A5019790149- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Vasculitis and related conditions
- Atherosclerosis and Cardiovascular Diseases
- IgG4-Related and Inflammatory Diseases
- Monoclonal and Polyclonal Antibodies Research
- Ocular Diseases and Behçet’s Syndrome
- Autoimmune Bullous Skin Diseases
- Otitis Media and Relapsing Polychondritis
- SARS-CoV-2 and COVID-19 Research
- Blood Coagulation and Thrombosis Mechanisms
- Diabetes and associated disorders
- Gastrointestinal disorders and treatments
- Long-Term Effects of COVID-19
- Immunodeficiency and Autoimmune Disorders
- Intramuscular injections and effects
- COVID-19 and Mental Health
- Drug-Induced Ocular Toxicity
- Vitamin C and Antioxidants Research
- Skin Diseases and Diabetes
- Neuroendocrine Tumor Research Advances
- Sepsis Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
Universidad de la República de Uruguay
2014-2025
Hospital de Clínicas
2012-2025
Institut Pasteur de Montevideo
2020-2023
Mutualista Hospital Evangélico
2021-2023
Hospital del Salvador
2022
Hospital Privado
2022
Universidad de Montevideo
2008-2018
Universidad La República
2008-2018
Adaptimmune (United Kingdom)
2018
Hospital Clínic de Barcelona
2014
The influence of antimalarials on lipids in systemic lupus erythematosus (SLE) has been identified several studies but not many prospective cohorts. aim this study was to longitudinally determine the effect lipoprotein profile SLE. Patients and methods: Fasting total cholesterol (TC), triglycerides (TG), high-density (HDL) low-density (LDL) plasma levels were determined at entry after 3 months hydroxychloroquine (HCQ) treatment a longitudinal evaluation 24 patients with Results: significant...
Systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune disease, represents significant challenge for both diagnosis treatment. Patients with SLE in Latin America face special problems that should be considered when therapeutic guidelines are developed. The objective of the study is to develop clinical practice American patients lupus. Two independent teams (rheumatologists experience management methodologists) had an initial meeting Panama City, Panama, April 2016. They...
Antimalarials have demonstrated beneficial effects in Systemic Lupus Erithematosus and Rheumatoid Arthritis. However, the mechanisms molecular players targeted by these drugs remain obscure. Although hydroxychloroquine (HCQ) is a known ion channel inhibitor, this property has not been linked to its anti-inflammatory effects. We aimed study whether HCQ inhibits pro-inflammatory channels. Electrophysiology experiments that inhibited Ca++-activated K+ conductance THP-1 macrophages...
Background. End-stage renal disease (ESRD) is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Objectives. To analyze the outcome prognostic factors transplantation ESRD due to SLE from January 1986 December 2013 a single center. Results. Fifty transplantations were performed 40 (32 female (80%), mean age at 36 ± 10.4 years). The most frequent nephropathy was type IV (72.2%). Graft failure occurred total 15 (30%) causes graft chronic...
Introduction The use of hydroxychloroquine (HCQ) in patients with systemic lupus erythematosus (SLE) offers a wide range benefits. However, there are evidence favour cardiotoxicity, including heart conduction disturbances and congestive failure. Objective To determine the effects HCQ resting rate (RHR) SLE patients. Patients methods Included were non active SLE, sedentary lifestyle treated HCQ. Excluded on beta blocker treatment, trained patients, pacemaker´s users clinical or analytical...
The authors report an electrochemical biosensor enabling fast (30 min) detection of anti-DNA antibodies in serum with reduced manipulation steps.
Systemic lupus erythematosus (SLE) disproportionately affects Latin American and Latino populations, with worse outcomes compared to nonminority populations. Understanding patients' views is critical provide culturally competent care. The objective of this research analyze lived experiences SLE from comments made by patients, their relatives friends, on the public Facebook group "Hablemos de Lupus" (in English: "Let's Talk about Lupus").Deidentified narratives posted as a reaction most...
Background/Objective Data on IgG4-related disease (IgG4-RD) come almost exclusively from cohorts Asia, Europe, and North America. We conducted this study to describe the clinical presentation, phenotype distribution, association with sex, ethnicity, serological markers in a large cohort of Latin American patients IgG4-RD. Methods performed multicenter medical records review including 184 IgG4-RD patients. assigned phenotypes: group 1 (pancreato-hepato-biliary), 2 (retroperitoneal/aortic), 3...
Background/Objective The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria (2019 AECC) for IgG4-related disease (IgG4-RD) is considered a significant advancement in the study this condition. Most studies evaluating their performance have focused on White and Asian patients, leaving knowledge gap regarding Latin populations. Therefore, aimed to assess AECC IgG4-RD cohort patients. Methods A multicenter medical records review was conducted,...
Adenosine triphosphate (ATP) is released by alveolar epithelial cells during ventilator-induced lung injury (VILI) and regulates fluid transport across epithelia. High CO2 levels are observed in patients with “permissive hypercapnia,” which inhibits reabsorption (AFR) cells. The authors set out to determine whether VILI affects AFR the purinergic pathway modulated exposed hypercapnia. Control group was compared against (tidal volume [Vt] = 35 mL/kg, zero positive end-expiratory pressure...
Introduction: After more than 20 years of sustained work, the Latin American Group for Study Lupus (GLADEL) has made a significant number contributions to field lupus, not only in differential role that race/ethnicity plays its course and outcome but also several other studies including beneficial effects using antimalarials lupus patients development consensus guidelines treatment our region. Methods: A new generation “Lupus Investigators” 40 centers throughout America been constituted...
We report the development of an immuno-lectin-enzymatic assay (CA83.4) with purpose quantifying serum glycoproteins bearing Tn determinant (GalNAc alpha-O-Ser/Thr). An anti-Tn monoclonal antibody (83D4) is bound to solid phase in order capture glycoproteins. After addition a test sample, we used biotinylated isolectin B4 from Vicia villosa and avidin-peroxydase act as detection system. The linear relationship between CA83.4 determinations dilutions, reproducibility dosage intra- inter-assay,...
Necrotizing fasciitis is a rapidly progressive destructive soft tissue infection with high mortality. Streptococcus pneumoniae as etiologic agent of necrotizing extremely unusual. The increased susceptibility to in patients systemic lupus erythematosus probably multifactorial phenomenon. We report case patient, 36-year-old Caucasian female 8-year history who presented fatal fasciitis. role computed tomography and the performance blood cultures for isolation causative microorganism are...