A5055913555- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Inflammatory mediators and NSAID effects
- Salivary Gland Disorders and Functions
- Cancer Immunotherapy and Biomarkers
- Blood properties and coagulation
- Protein Degradation and Inhibitors
- Eicosanoids and Hypertension Pharmacology
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Systemic Sclerosis and Related Diseases
- Acute Myeloid Leukemia Research
- Protein Kinase Regulation and GTPase Signaling
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Peroxisome Proliferator-Activated Receptors
- Chronic Lymphocytic Leukemia Research
- Cardiovascular Conditions and Treatments
- Renal cell carcinoma treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Synthesis and biological activity
University of Siena
2025
University of Udine
2021-2024
Eli Lilly (United States)
2021-2023
Universitat de Barcelona
2023
Hospital Clínic de Barcelona
2023
Hospital de Clínicas
2023
Hospital Maciel
2023
Universidad de la República
2023
Hospital Universitario Infanta Leonor
2023
Ospedale Santa Maria della Misericordia di Udine
2023
What baseline predictors would be involved in mortality people with primary Sjögren syndrome (SjS) remains uncertain. This study aimed to investigate the characteristics collected at time of diagnosis SjS associated and identify risk factors for all-cause death deaths related systemic activity measured by ESSDAI score.In this international, real-world, retrospective, cohort study, we retrospectively data from 27 countries on causes Big Data Registry. Inclusion criteria consisted fulfilling...
Abstract Background Mitral regurgitation (MR) is the second most common valvular heart disease (VHD) in Europe, for which resolutive treatment surgical intervention. A careful preoperative evaluation of patients with MR important to optimize timing intervention and avoid possible complication after surgery. For this purpose, finding reliable prognostic markers predict adverse outcome mitral valve surgery may be fundamental. The aim study was assess parameters, among basic speckle tracking...
TP53 co-mutations have shown association with poor prognosis in various solid tumors. For EGFR-mutated advanced non-small cell lung cancer (aNSCLC), conflicting results exist regarding its impact on survival. Clinical outcomes and genomic data were obtained retrospectively from the real-world (rw) de-identified clinicogenomic database. Patients who initiated therapy for aNSCLC between January 2014 December 2020 identified. evaluated by TP53-mutational status. In 356 eligible patients (median...
Parotid swelling (PSW) is a major predictor of non-Hodgkin's lymphoma (NHL) in primary SS (pSS). However, since detailed information on the time onset and duration PSW scarce, this was investigated to verify whether it may lead further improved prediction. NHL localization concomitantly studied evaluate role parotid gland microenvironment pSS-related lymphomagenesis.A multicentre study conducted among patients with pSS who developed B cell during follow-up matched controls that did not...
Abstract Dysregulation of enzymes involved in prostaglandin biosynthesis plays a critical role influencing the biological behavior and clinical outcome several tumors. In human gliomas, overexpression cyclooxygenase-2 has been linked to increased aggressiveness poor prognosis. contrast, E synthase gliomas not established. We report that constitutive expression microsomal synthase-1 (mPGES-1) is associated with E2 (PGE2) production stimulation growth astroglioma cell line U87-MG compared...
ObjectivesThis post hoc analysis assessed the safety of pemetrexed and platinum in combination with pembrolizumab, including time-to-onset time-to-resolution all-cause any-grade grade ≥3 adverse events (AEs) renal AEs.Materials MethodsPatient-level data from KEYNOTE-189 were analyzed all-subjects-as-treated population (pembrolizumab arm, n = 405; placebo 202), among patients who received ≥5 cycles (pemetrexed/pembrolizumab/platinum 310; pemetrexed/placebo/platinum 135). All-cause AEs...
The distribution of endothelin-converting enzyme-1 (ECE-1) mRNA and protein was investigated in human kidney excised because renal tumors. ECE-1 immunoreactivity detected by immunohistochemistry throughout the different areas vascular tubular structures. In cortex, immunostaining present endothelial surface arcuate interlobular arteries arterioles. Weak specific over some proximal distal tubules. Few glomerular cells contained protein. medulla, observed vasa recta bundles capillaries. also...
The mechanisms involved in storage-induced damage platelets are not well understood, but membrane signalling via Ca2+ ion flux may affect mitochondrial H+ gradients and metabolism the intrinsic pathways of cell death, platelet survival function. In this study, effects blood bank storage conditions, including reduced plasma concentration interrupted agitation, were evaluated from 136 healthy donors. Mitochondrial potential (DeltaPsim), an indicator its sensitivity to ionophore A23187,...
Receptor and nonreceptor protein tyrosine kinases (PTKs) play a key role in the control of normal neoplastic cell growth. The availability PTK inhibitors prompted us to evaluate effects genistein, natural inhibitor PTKs, on vitro colony formation by multilineage colony‐forming units (CFU‐Mix), erythroid bursts (BFU‐E), granulocyte‐macrophage (CFU‐GM), long‐term culture‐initiating cells (LTC‐IC) acute myelogenous leukaemia (CFU‐AML). Continuous exposure marrow blood mononuclear non‐adherent...
7610 Background: A subset of lung adenocarcinomas harbors a small inversion within chromosome 2p, giving rise to transforming fusion gene EML4-ALK (ALK) which encodes an activated tyrosine kinase. To help identification this the NSCLC population South Italy, we retrospectively examined its incidence in cohort adenocarcinomas, clinical characteristics and treatment outcomes pts who had rearranged ALK. Methods: Ninety-six adenocarcinoma pts. (58 male, 38 female, median age 64 years), received...