A5032681043- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- HIV/AIDS Research and Interventions
- NF-κB Signaling Pathways
- Kawasaki Disease and Coronary Complications
- HIV Research and Treatment
- RNA Research and Splicing
- Adipokines, Inflammation, and Metabolic Diseases
- Lymphoma Diagnosis and Treatment
- HIV-related health complications and treatments
- Trypanosoma species research and implications
- Biomarkers in Disease Mechanisms
- Melanoma and MAPK Pathways
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Cardiomyopathy and Myosin Studies
- Coenzyme Q10 studies and effects
- HIV/AIDS drug development and treatment
- Macrophage Migration Inhibitory Factor
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immunotherapy and Immune Responses
Rutgers, The State University of New Jersey
2015-2024
Rutgers Sexual and Reproductive Health and Rights
2024
Rutgers Health
2019
Rutgers New Jersey Medical School
2019
Tuberculosis (TB), caused by
Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, mucocutaneous, and/or cardiovascular injury occurring weeks after SARS-CoV-2 exposure. To investigate functions MIS-C, we stimulated
Chagas disease is caused by Trypanosoma cruzi which endemic in Latin America. T. infection results a latent with approximately third of latently infected patients developing chronic cardiomyopathy (CCM). CCM common cause regions and has poor prognosis compared to other cardiomyopathies. The factors responsible for the transition from asymptomatic indeterminate stage are poorly understood. Our previous studies demonstrated that lipid metabolism diet important determinants progression. In...
Abstract Multisystem inflammatory syndrome in children (MIS-C) is a rare, severe complication of COVID-19 characterized by multi-lineage immune activation and multi-organ system involvement. While baseline immunophenotypes have been characterized, innate cell functionality genetic risk factors remain poorly understood. To address these knowledge gaps, we assessed responses with MIS-C (n = 33) relative to healthy controls 5). We found that Toll like receptor (TLR) signaling severely dampened...
CD40 ligand (CD40L) mRNA stability is dependent on an activation-induced pathway that mediated by the binding complexes containing multifunctional RNA-binding protein, polypyrimidine tract-binding protein 1 (PTBP1) to a 3' untranslated region of transcript. To understand relationship between regulated CD40L and requirement for variegated expression during T-dependent response, we engineered mouse lacking element (CD40LΔ5) asked how this mutation altered multiple aspects humoral immunity. We...
Abstract We have described a posttranscriptional pathway of induced mRNA stability that occurs at late times T cell activation and is engaged by the binding polypyrimidine tract-binding protein (PTBP1) complex to 3′UTR CD40L transcript. explored in vivo role this generating mouse bearing deletion element (termed CD40LΔ5) found Tfh cells harboring defect expressed approximately 60% WT CD40L. Importantly, decrease corresponded poorly elaborated germinal center (GC) response which included...
ABSTRACT Our previous work found that the RNA binding protein polypyrimidine tract-binding (PTBP1) is critical for regulating multiple events in T cell activation including changes proliferation, and expression of markers cytokines. These corresponded to regulation ERK1/2 NF-κB pathways as well through steady-state levels. Because proliferation driving activation, it was unclear whether PTBP1 required optimal per se or were secondary a requirement initiating/sustaining proliferation. To...
Abstract Increased levels of CD40L have been observed on CD4 T cells patients with systemic lupus erythematosus (SLE) and in several murine models lupus-like disease. Notably, elevated/prolonged expression corresponds to the expansion survival autoreactive B cells. However, targeting as a potential therapeutic has challenging due development off-target events. We developed unique mouse model termed CD40LΔ5 (Δ5) which lacks stability element 3’ UTR message upon immunization, shows decreased...