A5100433269- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Retinal Diseases and Treatments
- Gestational Diabetes Research and Management
- Neurological Disorders and Treatments
- Prenatal Screening and Diagnostics
- Pregnancy-related medical research
- Glaucoma and retinal disorders
- Maternal and Perinatal Health Interventions
- Reproductive tract infections research
- Facial Nerve Paralysis Treatment and Research
- Ectopic Pregnancy Diagnosis and Management
- Chemokine receptors and signaling
- Biomedical Research and Pathophysiology
- Genetic and Kidney Cyst Diseases
- Transplantation: Methods and Outcomes
- Statistical Methods in Epidemiology
- bioluminescence and chemiluminescence research
- Developmental Biology and Gene Regulation
- Grief, Bereavement, and Mental Health
- Immune cells in cancer
- Chemotherapy-induced cardiotoxicity and mitigation
- Effects and risks of endocrine disrupting chemicals
National Institutes of Health
2004-2018
National Eye Institute
2010-2017
National Institute of Neurological Disorders and Stroke
2010-2016
Synaptic Research (United States)
2013
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2007-2010
University of California, Los Angeles
2007
Aarhus University
2007
Weatherford College
2007
National Heart Lung and Blood Institute
1999-2000
Washington Hospital
1999
Background. We sought to assess the relationship between bacterial vaginosis (BV) assessed by Gram stain and incident trichomonal, gonococcal, and/or chlamydial genital infection.
Microglia, the principal resident immune cell of CNS, exert significant influence on neurons during development and in pathological situations. However, if how microglia contribute to normal neuronal function mature uninjured CNS is not well understood. We used model adult mouse retina, a part amenable structural functional analysis, investigate constitutive role by depleting from retina sustained manner using genetic methods. discovered that are acutely required for maintenance retinal...
Chemokine signaling via CX3CL1-CX3CR1 helps regulate homeostasis in the population of microglia adult mouse retina.
Previous studies suggest that infection may play a role in restenosis and atherogenesis; cytomegalovirus (CMV) is one of the implicated pathogens. To determine potential causal CMV these disease processes, we assessed whether increases neointimal response to injury rat carotid artery.Carotid was performed on 60 rats; immediately thereafter, 30 rats were infected with CMV, other mock-infected. Six weeks later, euthanized, salivary glands, spleen, arteries harvested. associated significant...
Neuronal microcircuits, small, localized signaling motifs involving two or more neurons, underlie signal processing and computation in the brain. Compartmentalized within a neuron may enable it to participate multiple, independent microcircuits. Each A17 amacrine cell mammalian retina contains its dendrites hundreds of synaptic feedback microcircuits that operate independently modulate feedforward inner retina. these comprises small (<1 μm) varicosity typically receives one excitatory...
Abstract Background Inflammatory responses are detected in the retina of patients with age-related macular degeneration and Ccl2 -/- /Cx3cr1 mice on rd8 background,( mice) a model that develops progressive degeneration-like retinal lesions including focal photoreceptor degeneration, abnormal pigment epithelium A2E accumulation. Tumor necrosis factor-inducible gene 6 protein is an anti-inflammatory has been shown to improve myocardial infarction outcome chemically injured cornea by...
The glaucoma-associated gene, myocilin, is expressed in ocular and non-ocular tissues including the peripheral nervous system, but its functions these remain poorly understood. We demonstrate that sciatic nerve, myocilin Schwann cells with high concentrations at nodes of Ranvier. There, interacts gliomedin, neurofascin, NrCAM, which are essential for node formation function. Treatment isolated dorsal root ganglion cultures stimulates clustering nodal proteins neurofascin sodium channel...
Photoreceptor ribbon synapse releases glutamate to postsynaptic targets. The synaptic may play multiple roles in development, vesicle recycling, and transmission. Age-related macular degeneration (AMD) patients appear have fewer or no detectable ribbons as well abnormal swelling the photoreceptor terminals macula. However, reports on changes of synapses AMD are scarce type quantity affected early is still unclear. Here, we employed anatomical techniques investigate these questions...
Background: Placental trophoblast shedding into maternal circulation has been hypothesized as a potential cause of preeclampsia. Because pregnancies with trisomy 21 fetus also have high levels fetal cells and cell-free DNA in circulation, we examined whether higher risk preeclampsia than euploid pregnancies. Methods: We used 2 population-based databases. identified 7763 singleton 21-affected 15,293 matched gestations from the U.S. Natality files for period 1995–1999. The second database...
Retinal ganglion cells (RGCs) receive excitatory glutamatergic input from bipolar cells. Synaptic excitation of RGCs is mediated postsynaptically by NMDA receptors (NMDARs) and AMPA (AMPARs). Physiological data have indicated that glutamate at are expressed not only in postsynaptic but also perisynaptic or extrasynaptic membrane compartments. However, precise anatomical locations for RGC synapses been determined. Although a high-resolution quantitative analysis central widely employed, this...
In the rapidly evolving landscape of smartphone technology and micro-interaction design, our research aims to extend applicability Fitts' Law better understand model dynamics finger stroke gestures on commercial applications. Traditional interpretations Law, which primarily rely distance (D) target width (W) quantify task difficulty (ID) in gesture input, may not be sufficient capturing complexities inherent touchscreen interactions with To address this gap, we propose an adaptation that...
Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute Child Health Human Development, Institutes Health, Besthesda, Maryland Financial Disclosure: The authors did not report any potential conflicts interest.
First-trimester surgical abortion is established as a safe procedure, but relatively little known about whether and how so-called medical abortion—achieved using one or more medications—affects subsequent pregnancies. Current regimens for include misoprostol alone, methotrexate followed by and, far the commonest method, mifepristone misoprostol. The investigators analyzed nationwide Danish cohort to learn carries an increased risk of ectopic pregnancy, spontaneous abortion, preterm birth...