A5061481641- Systemic Lupus Erythematosus Research
- Building Energy and Comfort Optimization
- Urban Arborization and Environmental Studies
- Atherosclerosis and Cardiovascular Diseases
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Multiple Sclerosis Research Studies
- MicroRNA in disease regulation
- Noise Effects and Management
- Solar Energy Systems and Technologies
- Urban Heat Island Mitigation
- Sustainable Building Design and Assessment
- Environmental Sustainability and Education
- Renal Diseases and Glomerulopathies
- Lymphoma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Infectious Diseases and Tuberculosis
- Multiple Myeloma Research and Treatments
- Solar Thermal and Photovoltaic Systems
- Computational Drug Discovery Methods
- Diabetes and associated disorders
- Single-cell and spatial transcriptomics
- Health, Environment, Cognitive Aging
- Healthcare Regulation
Hospital das Clínicas da Universidade Federal de Pernambuco
1994-2024
Universidade Federal de Alagoas
2020-2024
Urbana University
2023
Universidade de São Paulo
2023
Oryzon Genomics (Spain)
2016-2022
Cornell University
2016-2022
Universidade Federal de Pernambuco
1994-2018
National University of Rosario
2012
Hospital Privado
2012
Hospital Provincial de Rosario
2012
Systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune disease, represents significant challenge for both diagnosis treatment. Patients with SLE in Latin America face special problems that should be considered when therapeutic guidelines are developed. The objective of the study is to develop clinical practice American patients lupus. Two independent teams (rheumatologists experience management methodologists) had an initial meeting Panama City, Panama, April 2016. They...
Transcription disequilibria are characteristic of many neurodegenerative diseases. The activity-evoked transcription immediate early genes (IEGs), important for neuronal plasticity, memory and behavior, is altered in CNS diseases governed by epigenetic modulation. KDM1A, a histone 3 lysine 4 demethylase that forms part regulation complexes, has been implicated the control IEG transcription. Here we report development vafidemstat (ORY-2001), brain penetrant inhibitor KDM1A MAOB. ORY-2001...
To examine the role of ethnicity and use anti-malarials (protective) on lupus renal disease.A nested case-control study (1:2 proportion, n = 265 530) within GLADEL's (Grupo Latino Americano De Estudio de Lupus) longitudinal inception cohort was carried out. The end-point ACR criterion development after diagnosis. Cases controls were matched for follow-up time (end-point or a comparable time, respectively). Renal disease predictors examined by univariable multivariable analyses. Additional...
Aim A decrease in proteinuria has been considered protective from renal damage lupus nephritis (LN), but a cut-off point yet to be established. The aim of this study was identify the predictors patients with LN and determine best for proteinuria. Methods We included defined clinically or histologically. Possible at time diagnosis were examined: proteinuria, low complement, anti-double-stranded DNA antibodies, red cell casts, creatinine level, hypertension, activity (assessed by Systemic...
Objective: The objective of this paper is to examine the role place residency in expression and outcomes systemic lupus erythematosus (SLE) a multi-ethnic Latin American cohort. Patients methods: SLE patients (<two years diagnosis) from 34 centers constitute Residency was dichotomized into rural urban, cut-off: 10,000 inhabitants. Socio-demographic, clinical/laboratory mortality rates were compared between them using descriptive tests. influence on disease activity at diagnosis renal...
The therapeutic potential of drugs that block the induction cyclooxygenase-2 has been emphasized. When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic (HTB)] were compared with aspirin sodium as (COX-2) inhibitors, we observed in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, HTB, but not salicylate, inhibited COX-2-mediated prostaglandin E2 (PGE2)...
This study is a cross-sectional analysis of the differences between SLE outpatients seen in Rheumatology departments at University centres England, Brazil and Sweden, using standard protocol. The demographic characteristics, extent activity disease 209 patients with were studied; 112 33 64 Sweden. median age onset Brazilian English was 25 years Swedish 31.5 years. Disease measured by BILAG index. In most systems experienced more than patients. Non-Caucasians active Caucasians. No sex or...
Introduction: After more than 20 years of sustained work, the Latin American Group for Study Lupus (GLADEL) has made a significant number contributions to field lupus, not only in differential role that race/ethnicity plays its course and outcome but also several other studies including beneficial effects using antimalarials lupus patients development consensus guidelines treatment our region. Methods: A new generation “Lupus Investigators” 40 centers throughout America been constituted...
Lysine specific demethylase 1 (LSD1; also known as KDM1A), is an epigenetic modulator that modifies the histone methylation status. KDM1A forms a part of protein complexes regulate expression genes involved in onset and progression diseases such cancer, central nervous system (CNS) disorders, viral infections, others. Vafidemstat (ORY-2001) clinical stage inhibitor development for treatment neurodegenerative psychiatric diseases. However, role ORY-2001 targeting neuroinflammation remains to...
ORY-2001 is a brain-penetrable inhibitor of LSD1 and MAO-B with excellent oral bioavailability PK profile. chromatin modulator component repressor complexes. plays an important role in the catabolism neuroactive vasoactive amines responsible for dopamine degradation. has selectivity over other FAD containing amine oxidases, does not inhibit modulators nor +100 targets from CEREP diversity panel. development treatment CNS disorders, including Alzheimer's Phase I trial healthy young elderly...
The acquisition of low density by lymphocytes is the earliest detectable marker their activation and may be utilized for separation quantification these cells. Low (LDL) are found in increased numbers patients with rheumatoid arthritis compared healthy controls (p less than 0.05). number LDL raised who failed to respond clinically gold or D-penicillamine when those did 0.05), latter group having values normal range. Sequential studies have shown that successful antirheumatic therapy...
<h3>Background</h3> Neuropsychiatric (NP) manifestations of systemic lupus erythematosus (SLE) are an important source morbidity, functional impairment and poor quality life. Several investigators have examined predictors overall damage accrual in SLE, but NP-damage been infrequently evaluated. The aim this study was to assess the socio-demographic disease related factors predictive occurrence its impact on mortality Latin-American SLE patients with early disease. <h3>Materials methods</h3>...
Factors related to presentation of neuropsychiatric (NP) SLE manifestations, early in the course disease, and during follow up have not been clearly established.To identify disease non-disease factors associated with NP manifestations SLE.We included 1193 patients from GLADEL inception cohort free involvement at entry. We evaluated association demographic, clinical laboratory data follow-up.Independent were identified using a multivariable Cox regression model.Factors independently were:...
<h3>Background</h3> Obstetric morbidity (OM) is higher in SLE women than healthy ones. Few data on pregnancy outcomes Latin America (LA) have been reported. <h3>Objectives</h3> To study LA. <h3>Methods</h3> GLADEL 2.0 an observational prevalent/incident cohort started 2019. date, 43 centers from 10 LA countries enrolled 1030 patients (1982/1997 ACR or SLICC criteria). Women with ≥1 were included. Past and ongoing (6, 12, 24 months follow-up) OM (miscarriages, fetal deaths, preeclampsia,...
<h3>Background</h3> Obstetric morbidity (OM) is higher in SLE women than healthy ones. Few data on pregnancy outcomes Latin America (LA) have been reported. <h3>Objectives</h3> To study LA. <h3>Methods</h3> GLADEL 2.0 an observational prevalent/incident cohort started 2019. date, 43 centers from 10 LA countries enrolled 1030 patients (1982/1997 ACR or SLICC criteria). Women with ≥1 were included. Past and ongoing (6, 12, 24 months follow-up) OM (miscarriages, fetal deaths, preeclampsia,...
<h3>Background</h3> Systemic Lupus Erythematosus (SLE) patients experience frequent hospitalizations; lupus flares and infections have been shown to be the two most common causes. <h3>Objectives</h3> The aim of this study is describe main causes predictors first hospitalizations due disease activity in SLE patients. <h3>Methods</h3> from GLADEL, a multi-ethnic, multi-national Latin-American (LA) cohort were studied. hospitalization during these patients' follow-up either infection and/or was...
To identify the predictive factors of first hospitalization and associated variables to main causes hospitalizations in lupus patients from a Latin American cohort.
Este artigo oferece um panorama sobre a integração de princípios bioclimáticos nos processos contemporâneos design urbano, visando promover sustentabilidade ambiental espaços livres. A Revisão Sistemática Literatura analisa produção científica global dos últimos cinco anos o tema, concentrando-se na base dados Web of Science. Os resultados mostram uma incidência maior trabalhos entre 2022 e 2023 estão alinhados com os seguintes objetivos: identificar estudos que abordem no urbano analisar...
Este artigo avaliou o desempenho térmico de uma edificação multifamiliar vertical considerando os cenários mudanças climáticas para 2050 e 2080. Esta avaliação ocorreu com auxílio simulações computacionais no software EnergyPlus, um modelo padrão, sistemas construtivos adotados pela indústria da construção civil aplicados nos diversos climas zonas bioclimáticas brasileiras. Levou-se em consideração as condições predições que planeta enfrenta. Para avaliados, embora tenha sido considerado...
Estudos recentes apontam uma ligação intrínseca entre o conforto térmico oferecido pelo ambiente e os níveis de concentração, desempenho aprendizagem alcançados por seus usuários. Nas instituições públicas ensino, edificações onde as restrições orçamentárias comumente tornam proibitivo uso da climatização artificial, a obtenção do depende primordialmente estratégias passivas climatização, exemplo ventilação natural. O objetivo deste trabalho é avaliar impacto velocidade ar no sala aula...
Este artigo avaliou o desempenho térmico de dois sistemas coberturas para uma edificação multifamiliar considerando os procedimentos recomendados pela NBR-15575. Esta análise se deu as oito zonas bioclimáticas brasileiras observando percentual horas ocupadas dentro da faixa temperatura operativa e temperaturas operativas mínimas máximas (PHFTUH Tomín Tomáx) padrão, com telhas cerâmicas modelo telha fibrocimento, levando em consideração envelhecimento destes três anos uso conforme...
A doença de Castleman (DC) é uma linfoproliferativa não neoplásica rara, etiologia desconhecida, que se caracteriza clinicamente por adenomegalias isoladas ou múltiplas, podendo estar associada a sintomas sistêmicos, como febre e perda peso. Estes podem levar um diagnóstico equivocado auto-imune o diferencial deve ser feito através exame anatomopatológico do linfonodo acometido, caracteristicamente, na DC, mostra padrão células plasmáticas com infiltrado hialino. Os autores relatam caso...