A5007442463- Herpesvirus Infections and Treatments
- Poxvirus research and outbreaks
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- Bartonella species infections research
- HIV/AIDS Research and Interventions
- Child Nutrition and Water Access
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- Hemoglobinopathies and Related Disorders
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Iron Metabolism and Disorders
- Global Maternal and Child Health
- HIV-related health complications and treatments
- SARS-CoV-2 and COVID-19 Research
- Vector-borne infectious diseases
- Virology and Viral Diseases
- HIV/AIDS drug development and treatment
- Pneumonia and Respiratory Infections
- Food Allergy and Anaphylaxis Research
- Hepatitis Viruses Studies and Epidemiology
Columbia University Irving Medical Center
2007-2024
Columbia University
2013-2022
Duke University
2020
New York Proton Center
1998-2017
New York University
1984-2016
Pediatrics and Genetics
2016
New York Hospital Queens
2015
Morgan Stanley Children's Hospital
2012-2014
Royal College of Physicians
1998-2013
Scripps Clinic
2013
There are only limited data on human immunodeficiency virus type 1 (HIV-1) RNA in perinatally infected infants. Understanding the dynamics of HIV-1 infection and its relation to disease progression may help identify opportunities for effective antiviral treatment
The Oka strain of live attenuated varicella vaccine is immunogenic and highly protective, but there has been concern about the risk zoster after immunization.We examined incidence zoster, factors for it, measures immune response in children with leukemia who received appropriate controls.After a mean follow-up 4.1 years, was documented 13 548 vaccinated (2.4 percent). In subgroup 96 matched prospectively had natural infections, were 4 cases among 15 controls, crude rates 0.80 2.46 per 100...
The nucleotide changes that result in two restriction endonuclease polymorphisms differentiate wild-type varicella-zoster virus (VZV) from the vaccine strain were determined. Oligonucleotide primers flank these sites used to amplify intervening sequences with polymerase chain reaction identify VZV DNA clinical isolates. Restriction enzyme digestion of amplification products distinguished and genomes one another. This study confirms feasibility amplifying so they may be detected specimens...
Journal Article Immunization of Healthy Adults with Live Attenuated Varicella Vaccine Get access Anne A. Gershon, Gershon Please address requests for reprints to Dr. Department Pediatrics, Columbia University, College Physicians & Surgeons, 650 West 168th Street, New York, York 10032. Search other works by this author on: Oxford Academic PubMed Google Scholar Sharon P. Steinberg, Steinberg Philip LaRussa, LaRussa Angelo Ferrara, Ferrara Margaret Hammerschlag, Hammerschlag Lawrence Gelb, Gelb...
Background. Because of ongoing outbreaks varicella, a second dose varicella vaccine was added to the routine immunization schedule for children in June 2006 by Centers Disease Control and Prevention. Methods. We assessed effectiveness 2 doses case-control study identifying ≥4 years age with confirmed polymerase chain reaction assay up controls matched pediatric practice. Effectiveness calculated using exact conditional logistic regression. Results. From July January 2010, 71 case subjects...
Universal immunization of young children with 1 dose varicella vaccine was recommended in the United States 1995, and it has significantly decreased incidence chickenpox. Outbreaks varicella, however, are reported among vaccinated children. Although effectiveness usually been 85%, rates as low 44% have observed. Whether this is from primary or secondary failure-or both-is unclear. We tested serum samples 148 healthy immunized against New York, Tennessee, California to determine their...
This article describes a prospective longitudinal study of varicella-zoster virus (VZV) infections in human immunodeficiency (HIV)-infected children, designed to determine their natural history VZV infection and possible effects on the progression HIV infection. Varicella was usually not serious acute problem, it did seem precede clinical deterioration. The rate zoster high: 70% children with low levels CD4/ lymphocytes at time development varicella. It is predicted that immunization live...
The epidemiology and clinical features of human coronaviruses (HCoVs) in children are not fully characterized.
BACKGROUND. HIV/AIDS mortality rates in the United States are declining; pediatric HIV has become a chronic disease, with quality of life (QoL) outcomes assuming greater importance. OBJECTIVES. To compare QoL among HIV-infected and uninfected children to assess impact different antiretroviral regimens on children. METHODS. Perinatally exposed, (N = 1847) 712) adolescents were studied. Among infected children, 1283 available for regimen analysis. domain scores assessed subjects 6 months 4...
Although varicella vaccine is given to clinically stable human immunodeficiency virus (HIV)-infected children, its effectiveness unknown. We assessed by reviewing the medical records of closely monitored HIV-infected including those receiving highly active antiretroviral therapy (HAART) between 1989 and 2007. Varicella immunization development or herpes zoster were noted. Effectiveness was calculated subtracting from 1 rate ratios for incidence rates in vaccinated versus unvaccinated...
Live attenuated varicella vaccine is recommended for healthy individuals who are susceptible to varicella. Although the safe, effective, and used worldwide, serious adverse events have been reported, mainly in immunocompromised patients subsequently recovered. Here, we describe fatality of an patient received vaccine. His medical history provides a cautionary lens through which view decision when vaccination appropriate. A middle-aged man with non-Hodgkin lymphoma chemotherapy stem cell...
Objectives The main objective of this study was to assess practices antibiotic prescription at registered drug shops with a focus on upper respiratory tract infections among children in order provide data for policy discussions aimed improving quality care and patient safety the private health sector Uganda. Methods A survey conducted within 57 parishes from August October 2014 Mukono District, Data captured following variables: shop characteristics, training staff management pneumonia,...
An observational study found an increased risk of febrile seizure on the day or 1 after vaccination (days 0-1) with trivalent inactivated influenza vaccine (TIV) in 2010-2011 season; was highest simultaneous TIV and 13-valent pneumococcal (PCV13) children who were 6 to 23 months old. Text messaging is a novel method for surveillance adverse events immunization that has not been used hypothesis-driven safety research.To prospectively evaluate whether receiving PCV13 simultaneously had higher...
Varicella vaccine in immunocompromised children was clinically evaluated 575 US and Canadian with leukemia remission by the Vaccine Collaborative Study. Most had chemotherapy stopped 1 week before after immunization. Steroids were for 3 weeks (1 to 2 vaccination). safe, immunogenic, effective leukemic at risk serious disease or death from chickenpox. The major side effect mild rash 50% approximately month About 40% of who developed treated acyclovir. efficacy judged degree protection a...
The varicella vaccine was approved in 1995 for use healthy varicella-susceptible children and adults. Long-term immunity 461 adults who were enrolled trials 1979–1999 studied. Forty vaccinees (9%), including 19 (21%) of 89 with household exposure (HHE) to chickenpox, developed breakthrough chickenpox 8 weeks 11.8 years (mean, 3.3 years) after vaccination. median number skin lesions among the 36 untreated 20 (range, 1–240 lesions), essentially same time since Breakthrough mild, even did not...
The Food and Drug Administration licensed a live-virus varicella vaccine (Varivax; Merck & Co Inc, West Point, PA) in March 1995. Prelicensure adverse events were minimal; however, since licensure increased use, rare previously undetected risks have arisen. Presented here is the clinical course of undiagnosed, human immunodeficiency virus-infected boy who developed dissemination strain zoster after immunization. chickenpox, virus, pneumonia, encephalopathy, vaccine, events, dissemination.