Mercedes García
A5059644868- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Vasculitis and related conditions
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Renal Diseases and Glomerulopathies
- Inflammatory Myopathies and Dermatomyositis
- Peripheral Neuropathies and Disorders
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Platelet Disorders and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Immunodeficiency and Autoimmune Disorders
- Otitis Media and Relapsing Polychondritis
- Cytokine Signaling Pathways and Interactions
- Urticaria and Related Conditions
- Lymphoma Diagnosis and Treatment
- Medical research and treatments
- Spondyloarthritis Studies and Treatments
- Blood disorders and treatments
- Celiac Disease Research and Management
- Ocular Diseases and Behçet’s Syndrome
Universidad Autónoma de Madrid
2025
Hospital Universitario Infanta Leonor
2023-2025
Willows Veterinary Centre and Referral Service
2025
Hospital Italiano La Plata
2015-2024
National University of General San Martín
2015-2024
Hospital Privado
2014-2022
Mayo Clinic in Arizona
2022
Digital Research Alliance of Canada
2021
Psoriasis Association
2021
Vall d'Hebron Institut de Recerca
2021
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals European (EA), African (AA) Hispanic Amerindian (HA) ancestry. identify 58 distinct non-HLA regions in EA, 9 AA 16 HA (∼50% these have multiple independent associations); include 24 novel (P<5 × 10-8), refined signals established regions, extended associations to additional...
Autism is a severe neurodevelopmental disorder defined by social and communication deficits ritualistic-repetitive behaviors that are detectable in early childhood. The etiology of idiopathic autism strongly genetic, oligogenic transmission likely. first stage two-stage genomic screen for was carried out the Collaborative Linkage Study on individuals affected with from 75 families ascertained through an sib-pair. strongest multipoint results were regions chromosomes 13 7. highest maximum...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with strong genetic component. We undertook the present work to perform first genome-wide association study on individuals from Americas who are enriched for Native American heritage.We analyzed 3,710 US and 4 countries of Latin America were diagnosed as having SLE, healthy controls. Samples genotyped HumanOmni1 BeadChip. Data out-of-study controls HumanOmni2.5 also included. Statistical analyses performed using SNPtest...
Systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune disease, represents significant challenge for both diagnosis treatment. Patients with SLE in Latin America face special problems that should be considered when therapeutic guidelines are developed. The objective of the study is to develop clinical practice American patients lupus. Two independent teams (rheumatologists experience management methodologists) had an initial meeting Panama City, Panama, April 2016. They...
The objective of the study was to evaluate influence male gender in clinical presentation and outcome systemic lupus erythematosus a prospective inception cohort Latin-American patients. Of 1214 SLE patients included GLADEL cohort, 123 were male. Demographic characteristics as well manifestations, laboratory profile, activity damage scores evaluated at onset during course disease compared with female median age 27 that diagnosis 29.2 years. Delay shorter males (134 versus 185 days, P =...
Aim The aim of this study was to identify factors predictive serious infections over time in patients with systemic lupus erythematosus (SLE). Methods A multi-ethnic, multi-national Latin American SLE cohort studied. Serious infection defined as one that required hospitalization, occurred during a hospitalization or led death. Potential predictors included were sociodemographic factors, clinical manifestations (per organ involved, lymphopenia and leukopenia, independently) previous at...
To assess whether genetically determined Amerindian ancestry predicts increased presence of risk alleles known susceptibility genes for systemic lupus erythematosus (SLE).
The objective was to determine the prevalence of metabolic syndrome (MS) in patients with systemic lupus erythematosus (SLE) Argentina, assess factors associated it, and compare results a control group non-inflammatory disorders. study included 147 SLE 119 controls. MS defined according criteria by American Heart Association/National Heart, Lung, Blood Institute (AHA/NHLBI) Scientific Statement. Demographic characteristics, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)...
The real-world effectiveness of belimumab for systemic lupus erythematosus (SLE) in six countries was evaluated the OBSErve program. aim this post hoc analysis (GSK study 206351) to pool individual patient data further evaluate a large sample patients with SLE. (Argentina, Canada, Germany, Spain, Switzerland, and USA) enrolled adults ≥ 18 years age SLE, who were prescribed as part standard therapy (index: date initiation). Endpoints (month 6 vs. index) included physician-assessed overall...
Abstract Argentine population genetic structure was examined using a set of 78 ancestry informative markers (AIMs) to assess the contributions European, Amerindian, and African in 94 individuals members this population. Using Bayesian clustering algorithm STRUCTURE, mean European contribution 78%, Amerindian 19.4%, 2.5%. Similar results were found weighted least square method: 80.2%; 18.1%; African, 1.7%. Consistent with previous studies current showed very few (four 94) greater than 10%...
Objectives To assess the incidence and clinical findings associated with presence of ammonium urate urolithiasis in dogs congenital portosystemic shunts. Materials Methods A retrospective review diagnosed extrahepatic shunts or intrahepatic 15 referral hospitals between 2010 2023. Data including signalment, signs, physical examination clinicopathologic test results at time diagnosis were collected, was recorded. Results total 363 included. The overall 19.3%. Dogs more likely to have compared...
Background: Albinism is a genetic condition marked by lack of melanin in the skin, hair, and eyes, leading to increased sensitivity light susceptibility skin cancer. Oculocutaneous albinism buffaloes caused G>A mutation tyrosinase gene, which introduces premature stop codon, rendering enzyme inactive. Despite efforts prevent defects, persists because it an autosomal recessive trait. This study used capillary sequencing analyze gene local buffaloes. Methods: One hundred forty-eight (148)...
IntroductionAdmissions are frequent in SLE patients and the main causes activity of disease infections.ObjectiveTo analyze frequency hospitalizations as well its associated factors.MethodsCross sectional study included RELESSAR registry. Sociodemographic data, autoantibodies, manifestations treatments received at moment admission were collected. The sample was divided two groups according to present or not hospitalization. Number, factors hospitalization described.ResultsA total 1515 adult...
The aim of this study was to assess the cumulative incidence, risk and protective factors impact on mortality primary cardiac disease in SLE patients (disease duration ≤2 years) from a multi-ethnic, international, longitudinal inception cohort (34 centres, 9 Latin American countries).Risk (pericarditis, myocarditis, endocarditis, arrhythmias and/or valvular abnormalities) were evaluated.Of 1437 patients, 202 (14.1%) developed one or more manifestations: 164 pericarditis, 35 valvulopathy, 23...
Anti-double stranded desoxyribonucleic acid (anti-dsDNA) antibodies are considered fairly specific for systemic lupus erythematosus (SLE) and their quantification is useful the clinical management of SLE patients. We assessed diagnostic performance QUANTA Flash dsDNA chemiluminescent immunoassay (CIA) in comparison to an ELISA, using patients from five participating countries. The main focus was evaluate correlation between anti-dsDNA antibody results CIA global disease activity, as measured...
Ultrasound has demonstrated to be a highly sensitive tool in the evaluation of entheses spondyloarthropathy (SpA) patients and improves ability clinical examination detect enthesopathy.The objectives study were determine prevalence subclinical enthesopathy SpA evaluate reliability ultrasound detection abnormal findings indicative enthesopathy.Six hundred lower-limb assessed 60 without known history entheseal involvement. Sixty rheumatoid arthritis 30 control subjects included as groups....
Aim A decrease in proteinuria has been considered protective from renal damage lupus nephritis (LN), but a cut-off point yet to be established. The aim of this study was identify the predictors patients with LN and determine best for proteinuria. Methods We included defined clinically or histologically. Possible at time diagnosis were examined: proteinuria, low complement, anti-double-stranded DNA antibodies, red cell casts, creatinine level, hypertension, activity (assessed by Systemic...
Purpose The purpose of this paper is to determine the factors predictive flares in systemic lupus erythematosus (SLE) patients. Methods A case-control study nested within Grupo Latino Americano De Estudio de Lupus (GLADEL) cohort was conducted. Flare defined as an increase ≥4 points SLEDAI. Cases were patients with at least one flare. Controls selected by matching cases length follow-up. Demographic and clinical manifestations systematically recorded a common protocol. Glucocorticoid use...
To describe clinical effectiveness of belimumab for systemic lupus erythematosus (SLE) in real-world practice Argentina.This retrospective, observational study analysed medical record data patients with SLE treated 15 centres Argentina. Primary endpoint: overall response (assessed on a scale similar to the 6-point Physician Global Assessment) at months 6, 12, 18 and 24, all versus index (belimumab initiation). Secondary endpoints: improvement disease activity (SELENA-SLEDAI), manifestations,...
Background Systemic lupus erythematosus (SLE) often mimics symptoms of other diseases, and the interval between symptom onset diagnosis may be long in some these patients. Aims: To describe characteristics associated with time to SLE its impact on damage accrual mortality patients from a Latin American inception cohort. Methods Patients were multi-ethnic, multi-national Latin-American All participating centers had specialized clinics. Socio-demographic, clinical/laboratory, disease activity,...