Ketty Lysie Libardi Lira Machado
A5025754771- SARS-CoV-2 and COVID-19 Research
- Salivary Gland Disorders and Functions
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Systemic Sclerosis and Related Diseases
- Ocular Diseases and Behçet’s Syndrome
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Autoimmune and Inflammatory Disorders Research
- Vaccine Coverage and Hesitancy
- Peripheral Neuropathies and Disorders
- Inflammasome and immune disorders
- Otitis Media and Relapsing Polychondritis
- Retinal and Optic Conditions
- Nutrition and Health in Aging
- Education during COVID-19 pandemic
- Dermatological and COVID-19 studies
- Healthcare Regulation
- Inflammatory Myopathies and Dermatomyositis
- Heparin-Induced Thrombocytopenia and Thrombosis
- Long-Term Effects of COVID-19
- Skin Diseases and Diabetes
- Mosquito-borne diseases and control
- Psychosomatic Disorders and Their Treatments
- Chronic Lymphocytic Leukemia Research
Universidade Federal do Espírito Santo
2017-2025
Universidade de São Paulo
2017-2022
Hospital das Clínicas da Universidade Federal de Minas Gerais
2022
Hospital das Clínicas da Universidade Federal de Pernambuco
2022
Hospital Moinhos de Vento
2022
Pontifícia Universidade Católica do Rio Grande do Sul
2022
Universidade Federal do Amazonas
2022
Universidade Federal de São Paulo
2022
Universidade Federal Fluminense
2022
Universidade Federal de Juiz de Fora
2022
Objective: To evaluate the humoral response to and impact of SARS-CoV-2 vaccination in patients with systemic lupus erythematosus a multicenter cohort design. Methods: Data for this analysis were obtained from Study Safety, Effectiveness Duration Immunity after Vaccination against Patients Immune-Mediated Inflammatory Diseases (SAFER), prospective, multicenter, phase IV, real-world study conducted across different regions Brazil June/2021 March/2024. aged >18 years (SLE) who received any...
Introdução: Fungos do gênero Exophiala sp são encontrados no solo e na matéria orgânica. Eles têm baixa virulência geralmente sintomáticos em indivíduos imunossuprimidos. As principais manifestações clínicas alterações cutâneas ou subcutâneas, sendo raro o acometimento articular. Relato de caso: Relata-se um caso paciente com Lúpus Eritematoso Sistêmico (LES), uso terapia imunossupressora, apresentando quadro monoartrite crônica punho esquerdo, diagnóstico artrite séptica causada por fungo...
Yellow Fever (YF) vaccination is suggested to induce a large number of adverse events (AE) and suboptimal responses in patients with autoimmune diseases (AID); however, there have been no studies on 17DD-YF primary performance AID. This prospective non-interventional study conducted between March July, 2017 assessed the safety immunogenicity planned Adult AID (both sexes) were enrolled, along healthy controls (HC), at single hospital (Vitória, Brazil). Included referred for by...
To provide guidelines on the coronavirus disease 2019 (COVID-19) vaccination in patients with immune-mediated rheumatic diseases (IMRD) to rheumatologists considering specific scenarios of daily practice based shared-making decision (SMD) process.
Abstract Background Diagnosis of SS is a complex task, as no symptom or test unique to this syndrome. The American-European Consensus Group (AECG 2002) and the classification criteria 2016 (ACR/EULAR 2016) emerged through search for consensus. This study aims assess prevalence Sjögren’s Syndrome (SS) in patients with Systemic Lupus Erythematosus (SLE), according AECG 2002 ACR-EULAR classifications, well clinical histopathological features overlap. To date, there that has evaluated SLE, using...
The present study aimed at investigating whether the hydroxychloroquine (HCQ) treatment would impact neutralizing antibody production, viremia levels and kinetics of serum soluble mediators upon planned 17DD-Yellow Fever (YF) primovaccination (Bio-Manguinhos-FIOCRUZ) primary Sjögren's syndrome (pSS). A total 34 pSS patients 23 healthy controls (HC) were enrolled. group was further categorized according to use HCQ (HCQ Non-HCQ). YF-plaque reduction neutralization test (PRNT ≥1:50), YF...
Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. rheumatoid arthritis (RA) are at a high risk of severe outcomes, especially those under immunosuppression or associated comorbidities. However, few studies assessed safety vaccine in patients RA. Objective To evaluate vaccines against SARS-CoV-2 Methods This data from study “Safety and Efficacy on Vaccine Rheumatic Diseases,”...
Breakthrough COVID-19 (occurring in fully vaccinated people) has been described. Data on its characteristics among immune mediated rheumatic disesases (IMRD) patients are scarce. This study describes breakthrough IMRD participating of SAFER-study, a Brazilian multicentric cohort evaluating safety, effectiveness and immunogenicity SARS-Cov-2 vaccines autoimmune diseases. Descriptive analysis binary logistic regression model, to evaluate predictors COVID-19-related hospitalization, were...
Breakthrough COVID-19 (occurring in fully vaccinated people) has been described. Data on its characteristics among immune-mediated rheumatic disease (IMRD) patients are scarce. This study describes breakthrough occurring IMRD participating the SAFER-study, a Brazilian multicentric cohort evaluating safety, effectiveness, and immunogenicity of SARS-CoV-2 vaccines with autoimmune diseases. A descriptive analysis population binary logistic regression model were performed to evaluate predictors...
Dentre as vacinas contra a COVID-19 aprovadas pela ANVISA e incorporadas ao Programa Nacional de Imunização (PNI) destacam-se vacina vírus inativado CoronaVac (Sinovac/Butantan), ChAdOx1 (AstraZeneca/Fiocruz) em plataforma com vetor viral. Diferentes mecanismos ação resultam diferentes reações adversas imunizante. O objetivo deste trabalho é avaliar frequência gravidade dos eventos adversos relacionados às (VAC) AstraZeneca (AZV) uma coorte trabalhadores da saúde. Estudo longitudinal...
Abstract The present study aimed to investigate whether the serum biomarkers of immune response orchestrate seroconversion status in patients with autoimmune diseases (AID) upon planned primary 17DD-YF vaccination. For this purpose a total 161 individuals were enrolled prospective study, including Rheumatoid Arthritis (RA = 38), Spondyloarthritis (SpA 51), Systemic Lupus Erythematosus (SLE 21) and Sjögren’s Syndrome (SS 30) along group healthy controls (HC 21). Analysis plaque reduction...
Chikungunya is an arboviral disease caused by a virus with wide geographical distribution in endemic areas. This case report documents patient antisynthetase syndrome post-chikungunya infection. Autoimmune diseases result from breakdown of immune tolerance. Among all triggers, viruses represent the greatest environmental potential to precipitate inflammatory myopathy.
With emergent Sars-Cov-2, a highly transmissive virus that caused millions of deaths worldwide, the development vaccines became urgent to combat COVID-19.Although rare, important adverse effects had been described in hypothetical scenario immune system overstimulation or overreaction.Still's disease is rare inflammatory syndrome unknown etiology.It manifests as cytokine storm, mainly IL-18 and IL-1β, presents itself with fever spikes, joint pain, maculopapular evanescent salmon-pink skin...
Introdução: A Fibromialgia (FM) é uma síndrome crônica associada a fadiga, distúrbios do sono, humor, cognitivos e dor musculoesquelética generalizada. Objetivos: Avaliar o perfil clínico de pacientes com FM, os tratamentos mais utilizados impacto por meio escalas específicas. Métodos: Estudo descritivo base em dados Projeto Epifibro 2.0 atendidos ambulatório um Serviço Reumatologia, que preencheram Critérios Diagnóstico Colégio Americano Reumatologia 2010 para FM. coleta dos foi realizada...
Introduction: Behçet’s disease is a chronic, multisystemic, inflammatory syndrome characterized by recurrent attacks of oral and genital ulcers, in addition to cutaneous, ophthalmic, central nervous system, gastrointestinal vascular involvement. Other manifestations may occur more rarely, such as pulmonary artery aneurysm thrombosis. Case report: We report case woman presenting with dyspnea hemoptysis secondary aneurysms thrombosis caused the first clinical manifestations. Conclusion:...
Objective: To evaluate the humoral response to and effectiveness of SARS-CoV-2 vaccination in patients with systemic lupus erythematosus a multicenter cohort design. Methods: Data for this analysis were obtained from Study Safety, Effectiveness Duration Immunity after Vaccination against Patients Immune-Mediated Inflammatory Diseases (SAFER), prospective, multicenter, phase IV, real-world study conducted across different regions Brazil. aged >18 years (SLE) who received any one...
Background/Objectives: The effectiveness of COVID-19 vaccine in patients with immune-mediated inflammatory diseases (IMID) depends on the underlying disease, immunosuppression degree and regimens. We evaluate safety immunogenicity different schedules. Methods: SAFER study: “Safety Vaccine Rheumatic Disease”, is a Brazilian multicentric prospective observational phase IV study real-life. Data were analyzed after 2 or 3 doses vaccines: adenoviral vectored (ChAdOx1 nCoV-19, Astrazeneca), mRNA...