A5012336852- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Vasculitis and related conditions
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Autoimmune and Inflammatory Disorders Research
- Peripheral Neuropathies and Disorders
- Renal Diseases and Glomerulopathies
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Diabetes and associated disorders
- Lymphoma Diagnosis and Treatment
- Intramuscular injections and effects
- Pharmacological Effects of Natural Compounds
- Whipple's Disease and Interleukins
- Dermatological and COVID-19 studies
- Long-Term Effects of COVID-19
- Cytokine Signaling Pathways and Interactions
- Heparin-Induced Thrombocytopenia and Thrombosis
- Leprosy Research and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Hematological disorders and diagnostics
Universidade Federal de São Paulo
2016-2025
Hospital São Paulo
2017-2023
Universidade de São Paulo
2017-2023
Universidade Federal de Minas Gerais
2007-2022
Fundação Oswaldo Cruz
2022
Universidade Federal do Rio Grande do Sul
2014-2022
Universidade Federal do Espírito Santo
2022
Universidade Federal de Juiz de Fora
2022
El Hospital General de Agudos Carlos G. Durand
2020
Universidade Estadual de Campinas (UNICAMP)
2019
To identify features of antinuclear antibody (ANA)-HEp-2 test results that discriminate ANA-positive healthy individuals and patients with autoimmune rheumatic diseases (ARDs).We sequentially retrieved data on 918 153 ARDs after clinical assessment. for whom were available reevaluated 3.6-5.0 years. An ANA-HEp-2 result was considered positive when a clear ANA pattern observed at 1:80 dilution in 2 distinct commercial HEp-2 slides by blinded independent observers.ANAs present 118 (12.9%) 138...
To evaluate the beneficial effect of antimalarial treatment on lupus survival in a large, multiethnic, international longitudinal inception cohort.Socioeconomic and demographic characteristics, clinical manifestations, classification criteria, laboratory findings, variables were examined patients with systemic erythematosus (SLE) from Grupo Latino Americano de Estudio del Lupus Eritematoso (GLADEL) cohort. The diagnosis SLE, according to American College Rheumatology was assessed within 2...
Objectives: To investigate mortality, cause of death, and risk factors related to mortality in Japanese patients with rheumatoid arthritis (RA).Methods: The IORRA cohort is a large observational established 2000 at the Institute Rheumatology, Tokyo Women's Medical University. Essentially, all RA were registered clinical parameters assessed biannually. For who failed participate subsequent surveys, simple queries mailed confirm survival. Standardized ratios (SMRs) calculated analysed using...
Systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune disease, represents significant challenge for both diagnosis treatment. Patients with SLE in Latin America face special problems that should be considered when therapeutic guidelines are developed. The objective of the study is to develop clinical practice American patients lupus. Two independent teams (rheumatologists experience management methodologists) had an initial meeting Panama City, Panama, April 2016. They...
To evaluate disease activity statuses' (DAS') impact on systemic lupus erythematosus (SLE) outcomes.Four DAS were defined: remission off-therapy: SLE Disease Activity Index (SLEDAI)=0, no prednisone or immunosuppressive drugs (IS); on-therapy: SLEDAI=0, ≤5 mg/day and/or IS (maintenance); low (L) DAS: SLEDAI ≤4, ≤7.5 non-optimally controlled: >4 >7.5 (induction). Antimalarials allowed in all. Predefined outcomes mortality, new damage (increase of at least one Systemic Lupus International...
Abstract Objective To determine if supervised cardiovascular training improves exercise tolerance, aerobic capacity, depression, functional and quality of life in patients with systemic lupus erythematosus (SLE). Methods Sixty women SLE (ages 18–55 years) were evaluated using Short Form 36, visual analog scale for pain, fatigue, Beck Depression Inventory, Health Assessment Questionnaire (HAQ), participated a protocol incremental load on treadmill computed gas metabolic analysis. Maximum...
Patients with systemic lupus erythematosus (SLE) have recognized reduction in endothelium-dependent vasodilation. Evidence demonstrates that statins are able to improve endothelial function independently on their hypolipemic action.To evaluate the efficacy of atorvastatin improving vasodilation SLE patients and without conventional risk factors for coronary heart disease (CHD).Sixty-four women, mean age 31 +/- 8 yrs, received 20 mg/day during weeks. Thirty-one this intervention group did not...
Vessel wall inflammation, atherosclerosis and hypercoagulability may be responsible for ischemic events in Takayasu arteritis (TA). No study has evaluated the effect of antiplatelet therapy prevention TA.Forty-eight patients who met ACR Classification Criteria TA under follow-up at Vasculitis Unit Universidade Federal de São Paulo were retrospectively clinical manifestations, arterial events. The mean age was 38.0 years diagnosis 29.1 years. Women comprised 89.6% 60.4% Caucasian. Risk...
Objectives. To evaluate the effectiveness and safety of tocilizumab in RA patients clinical practice. Methods. We observed 232 consecutive who began three rheumatology centres Japan for 52 weeks. Clinical, radiographic functional status were evaluated. Results. Mean age was 59.1 years, mean duration disease 12.4 years average DAS using 28-joint count (DAS-28) 5.6. Although 62.8% had been treated previously with anti-TNF biologics, remission at Week achieved 43.7%, non-progression 26.4%....
Objective. To analyze the mortality profile related to systemic lupus erythematosus (SLE) in state of São Paulo, Brazil. Methods. For 1985–2007 period, we analyzed all death certificates (n = 4815) on which SLE was listed as an underlying 3133) or non-underlying 1682) cause death. We evaluated sex, age, and causes death, comparing first last 5 years well determining observed/expected ratio (O/E ratio). Results. cause, mean age at 35.77 (SD 15.12) main were renal failure, circulatory system...
Aim The aim of this study was to identify factors predictive serious infections over time in patients with systemic lupus erythematosus (SLE). Methods A multi-ethnic, multi-national Latin American SLE cohort studied. Serious infection defined as one that required hospitalization, occurred during a hospitalization or led death. Potential predictors included were sociodemographic factors, clinical manifestations (per organ involved, lymphopenia and leukopenia, independently) previous at...
The objective of the study was to evaluate incidence Systemic Lupus Erythematosus (SLE) in a tropical urban community (Natal city, Brazil). Only patients living Natal, city northeastern area Brazil, older than 15 years, and who fulfilled at least four American College Rheumatology criteria between 1 January 2000 31 December 2000, were included. Four sources used identify new cases SLE: (1) University Hospital; (2) 'health units' hospitals public health network; (3) specialists private...
Abstract Objective To evaluate the efficacy of clofazimine (CFZ) compared with chloroquine diphosphate (CDP) for treatment cutaneous involvement in systemic lupus erythematosus (SLE). Methods A prospective, randomized, controlled, double‐blind clinical trial was carried out SLE patients active lesions, whom 16 were randomized to receive CFZ at 100 mg/day and 17 received CDP 250 6 months. All drugs had a similar appearance avoid identification. Both groups broad‐spectrum sunscreens twice day...
This study aimed to evaluate the association between nailfold capillary abnormalities and presence of Raynaud's phenomenon (RP), anti-U1-RNP, anti-cardiolipin (aCL) antibodies in SLE patients. One-hundred patients were studied. Widefield capillaroscopy was considered abnormal according five criteria. Intercapillary distance, width length registered by videomorphometry two fingers 100 four 40 these Both alterated scleroderma-pattern (SD-pattern), characterized avascular areas enlarged or...
To develop recommendations for the diagnosis, management and treatment of lupus nephritis in Brazil.Extensive literature review with a selection papers based on strength scientific evidence opinion Commission Systemic Lupus Erythematosus members, Brazilian Society Rheumatology.1) Renal biopsy should be performed whenever possible if this procedure is indicated; and, when not possible, guided inference histologic class. 2) Ideally, measures precautions implemented before starting treatment,...
To evaluate rheumatoid arthritis (RA)-related mortality in the state of São Paulo (Brazil).Data from all death certificates (DC) 1996 to 2010 were analyzed using a multiple cause-of-death method. We compared results 2 subperiods (1996-2000 and 2006-2010).We found 3955 DC related RA - 27.6% with as underlying cause (UCD) 72.4% nonunderlying (NUCD). Ninety percent RA-related deaths occurred at age ≥ 50 years. The mean ages 67.1 ± 13.3 67.9 13 years for UCD NUCD, respectively. most frequent...
Systemic Lupus Erythematosus (SLE) is an autoimmune disease which impairs the quality of life. The objective study was to evaluate effectiveness Brief Group Psychoanalytic Psychotherapy improve life, depression, anxiety and coping strategies in SLE patients. In a randomized clinical trial, 80 female patients were allocated into two groups: therapy group (n = 37) control 43). Therapy (TG) attended weekly psychotherapy sessions for 20 weeks; (CG) remained on waiting list. Both groups received...
Objective: To evaluate the humoral response to and impact of SARS-CoV-2 vaccination in patients with systemic lupus erythematosus a multicenter cohort design. Methods: Data for this analysis were obtained from Study Safety, Effectiveness Duration Immunity after Vaccination against Patients Immune-Mediated Inflammatory Diseases (SAFER), prospective, multicenter, phase IV, real-world study conducted across different regions Brazil June/2021 March/2024. aged >18 years (SLE) who received any...