A5112165210- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Kawasaki Disease and Coronary Complications
- COVID-19 Impact on Reproduction
- Pneumocystis jirovecii pneumonia detection and treatment
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- HIV-related health complications and treatments
- Vaccine Coverage and Hesitancy
- Liver Diseases and Immunity
- Appendicitis Diagnosis and Management
- Global Cancer Incidence and Screening
- Tuberculosis Research and Epidemiology
- Parvovirus B19 Infection Studies
- HIV, Drug Use, Sexual Risk
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Streptococcal Infections and Treatments
- Animal Virus Infections Studies
- Diagnosis and treatment of tuberculosis
- Restraint-Related Deaths
Rutgers, The State University of New Jersey
2011-2025
Johnson University
2009-2025
Rutgers Sexual and Reproductive Health and Rights
2014-2024
Jawaharlal Nehru Medical College
2024
The Bristol-Myers Squibb Children's Hospital
2021
Defence Research and Development Organisation
2020
Robert Wood Johnson University Hospital
2018
Brunswick (United States)
2014
Children's Hospital of The King's Daughters
2013
Pediatrics and Genetics
1993
Multisystem inflammatory syndrome in children (MIS-C) is associated with recent or current SARS-CoV-2 infection. Information on MIS-C incidence limited.To estimate population-based per 1 000 person-months and to infections persons younger than 21 years.This cohort study used enhanced surveillance data identify during April June 2020, 7 jurisdictions reporting both the Centers for Disease Control Prevention national Overcoming COVID-19, a multicenter study. Denominators estimates were derived...
Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed characterize pediatric PASC enable studies underlying mechanisms that will guide future treatment.
We describe the temporal pattern of COVID-19 admissions to a tertiary care children's hospital in central New Jersey during SARS-CoV-2 surge, covering time period from March 29 July 26, 2020.Medical charts were reviewed for date admission, past medical history, and demographic variables, presenting signs symptoms, admitting laboratory values, diagnostic imaging, diagnosis, treatment modalities, outcomes including length stay disease severity.Patients with symptomatic infection tended present...
We describe a child who apparently acquired human immunodeficiency virus type 1 (HIV-1) infection in the home setting. The suspected source of was with syndrome had received zidovudine and whose contained mutation associated vitro resistance. children were born to different HIV-1-infected mothers, but they lived same between ages two five years. Child infected perinatally; 2 not repeatedly found be seronegative. examined because acute lymphadenopathy seroconverted HIV-1 positivity. proviral...
BACKGROUND. HIV/AIDS mortality rates in the United States are declining; pediatric HIV has become a chronic disease, with quality of life (QoL) outcomes assuming greater importance. OBJECTIVES. To compare QoL among HIV-infected and uninfected children to assess impact different antiretroviral regimens on children. METHODS. Perinatally exposed, (N = 1847) 712) adolescents were studied. Among infected children, 1283 available for regimen analysis. domain scores assessed subjects 6 months 4...
Importance The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae SARS-CoV-2 [PASC] or “Long COVID”) in children young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, potential treatment targets adults. Observations We describe protocol for Pediatric Observational Cohort Study NIH’s RE searching COV ID E nhance R ecovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study caregiver-child...
The White Blood Cell (WBC) count is one of the key parameters signaling health immune system. Abnormal WBC counts often signal a systemic insult to body such as an underlying infection or adverse side effect medication. Typically, blood collected sent central lab for testing, and results come back within hours, which inconvenient may delay time-sensitive diagnosis treatment. Here, we present CytoTracker, fully electronic, microfluidic based instant analyzer with potential be used at...
Abstract Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, mucocutaneous, and/or cardiovascular injury occurring weeks after severe acute respiratory coronavirus 2 (SARS-CoV-2) exposure. To investigate functions, we stimulated ex vivo peripheral blood cells from MIS-C patients with agonists of Toll-like receptors (TLR), key response initiators. We found severely dampened cytokine and elevated gene...
Abstract Background We studied risk factors, antibodies, and symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a diverse, ambulatory population. Methods A prospective cohort (n = 831) previously undiagnosed with SARS-CoV-2 underwent serial testing (SARS-CoV-2 polymerase chain reaction, immunoglobulin G [IgG]) for 6 months. Results Ninety-three participants (11.2%) tested SARS-CoV-2-positive: 14 (15.1%) asymptomatic, 24 (25.8%) severely symptomatic....
Data for 38 children perinatally exposed to human immunodeficiency virus (HIV) were evaluated determine the impact of cytomegalovirus (CMV) infection on course acquired HIV infection. Thirteen belonged Po (indeterminate) group, one P1 (asymptomatic) and 24 P2 (symptomatic) per classification Centers Disease Control. Of in 10 died. The mean follow-up time was 22.8 months who died 16.3 13 group. Serial cultures urine performed all patients. CMV isolated from seven four 14 survived (P < .05)....
Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, mucocutaneous, and/or cardiovascular injury occurring weeks after SARS-CoV-2 exposure. To investigate functions MIS-C, we stimulated
Protection from severe disease and hospitalization by SARS-CoV-2 vaccination has been amply demonstrated real-world data. However, the rapidly evolving pandemic raises new concerns. One pertains efficacy of adenoviral vector-based vaccines, particularly single-dose Ad26.COV2.S, relative to mRNA vaccines.
The duration of treatment and appropriate guidelines for antibiotic prophylaxis children with poststreptococcal reactive arthritis (PSRA) have not been determined. authors performed a retrospective chart review 40 PSRA examined their clinical features at initial evaluation 6, 12, 24 months. At baseline, 18% (n = 7) had finding noted on the echocardiogram. Although most patients developed cardiac findings early in course disease, 2 normal baseline echocardiogram may after 12 months follow-up....
This study aims to quantify clinical and economic burden of rotavirus (RV) infection pre- post-vaccine introduction in commercially insured Medicaid populations. Beneficiaries with continuous enrollment for ≥6 months while <5 years age were identified separately commercial (2000–2010) (2002–2009) claims databases. Commercial databases included 3 998 708 1 034 440 eligible children, respectively, observed from start date(s) end eligibility or 5-years-old. Rates RV-coded diarrhea-coded...
Abstract Both the human immunodeficiency virus (HIV) and environmental stress have been independently associated with decreased cognitive functioning in children. Given that they are also known to a strong relationship each other, present study sought test hypothesis children conditions of high risk would be at greater for complications related immunosuppression. A retrospective review was conducted examine records 141 treated large pediatric AIDS clinic from 1993 2000. CD4+ lymphocyte...
The syncytium-inducing (SI) capability of HIV-1 isolates from 48 HIV-infected children was determined in order to examine the association SI phenotype with an AIDS diagnosis and/or other clinical parameters children. In a retrospective cross-sectional analysis, phenotypic data were linked and immunologic each patient. Multiple longitudinal samples analyzed 14 patients. Children viruses older than nonsyncytium-inducing (NSI) strains. Twelve 13 less 2 years old carried NSI viruses, seven 12...
To report on the clinical, laboratory, and radiological findings of adolescents who presented during SARS-CoV-2 surge with symptoms Coronavirus disease 2019 (COVID-19), did not test positive for infection, were diagnosed E-cigarette vaping product use associated lung injury (EVALI).A retrospective review 12 cases EVALI admitted to Bristol Meyers Squibb Children's Hospital between February 2020 June was conducted.The ages patients ranged from 14 19 years. There six males females. Three had a...
Studies on basal and pentagastrin-stimulated gastric secretion were carried out in 20 patients with cirrhosis, non-cirrhotic portal fibrosis (NCPF) control subjects. There was no significant difference the volume acid output between three groups. However, maximal significantly lower cirrhosis NCPF compared group. correlation degree of hepatocellular dysfunction cirrhosis. Moreover, hyposection as marked those although former did not suffer from any hepatic decompensation. It is concluded...
Objectives: Colorectal cancer (CRC) is the third most common among Americans of South Asian (SA) descent and a significant public health concern in SA communities. Rates screening compliance foreign-born SAs are very low. The goal this study was to report on development, acceptability, preliminary impact culturally-targeted 1:1 intervention delivered English, Hindi, Urdu, called Desi-Sehat.Design: Ninety-three between ages 50 75 were recruited using community-based organization methods....