A5056453500- Vaccine Coverage and Hesitancy
- Hate Speech and Cyberbullying Detection
- Electronic Health Records Systems
- Misinformation and Its Impacts
- History and Theory of Mathematics
- Mobile Health and mHealth Applications
- Interprofessional Education and Collaboration
- Mathematics Education and Teaching Techniques
- Data-Driven Disease Surveillance
- Cytokine Signaling Pathways and Interactions
- Public Health Policies and Education
- Colorectal Cancer Treatments and Studies
- Ethics in Clinical Research
- Healthcare Systems and Technology
- HER2/EGFR in Cancer Research
- Teacher Professional Development and Motivation
- Education and Critical Thinking Development
- Computational and Text Analysis Methods
- Ubiquitin and proteasome pathways
- Nursing Diagnosis and Documentation
- Teacher Education and Leadership Studies
- Patient Safety and Medication Errors
- Creative Drama in Education
- Artificial Intelligence in Healthcare
- Retinal and Macular Surgery
The University of Texas at Arlington
2021-2024
Robert Gordon University
2023
University of Colorado Anschutz Medical Campus
2022
University of Southern Indiana
2012-2018
University of Pittsburgh
2011-2015
Kyushu University
2015
University of Cagliari
2015
University of Virginia
2015
Health Resources and Services Administration
2015
Wilson College
2014
Abstract Although diacylglycerol kinase α (DGKα) has been linked to several signaling pathways related cancer cell biology, it neglected as a target for therapy. The attenuation of DGKα activity via DGKα-targeting siRNA and small-molecule inhibitors R59022 R59949 induced caspase-mediated apoptosis in glioblastoma cells other cancers, but lacked toxicity noncancerous cells. We determined that mTOR hypoxia-inducible factor-1α (HIF-1α) are key targets inhibition, addition its regulation...
BACKGROUND. HIV/AIDS mortality rates in the United States are declining; pediatric HIV has become a chronic disease, with quality of life (QoL) outcomes assuming greater importance. OBJECTIVES. To compare QoL among HIV-infected and uninfected children to assess impact different antiretroviral regimens on children. METHODS. Perinatally exposed, (N = 1847) 712) adolescents were studied. Among infected children, 1283 available for regimen analysis. domain scores assessed subjects 6 months 4...
<sec> <title>BACKGROUND</title> Prior studies have identified key factors contributing to COVID-19 vaccine hesitancy, including concerns over safety, potential side effects, and mistrust in the healthcare system. According World Health Organization, hesitancy is among top ten threats global public health. Previous research suggests that a significant barrier within Hispanic population, particularly Texas. </sec> <title>OBJECTIVE</title> This longitudinal study examines relationship between...
Nuclear factor κB (NF-κB) is a transcription important for regulating innate and adaptive immunity, cellular proliferation, apoptosis, senescence. Dysregulation of NF-κB its upstream regulator IκB kinase (IKK) contributes to the pathogenesis multiple inflammatory degenerative diseases as well cancer. An 11-amino acid peptide containing essential modulator (NEMO)-binding domain (NBD) derived from C-terminus β subunit IKK, functions highly selective inhibitor IKK complex by disrupting...
Hepatocellular carcinoma (HCC), the third most common cause of cancer-related deaths worldwide, lacks effective medical therapy. Large subsets HCC demonstrate Wnt/β-catenin activation, making this an attractive therapeutic target. We report strategy and characterization a novel small-molecule inhibitor, ICG-001, known to affect Wnt signaling by disrupting β-catenin-CREB binding protein interactions. queried ZINC online database for structural similarity ICG-001 identified PMED-1 as lead...
Patients with castration-resistant prostate cancer (CRPC) can be treated abiraterone, a potent inhibitor of androgen synthesis, or enzalutamide, second-generation receptor (AR) antagonist, both targeting AR signaling. However, most patients relapse after several months therapy and majority relapsed CRPC tumors express the target gene prostate-specific antigen (PSA), suggesting that signaling is reactivated targeted again to inhibit tumors. Novel small molecules capable inhibiting function...
Vaccination represents a major public health intervention intended to protect against COVID-19 infections and hospitalizations. However, vaccine hesitancy due misinformation/disinformation, especially among ethnic minority groups, negatively impacts the effectiveness of such an intervention. The aim this study is provide understanding how information gleaned from social media can be used improve attitudes toward vaccination decrease hesitancy. This work focused on Spanish-language posts,...
Signal transducer and activator of transcription factor 3 (STAT3) is hyperactivated in head neck squamous cell carcinomas (HNSCC). Cumulative evidence indicates that IL-6 production by HNSCC cells and/or stromal the tumor microenvironment activates STAT3 contributes to progression drug resistance. A library 94,491 compounds from Molecular Library Screening Center Network (MLSCN) was screened for ability inhibit interleukin-6 (IL-6)-induced pSTAT3 activation. For contractual reasons, primary...
Ineffective collaboration and communication contribute to fragmented patient care potentially increase adverse events, clinical errors, poor outcomes. Improving is essential; however, interprofessional education (IPE) supporting this cause not a common practice. Most often healthcare profession students are educated in profession-centered silos limiting opportunities develop effective practices. Students from nursing, health informatics, radiologic technology collaboratively populated an...
Toxoplasma gondii is an obligate intracellular parasite that can cause disease in the developing fetus and immunocompromised humans. Infections last for life of individual, to date there are no drugs eliminate chronic cyst stages characteristic this parasite. In effort identify new chemical scaffolds could form basis therapeutics, we carried out a chemoinformatic screen compounds had potential interact with members superfamily parasite-secreted kinases assayed them growth inhibition vitro....
The acute effect of the potent cyclin-dependent kinase (cdk) inhibitor (R)-roscovitine on Ca2+ channels inspired development structural analogues as a potential treatment for motor nerve terminal dysfunction. On basis versatile chlorinated purine scaffold, we have synthesized ca. 20 derivatives and characterized their N-type channel agonist action. Agents that showed strong effects were also in panel off-target effects. Among several novel compounds with diminished cdk activity, identified...
Protein kinase D (PKD) is a novel family of serine/threonine kinases regulated by diacylglycerol, which involved in multiple cellular processes and various pathological conditions. The limited number cell-active, selective inhibitors has historically restricted biochemical pharmacological studies PKD. We now markedly expand the PKD1 inhibitory chemotype inventory with eleven additional small molecule derived from our high throughput screening campaigns. vitro IC(50)s for these compounds...
Vaccine hesitancy represents a barrier to public health efforts aiming mitigate the pandemic by performing global interventions. One of reasons behind vaccine is mistrust towards system that partially originated due misinformation shared over internet. This study examined association between credibility sources regarding COVID-19 posted on social media and vaccination rate at state level in United States. Study findings suggest sharing more Facebook posts with links low-credibility about...
Abortion remains one of the most controversial topics, especially after overturning Roe v. Wade ruling in United States. Previous literature showed that illegality abortion could have serious consequences, as women might seek unsafe pregnancy terminations leading to increased maternal mortality rates and negative effects on their reproductive health. Therefore, stances abortion-related Facebook posts were analyzed at state level States from May 4 until June 30, 2022, right Supreme Court’s...
Prior works have shown connections between online toxicity attacks, such as harassment, cyberbullying, and hate speech, the subsequent increase in offline violence, well negative psychological effects on victims. These correlations are primarily identified through user studies conducted via virtual environments, simulations, questionnaires. However, no work has investigated how, practice authentically, people react to both emotionally, showing anger, anxiety, sadness, behaviorally terms of...
Author Affiliations: Assistant Professor, Nursing (Dr Schaar), Health Informatics Mustata Wilson), College of and Professions, University Southern Indiana, Evansville. Dr Wilson contributed equally to this work. The authors declare no conflicts interest. Correspondence: Schaar or Wilson, 8600 Blvd, Evansville, IN 47712 ([email protected]; [email protected]). Published ahead print: August 22, 2014
Abstract Background The dramatic increase in complexity and volume of health data has challenged traditional systems to deliver useful information their users. novel coronavirus disease 2019 (COVID-19) pandemic further exacerbated this problem demonstrated the critical need for 21st century approach. This approach needs ingest relevant, diverse sources, analyze them, generate appropriate intelligence products that enable users take more effective efficient actions specific challenges....
As the number of older adults is growing rapidly in U.S., need for personalized, innovative, and sustainable Information Communication Technologies (ICTs) solutions critical to support individuals' social, emotional, physical health. Such technology can significantly help adults' ability live independently their homes despite challenges aging process may present, referred as or staging place. In this study, we explored ways integrate ICTs into Agile Dwelling Units (AgDUs) through affordable,...
This study describes the eHealth4all@eu course development pipeline that builds upon TIGER educational recommendations and allows a systematic grounded on scientific field requirements of competencies, case/problem-based pedagogical approach finally results in syllabus content. The is exemplified by Learning Healthcare Action: Clinical Data Analytics.
The aims of the study were to examine association between social media sentiments surrounding COVID-19 vaccination and effects on rates in United States (US), as well other contributing factors vaccine hesitancy.The dataset used this consists vaccine-related English tweets collected real-time from January 4 - May 11, 2021, posted within US, health literacy (HL), vulnerability index (SVI), at state level.The findings presented demonstrate a significant correlation rate US. results also...