus tritaeniorhynchus Kwale, Kenya provinces Hubei Yunnan China. Our results showed...
Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there no histopathologic documentation. We report clinical history and confirmation that EBV can ARN.Clinical course histopathology patient diagnosed with ARN infection confirmed molecular pathology.Epstein-Barr recognized intraocular inflammation possible ARN. However, tissue demonstration in not previously...
Introduction Slow transit constipation (STC) is a type of functional constipation. The detailed mechanism STC, for which there currently no effective treatment, unknown as yet. Tongbian decoction (TBD), traditional Chinese medicinal formula, commonly used to treat STC in clinical settings. However, the potential impact TBD on management via modulation gut microbiota remains unclear. Methods Pseudo-germ-free rats were constructed after 6 days treatment with bacitracin, neomycin, and...
AMD (age-related macular degeneration) is a neurodegenerative disease causing irreversible central blindness in the elderly. Apoptosis and inflammation play important roles pathogenesis. PEDF (pigment epithelium-derived factor) potent neurotrophic anti-inflammatory glycoprotein that protects retinal neurons photoreceptors against cell death caused by pathological insults. We studied effects of on focal lesions DKO rd8 ( Ccl2 −/− /Cx3cr1 C57BL/6N [ Crb1 ]) mice, model for progressive, rd...
Age-related macular degeneration (AMD) is a common yet complex retinal that causes irreversible central blindness in the elderly. Pathology widely believed to follow loss of pigment epithelium (RPE) and photoreceptor degeneration. Here we report aberrant expression interleukin-17A (IL17A) receptor IL17RC macula AMD patients. In vitro, IL17A induces RPE cell death characterized by accumulation cytoplasmic lipids autophagosomes with subsequent activation pro-apoptotic Caspase-3 Caspase-9. This...
N6-methyladenosine (m6A), the most abundant internal RNA modification in humans, regulates aspects of processing. Prostate cancer is characterized by widespread transcriptomic dysregulation; therefore, we m6A landscape 162 localized prostate tumors with matched DNA, and protein profiling. abundance varied dramatically across tumors, global patterns emerging via complex germline–somatic cooperative regulation. Individual germline polymorphisms regulated abundance, cooperating somatic mutation...
Abstract Background Inflammatory responses are detected in the retina of patients with age-related macular degeneration and Ccl2 -/- /Cx3cr1 mice on rd8 background,( mice) a model that develops progressive degeneration-like retinal lesions including focal photoreceptor degeneration, abnormal pigment epithelium A2E accumulation. Tumor necrosis factor-inducible gene 6 protein is an anti-inflammatory has been shown to improve myocardial infarction outcome chemically injured cornea by...
Patients with castration-resistant prostate cancer (CRPC) can be treated abiraterone, a potent inhibitor of androgen synthesis, or enzalutamide, second-generation receptor (AR) antagonist, both targeting AR signaling. However, most patients relapse after several months therapy and majority relapsed CRPC tumors express the target gene prostate-specific antigen (PSA), suggesting that signaling is reactivated targeted again to inhibit tumors. Novel small molecules capable inhibiting function...
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The novel tumor targeted nano-drug C-PC/CMC-CD59sp nanoparticles were constructed with carbocymethyl chitosan (CMC), C-phycocyanin (C-PC) and CD59 specific ligand peptide (CD59sp). anti-tumor drug mechanism of the NPs was further explored in cervical cancer cells (HeLa SiHa) vitro vivo. We found that could inhibit proliferation induce G0/G1 cell cycle arrest HeLa SiHa cells, reduced a dose-dependent manner. regulated via up-regulating expression p21, then down-regulating expressions Cyclin...
Atopic dermatitis (AD) is a common and recurrent skin disease. The first onset of AD in adults known as adult-onset atopic (AOAD). Gut microbiota closely associated with AD, the "gut-skin" axis considered novel target for prevention AD. However, only few studies have analyzed AOAD, particularly that compared differences intestinal flora between AOAD persistent patients.To investigate main specificities patients, comparing patients.A comprehensive taxonomic functional analysis gut 10 healthy,...
Coronavirus disease 2019 (COVID-19) systemic symptoms and sequelae have been studied extensively, but less is known about the characterization, duration, long-term of ocular associated with COVID-19 infection. The purpose this study was to analyze frequency, spectrum, duration in participants infection treated inpatient outpatient settings.A retrospective electronic survey distributed NIH employees public who reported testing positive for SARS-CoV-2. anonymous collected information on...
Paraneoplastic retinopathy is caused by the cross-reaction of neoplasm-directed autoantibodies against retinal antigens and results in damage. vitelliform retinopathy, a presumed paraneoplastic with features atypical melanoma-associated has recently been reported patients metastatic melanoma. Ocular ultrastructure its autoantibody localization are still indefinable. This first report anti-transient receptor potential M1 antibody directly human bipolar dendritic tips melanoma patient...