A5082932483- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Long-Term Effects of COVID-19
- Dermatological and COVID-19 studies
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Systemic Sclerosis and Related Diseases
- Atherosclerosis and Cardiovascular Diseases
- Peripheral Neuropathies and Disorders
- Rheumatoid Arthritis Research and Therapies
- Renal Diseases and Glomerulopathies
- Healthcare professionals’ stress and burnout
- Inflammasome and immune disorders
- COVID-19 and healthcare impacts
- Pharmacological Effects of Natural Compounds
- Parvovirus B19 Infection Studies
- Musculoskeletal pain and rehabilitation
- Liver Disease Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Salivary Gland Disorders and Functions
- Vitamin C and Antioxidants Research
- Healthcare Regulation
- Immune Cell Function and Interaction
- Infectious Encephalopathies and Encephalitis
Universidade Federal de São Paulo
2013-2025
ORCID
2023
University Center of Brasília
2022
Hospital São Paulo
2020-2021
Hospital Alemão Oswaldo Cruz
2021
Fundação de Apoio à Universidade Federal de São Paulo
2021
Instituto Barretos de Tecnologia
2020
Hospital das Clínicas da Universidade Federal de Pernambuco
2020
Centro Universitário São Camilo
2015
Objectives To evaluate risk factors associated with unfavourable outcomes: emergency care, hospitalisation, admission to intensive care unit (ICU), mechanical ventilation and death in patients immune-mediated rheumatic disease (IMRD) COVID-19. Methods Analysis of the first 8 weeks observational multicentre prospective cohort study (ReumaCoV Brasil register). Patients IMRD COVID-19 according Ministry Health criteria were classified as eligible for study. Results 334 participants enrolled, a...
Objective: To evaluate the humoral response to and impact of SARS-CoV-2 vaccination in patients with systemic lupus erythematosus a multicenter cohort design. Methods: Data for this analysis were obtained from Study Safety, Effectiveness Duration Immunity after Vaccination against Patients Immune-Mediated Inflammatory Diseases (SAFER), prospective, multicenter, phase IV, real-world study conducted across different regions Brazil June/2021 March/2024. aged >18 years (SLE) who received any...
Objective. The objective of this study was to evaluate the effect supervised physical exercise on endothelial function, ergospirometric test variables and disease activity in SLE patients. Methods. We conducted a prospective which women with who were available perform allocated group (EG) practise for 1 h three times per week 16 weeks. Those not control (CG). Intervention consisted walking at heart rate corresponding ventilatory threshold obtained from ergospirometry monitored by frequency...
Abstract Objectives To compare the impact of COVID-19 on clinical status and psychological distress patients with immune-mediated rheumatic disease (IMRD) caused by SARS-CoV-2 infection that noninfected IMRD controls during a 6-month follow-up period. Methods The ReumaCoV Brazil is longitudinal study designed to follow for 6 months after (patients) compared without (controls). Clinical data, activity measurements current treatments regarding outcomes were evaluated in all patients. Disease...
Objectives Primary: To validate a previously developed lupus nephritis (LN) histologic class predictor tool (III or IV±(V) vs V). In this instrument, urinary sediment, anti-dsDNA antibody and serum creatinine were variables. Secondary: evaluate its accuracy in different cut levels of red cell count LN patient’s profile that may be useful to guide diagnosis treatment, especially when kidney biopsy is not available. Methods A retrospective, cross-sectional study 196 patients with SLE who...
Patients with immune-mediated rheumatic diseases (IMRD) are at increased risk of infections, including significant morbidity and high mortality. Considering the potential for unfavorable outcomes SARS-CoV-2 infection in patients IMRD, several questions were raised regarding impact COVID-19 start pandemic.This paper presents protocol a study that aims to prospectively evaluate IMRD confirmed diagnosis (using criteria provided by Brazilian Ministry Health).The comprised prospective,...
Background Acute exercise increases IL-6, IL-10 and TNF-α levels in healthy subjects. There is no study evaluating the effect of on cytokines level systemic lupus erythematosus (SLE) patients. Objective Our aim was to assess IL-10, IL-6 at baseline after acute physical patients with SLE. Methods In total, 27 female SLE 30 controls were evaluated. Serum soon ergospirometric test measured by ELISA test. Student's t-tests Mann–Whitney used for intra- inter-group comparisons; p values <0.05...
To determine the incidence of positive CMV antigenemia (CMV-Ag) in patients with autoimmune rheumatic diseases (AIRD) and to describe outcomes these patients. From January 2011 December 2014, a total 443 AIRD were enrolled this retrospective analysis. Demographic, clinical laboratory data, current manifestations, organs affected by infection, therapeutic management evaluated. The CMV-Ag was considered when one cell detected at least. requested 70 (15.8%) suspicious infection 24 (34.3%). rate...
To evaluate the impact and risk factors associated with an abnormal exercise test (ET) in systemic inflammatory rheumatic disease (SIRD) patients before commencing supervised physical exercise.A total of 235 SIRD were enrolled three controlled clinical trials, including 103 RA, 42 SLE 57 AS patients. The control group consisted 231 healthy, sedentary subjects matched for age, gender BMI. All performed ET, according to Bruce's or Ellestad's protocol. Cardiovascular factors, medications,...
Abstract Background There is a lack of information on the role chronic use hydroxychloroquine during SARS-CoV-2 outbreak. Our aim was to compare occurrence COVID-19 between rheumatic disease patients with individuals from same household not taking drug first 8 weeks community viral transmission in Brazil. Methods This baseline cross-sectional analysis part 24-week observational multi-center study involving 22 Brazilian academic outpatient centers. All regarding symptoms, epidemiological,...
Objectives to evaluate the main factors associated with mortality and determine life expectancy of SLE patients between 2000 2019 years in Brazil. Methods death data related available Brazilian Unified Health System (SUS) (DATASUS) were evaluated all states. Three groups causes potentially from evaluated: cardiovascular kidney diseases infections. Results The infection disease. Most died 19 50 age. Deaths disease proportionally higher than general population progressive decrease during...
Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. rheumatoid arthritis (RA) are at a high risk of severe outcomes, especially those under immunosuppression or associated comorbidities. However, few studies assessed safety vaccine in patients RA. Objective To evaluate vaccines against SARS-CoV-2 Methods This data from study “Safety and Efficacy on Vaccine Rheumatic Diseases,”...
Breakthrough COVID-19 (occurring in fully vaccinated people) has been described. Data on its characteristics among immune mediated rheumatic disesases (IMRD) patients are scarce. This study describes breakthrough IMRD participating of SAFER-study, a Brazilian multicentric cohort evaluating safety, effectiveness and immunogenicity SARS-Cov-2 vaccines autoimmune diseases. Descriptive analysis binary logistic regression model, to evaluate predictors COVID-19-related hospitalization, were...
Breakthrough COVID-19 (occurring in fully vaccinated people) has been described. Data on its characteristics among immune-mediated rheumatic disease (IMRD) patients are scarce. This study describes breakthrough occurring IMRD participating the SAFER-study, a Brazilian multicentric cohort evaluating safety, effectiveness, and immunogenicity of SARS-CoV-2 vaccines with autoimmune diseases. A descriptive analysis population binary logistic regression model were performed to evaluate predictors...
Introduction: After more than 20 years of sustained work, the Latin American Group for Study Lupus (GLADEL) has made a significant number contributions to field lupus, not only in differential role that race/ethnicity plays its course and outcome but also several other studies including beneficial effects using antimalarials lupus patients development consensus guidelines treatment our region. Methods: A new generation “Lupus Investigators” 40 centers throughout America been constituted...
The Latin American population living with lupus lacks reliable and culturally competent health education resources. We describe a Spanish Portuguese online program to educate people about lupus.An extensive network of stakeholders participated in the design, implementation, dissemination, evaluation. Patients rheumatologists selected core topics. Rheumatologists prepared content using evidence-based data. Adaptations were conducted meet audience's literacy cultural values. Social media was...
To compare the correlations of histological class inferences based on clinical manifestations and laboratory tests between rheumatologists nephrologists, to determine associations data with classes develop an instrument that can assist identification in lupus nephritis (LN).Retrospective study medical records 80 systemic erythematosus patients (SLICC criteria classification, 2012) who underwent kidney biopsy 2010 2017. Two two nephrologists received answered questions regarding which was...
COVID-19, caused by the virus SARS-CoV-2, has brought extensive challenges to scientific community in recent months. Several studies have been undertaken an attempt minimize impact of disease worldwide. Although new knowledge quickly disseminated, including viral mechanisms, pathophysiology, and clinical findings, there is a lack information on effective pharmacological management this disease. In vitro shown some benefits related use antimalarials (chloroquine hydroxychloroquine) for...
Myostatin is a protein in the TGF-β family that negatively regulates muscle mass, and follistatin myostatin antagonist.The aim of this study was to measure serum levels idiopathic inflammatory myopathy patients correlate these with strength, fatigue, functional capacity, damage, enzymes.This multicenter cross-sectional including 50 (34 dermatomyositis 16 polymyositis [PM]) 52 healthy individuals (control group [CG]). The disease status evaluated according International Myositis Assessment &...
Abstract Background Patients using immunosuppressive drugs may have unfavorable results after infections. However, there is a lack of information regarding COVID-19 in these patients, especially patients with rheumatoid arthritis (RA). Therefore, the aim this study was to evaluate risk factors associated hospitalizations RA. Methods This multicenter, prospective cohort within ReumaCoV Brazil registry and included 489 In context, 269 who tested positive for were compared 220 negative (control...
To describe characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with rheumatic immune-mediated inflammatory diseases (IMIDs) from Argentina, Mexico and Brazil, to assess factors associated mortality this population.Data 3 national registries, SAR-COVID (Argentina), CMR-COVID (Mexico), ReumaCoV-Brasil (Brazil), were combined. Adult IMIDs SARS-CoV-2 recruited. Sociodemographic data, comorbidities, IMID clinical treatment, presentation outcomes...
Abstract Objectives To compare the impact of COVID-19 on clinical status and psychological condition in patients with immune-mediated rheumatic diseases (IMRD) infected by SARS-CoV-2 IMRD controls not infected, during a 6-month follow-up. Methods The ReumaCoV Brasil is longitudinal study designed to follow-up for 6 months after (cases) compared no (controls). Clinical data, disease activity measurements current treatment regarding IMRD, outcomes were evaluated all patients. Disease was...