A5004074820- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Health and Lifestyle Studies
- Adrenal Hormones and Disorders
- Systemic Sclerosis and Related Diseases
- Vitamin D Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Immunodeficiency and Autoimmune Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- T-cell and B-cell Immunology
- Galectins and Cancer Biology
- Inflammasome and immune disorders
- Renal Diseases and Glomerulopathies
- Diabetes and associated disorders
- Autoimmune and Inflammatory Disorders Research
- Oral Health Pathology and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Diagnosis and Treatment of Venous Diseases
- Dermatologic Treatments and Research
- Sexual Differentiation and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Hormonal and reproductive studies
- Vasculitis and related conditions
- Glycosylation and Glycoproteins Research
- Social Skills and Education
Universidad Nacional de Asunción
2014-2025
Hospital General Universitario Gregorio Marañón
2024
Hospital de Clínicas
2016-2023
University College London
2022
Consejo Nacional de Ciencia y Tecnología
2020
Emory University
2020
Background. Because of ongoing outbreaks varicella, a second dose varicella vaccine was added to the routine immunization schedule for children in June 2006 by Centers Disease Control and Prevention. Methods. We assessed effectiveness 2 doses case-control study identifying ≥4 years age with confirmed polymerase chain reaction assay up controls matched pediatric practice. Effectiveness calculated using exact conditional logistic regression. Results. From July January 2010, 71 case subjects...
What baseline predictors would be involved in mortality people with primary Sjögren syndrome (SjS) remains uncertain. This study aimed to investigate the characteristics collected at time of diagnosis SjS associated and identify risk factors for all-cause death deaths related systemic activity measured by ESSDAI score.In this international, real-world, retrospective, cohort study, we retrospectively data from 27 countries on causes Big Data Registry. Inclusion criteria consisted fulfilling...
El agua potable, considerada como derecho humano, plantea a Latinoamérica, y en especial Paraguay, la necesidad de ejecución políticas públicas que aseguren el acceso al líquido vital términos cantidad, calidad, continuidad costo para población manera equitativa todos los sectores sociales, pues constituye uno objetivos del desarrollo sostenible (Objetivo 6: limpia saneamiento). presente trabajo investigación tuvo objetivo analizar gestión ciudad Caaguazú, enfocándose organización, calidad...
La vitamina D es una hormona cumple funcion en la regulacion de numerosos genes que participan proliferacion y maduracion celular. El objetivo este trabajo fue determinar prevalencia valores inadecuados esta jovenes sanos Asuncion e identificar los posibles factores riesgo asociados. Estudio observacional descriptivo basado datos clinico-epidemiologicos determinacion 25-hidroxivitamina (25-OH D) por el metodo quimioluminiscencia (CMIA). Se considero valor adecuado ≥30 ng/dl, inadecuado...
Long-term outcome studies after pediatric cardiac arrest (CA) are few. They require a CA registry and dedicated teams. Learning about the long-term outcomes is very important for developing prognostication guidelines, improving post-cardiac care, counseling caregivers future of their child, creating opportunities therapeutic intervention to improve outcomes. Few PICUs worldwide provide multidisciplinary follow-up program as routine practice at an outpatient clinic with standardized...
<h3>Background:</h3> Lupus nephritis (LN) is one of the most common, serious manifestations systemic lupus erythematosus (SLE) and associated with significant morbidity mortality. <h3>Objectives:</h3> To evaluate work productivity (WP) activity impairment (AI) in patients active LN at cohort entry 12 months after treatment initiation according to their renal response. <h3>Methods:</h3> GLADEL 2.0 an observational prevalent incident cohort. Forty-four centers from Latin-American countries...
<h3>Background:</h3> Neurological manifestations can occur in up to half of patients with Sjögren disease (SjD) and the peripheral nervous system (PNS) is most commonly involved (5-21%). <h3>Objectives:</h3> To analyze frequency phenotypic expression PNS involvement at time SjD diagnosis <h3>Methods:</h3> The Big Data Project Consortium an international, multicenter registry created 2014. Baseline clinical information from leading centers on research five continents was collected as a first...
<h3>Background:</h3> Central nervous system (CNS) involvement is one of the numerous extra-glandular manifestations primary Sjögren disease (SjD) and it has been described in 8-70% patients at various stages disease. <h3>Objectives:</h3> To characterize how CNS presents diagnosis SjD. <h3>Methods:</h3> The Big Data Consortium an international, multicentre registry created 2014. Baseline clinical information from leading centers on research SjD five continents was collected as a first step....
<h3>Background:</h3> Pulmonary manifestations of primary Sjögren disease (SD) have been described in 9-20% patients, are highly heterogeneous and also linked to increased mortality. <h3>Objectives:</h3> To characterize pulmonary a large cohort patients with SD. <h3>Methods:</h3> We collected data on SD from the international Big Data Registry. Inclusion criteria were fulfilling 2002/2016 classification having had at least once (defined as an ESSDAI score ≥5 domain).. <h3>Results:</h3> A...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by heterogeneous clinical picture that makes the diagnosis and follow-up of these patients difficult. This study aimed to identify correlations between clinical, immunological, genetic biomarkers manifestations in SLE. A retrospective data from medical records immunological studies SLE Paraguay was carried out. descriptive analysis performed based on type variable. Human leukocyte antigen (HLA) allele...
To assess the prevalence of parotid gland swelling (PGS) and its association with features SS other causes sialadenosis in a Latin-American cohort primary SS.We included 668 patients from Argentina, Brazil, Mexico Paraguay. We retrospectively registered demographics, disease duration, oral/ocular symptoms, serology scored basal ESSDAI. defined PGS as recurrent or persistent increase volume any glands during adulthood (self-reported and/or physical examination). presence diabetes mellitus,...
El lupus eritematoso sistémico (LES) es una enfermedad autoinmune, de etiología desconocida que presenta manifestaciones clínicas gravedad y curso impredecible. Se ha observado en varias cohortes esta tiene un comportamiento más agresivo la población no caucásica debido a diferencias socioeconómicas, demográficas genéticas. objetivo del estudio describir las características clínico-epidemiológicas los pacientes con LES incluidos cohorte LUPUS-PY situación actual muestras custodiadas el...
Bernal, Cynthia Biochemist; Acosta Colmán, Isabel PhD; Cardozo, Fátima MSc; Waggoner, Jesse J. MD; Cantero, César Acosta, Ma. Eugenia Aria, Laura Analytical Chemist; de Guillén, Yvalena Mendoza, Patricia Páez, Malvina Vázquez, Marcos Duarte, Margarita Rojas, Alejandra MSc Author Information
Genetic and nongenetic factors are involved in the pathogenesis of immune-mediated inflammatory diseases (IMIDs). The best-known genetic factor for susceptibility to IMIDs is human leukocyte antigen (HLA). aim present study was evaluate association HLA class II genes with risk systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), sclerosis (SSc) Paraguayan population. We included 254 patients (101 SLE, 103 RA, 50 SSc) healthy controls. haplotypes five corresponding their...
Resumen: La cetoacidosis diabética (CAD) es una de las complicaciones agudas severas la diabetes mellitus.La mayoría los pacientes con CAD ??tienen autoinmune tipo 1, sin embargo, 2 (DM2) también están en riesgo padecerla durante el estrés catabólico enfermedad aguda como traumatismo, cirugía o infección.Se presenta serie 20 casos donde se diagnosticó sujetos DM2, edad media fue 62 años, todas eran mujeres, cuya principal causa precipitante infección.La forma clínica moderada (85%) predominante.
de mujer con fenotipo femenino pero cariotipo 46XY, que genera una insensibilidad completa a los andrógenos Palabras claves: síndrome andrógenos, amenorrea primaria Abstract: we report the case of woman with female phenotype, but 46, XY karyotype, that generates complete androgen insensitivity.
<h3>Background</h3> Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by very heterogeneous clinical picture that makes diagnosis and follow-up of these patients difficult. <h3>Objectives</h3> Identify correlations between clinical, immunological genetic biomarkers with manifestations in SLE Paraguayan patients. <h3>Methods</h3> Retrospective study data from medical records studies Paraguay. A descriptive analysis was performed based on the type variable. HLA...
G A b st ra ct s (1991-1995) as our true negative population (n=936,514).We linked to health administrative data and compared the accuracy of various algorithms services patterns establish which best identified children with IBD. To validate for <18y seen throughout Ontario, charts 593 patients IBD (diagnosed 2001-2005) 1241 without were reviewed from 12 diverse practices province. RESULTS: two-step algorithm based on whether underwent diagnostic colonoscopy was most accurate. Patients who...