A5043685914- Cannabis and Cannabinoid Research
- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Inflammatory Bowel Disease
- Immune Cell Function and Interaction
- Neurogenesis and neuroplasticity mechanisms
- Liver Disease Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Gut microbiota and health
- Phosphodiesterase function and regulation
- Hepatitis B Virus Studies
- Microscopic Colitis
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Clostridium difficile and Clostridium perfringens research
- Hepatitis C virus research
- Sleep and Wakefulness Research
- Cholinesterase and Neurodegenerative Diseases
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Alcohol Consumption and Health Effects
Universidade de Santiago de Compostela
2021-2025
Garrahan Hospital
2024
Instituto Cajal
2013-2022
Instituto de Investigación Sanitaria de Santiago
2022
Complejo Hospitalario Universitario de Santiago
2015-2022
Spanish Multiple Sclerosis Network
2014-2021
ORCID
2020-2021
Instituto de Salud Carlos III
2012-2021
Hospital Universitario Reina Sofía
2018
Centro de Biología Molecular Severo Ochoa
2014
Inflammation in the central nervous system (CNS) is a complex process that involves multitude of molecules and effectors, it requires transmigration blood leukocytes across blood-brain barrier (BBB) activation resident immune cells. Cannabidiol (CBD), non-psychotropic cannabinoid constituent Cannabis sativa, has potent anti-inflammatory immunosuppressive properties. Yet, how this compound modifies deleterious effects inflammation TMEV-induced demyelinating disease (TMEV-IDD) remains unknown....
Abstract The endocannabinoid system exhibits anti‐inflammatory properties by regulating cytokine production. Anandamide (AEA) down‐regulates proinflammatory cytokines in a viral model of multiple sclerosis (MS). However, little is known about the mechanisms which AEA exerts these effects. Microglial cells are main source within brain and first barrier defense against pathogens acting as antigen presenting cells. IL‐10 key physiological negative regulator microglial activation. In this study...
Cannabidiol (CBD) is the most abundant cannabinoid in Cannabis sativa that has no psychoactive properties. CBD been approved to treat inflammation, pain and spasticity associated with multiple sclerosis (MS), of which demyelination oligodendrocyte loss are hallmarks. Thus, we investigated protective effects against damage progenitor cells (OPCs) mediated by immune system. Doses 1 μM protect OPCs from oxidative stress decreasing production reactive oxygen species. also protects apoptosis...
Abstract The endocannabinoid anandamide (AEA) is released by macrophages and microglia on pathological neuroinflammatory conditions such as multiple sclerosis (MS). CD200 a membrane glycoprotein expressed in neurons that suppresses immune activity via its receptor (CD200R) mainly located macrophages/microglia. CD200‐CD200R interactions contribute to the brain privileged status. In this study, we show AEA protects from microglia‐induced neurotoxicity interaction. increases expression of...
Abstract Theiler's virus infection of the central nervous system (CNS) induces an immune‐mediated demyelinating disease in susceptible mouse strains and serves as a relevant model for human multiple sclerosis (MS). Cannabinoids have been shown to exert beneficial effects on animal models MS evidence suggests that endocannabinoid plays role tonic control spasticity. In this study we show OMDM1 [( R )‐ N ‐oleoyl‐(1′‐hydroxybenzyl)‐2′‐ethanolamine] OMDM2 S...
Cannabinoid (CB) receptor agonists have potential utility as anti‐inflammatory drugs for the treatment of many disease conditions. In present study, we investigated effects synthetic CB 2 ligand, JWH‐133 on production interleukins (ILs), IL‐12 and IL‐10 by lipopolyssacharide (LPS) or Theiler's virus (TMEV)‐activated macrophages. evoked a concentration‐related inhibition (10 n M –5 μ ) LPS/IFN‐γ induced IL‐12p40 release. The effect (100 was significantly blocked antagonist SR‐144528 (1 )....
Cannabinoids have recently been approved as a treatment for pain in multiple sclerosis (MS). Increasing evidence from animal studies suggests that this class of compounds could also prove efficient to fight neurodegeneration, demyelination, inflammation and autoimmune processes occurring pathology. However, the use cannabinoids is limited by their psychoactive effects. In context, potentiation endogenous cannabinoid signalling represent substitute exogenously administrated ligands. Here, we...
The failure to undergo remyelination is a critical impediment recovery in multiple sclerosis. Chondroitin sulfate proteoglycans (CSPGs) accumulate at demyelinating lesions creating nonpermissive environment that impairs axon regeneration and remyelination. Here, we reveal new role for 2-arachidonoylglycerol (2-AG), the major CNS endocannabinoid, modulation of CSPGs deposition progressive model sclerosis, Theiler9s murine encephalomyelitis virus-induced disease. Treatment with potent...
Multiple sclerosis (MS) is characterized by a combination of inflammatory and neurodegenerative processes variously dominant in different stages the disease. Thus, immunosuppression goal standard for stage, novel remyelination therapies are pursued to restore lost function. Cannabinoids such as 9Δ-THC CBD multi-target compounds already introduced clinical practice multiple (MS). Semisynthetic cannabinoids designed improve bioactivities druggability their natural precursors. VCE-004.8, an...
Abstract The innate immune response is mediated by primary modulators such as cytokines and chemokines that together with cells resident glia orchestrate CNS immunity inflammation. Growing evidence supports the endocannabinoid 2‐arachidonoylglycerol (2‐AG) exerts protective actions in injury models. Here, we used acute phase of Theiler's virus induced demyelination disease (TMEV‐IDD) a model neuroinflammation to investigate whether 2‐AG modifies brain responses TMEV leukocyte trafficking. or...
Abstract Background VCAM-1 represents one of the most important adhesion molecule involved in transmigration blood leukocytes across blood-brain barrier (BBB) that is an essential step pathogenesis MS. Several evidences have suggested potential therapeutic value cannabinoids (CBs) treatment MS and their experimental models. However, effects endocannabinoids on regulation are poorly understood. In present study we investigated anandamide (AEA) expression induced by Theiler's virus (TMEV)...
Recent studies have begun to point out the contribution of microbiota multiple sclerosis (MS) pathogenesis. Theiler's murine encephalomyelitis virus induced demyelinating disease (TMEV-IDD) is a model progressive MS. Here, we first analyze effect intracerebral infection with TMEV on commensal and secondly, whether early depletion influences immune responses acute phase (14 dpi) its impact chronic (85 dpi). The intracranial inoculation was associated moderate dysbiosis. oral administration...
Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut may affect disease course. Using a well-established model of progressive triggered by intracranial infection with Theiler's murine encephalomyelitis virus (TMEV), we sought to determine whether induced oral antibiotics (ABX) administered on presymptomatic symptomatic phases influences its We also addressed effects recolonization after ABX withdrawn presence or...
Previous studies in experimental autoimmune encephalomyelitis (EAE) models have shown that some probiotic bacteria beneficially impact the development of this disease. Here, we tested therapeutic effect two commercial multispecies probiotics—Lactibiane iki and Vivomixx—on clinical outcome established EAE. Lactibiane improves EAE a dose-dependent manner decreases central nervous system (CNS) demyelination inflammation. This improvement is related to inhibition pro-inflammatory stimulation...