A5052637906- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Retinopathy of Prematurity Studies
- Ocular Diseases and Behçet’s Syndrome
- Corneal surgery and disorders
- Marriage and Sexual Relationships
- Ocular Infections and Treatments
- Ocular Oncology and Treatments
- Corneal Surgery and Treatments
- Ophthalmology and Visual Impairment Studies
- Traumatic Ocular and Foreign Body Injuries
- CNS Lymphoma Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Neural dynamics and brain function
- Vascular Malformations Diagnosis and Treatment
- Ocular Surface and Contact Lens
- Ocular and Laser Science Research
- Photoreceptor and optogenetics research
- Acute Ischemic Stroke Management
- Lymphoma Diagnosis and Treatment
Mayo Clinic
2017-2024
University of Minnesota Rochester
2022-2024
Mayo Clinic in Arizona
2017-2024
University of California, San Francisco
2021-2024
WinnMed
2019-2024
Lehigh Valley Hospital-Pocono
2024
Lehigh Valley Health Network
2024
Spectral Labs (United States)
2022-2024
Ophthalmology Associates (United States)
2005-2023
University of Minnesota
2004-2022
the National Institutes of Health (NIH) in Bethesda, Maryland.The conference provided an opportunity to gather a diverse group more than 200 experts from both academic ophthalmology and ophthalmic pharmaceutical industry, including laboratory researchers clinicians, discuss recent advances delivery systems that convey ocular drugs posterior segment how these might be successfully used commercial products.The two-day meeting comprised following nine sessions: (1) eye anatomy barriers drug...
Increasing evidence suggests a central role for mitochondrial (mt) dysfunction in age-related macular degeneration (AMD). Previous proteomic data from the retinal pigment epithelium (RPE) revealed significant changes to mt proteins, suggesting potential functional defects and damage DNA (mtDNA) with AMD progression. The present study tests hypothesis that mtDNA increases aging AMD.Genomic was isolated region of human donor RPE graded stages (Minnesota Grading System [MGS] 1-4)....
Macrophages can be polarized to exhibit either pro‐inflammatory M1 or pro‐angiogenic M2 phenotypes, but have high phenotypic plasticity. This pilot study investigated macrophage polarization in the macular retina and choroid of age‐related degeneration (AMD) non‐AMD subjects, as well AMD choroidal neovascular membranes (CNVM). All specimens were evaluated for routine histopathology. Quantitative real‐time polymerase chain reaction representative ( CXCL11 ) CCL22 transcripts performed on...
The incidence of cystic fibrosis-related diabetes (CFRD) and the prevalence diabetic microvascular complications were determined at University Minnesota.Cystic fibrosis patients have undergone annual oral glucose tolerance testing since 1990. Database review was performed to determine duration results urine albumin-to-creatinine ratio (U(alb:Cr)) screening dilated retinal exams. In addition, 59 individuals underwent detailed retinopathy, nephropathy, neuropathy, gastroenteropathy...
Age-related macular degeneration (AMD) is the leading cause of vision loss in individuals over age 65. Histopathological changes become evident retinal pigment epithelium (RPE), a monolayer that provides metabolic support for overlying photoreceptors, even at earliest stages AMD precede loss. In previous global RPE proteome analysis, were identified content several mitochondrial proteins associated with AMD. this study, subproteome mitochondria isolated from human donor graded Minnesota...
ObjectiveTo assess the quality, empathy, and safety of expert edited large language model (LLM), human created LLM responses to common retina patient questionsDesignRandomized, masked multicenter studyParticipantsTwenty-one questions were randomly assigned among 13 specialists. Each a response (Expert) then (ChatGPT-4)-generated that question (Expert+AI), timing themselves for both tasks. Five LLMs (ChatGPT-3.5, ChatGPT-4, Claude 2, Bing, Bard) also generated each question. The original...
ObjectiveTo determine the appropriateness of ophthalmology recommendations from an online chat-based artificial intelligence model to questions.Patients and MethodsCross-sectional qualitative study April 1, 2023, 30, 2023. A total 192 questions were generated spanning all ophthalmic subspecialties. Each question was posed a large language (LLM) 3 times. The responses graded by appropriate subspecialists as appropriate, inappropriate, or unreliable in 2 grading contexts. first context if...
Topical cyclosporin A was used in the management of 43 patients with a variety anterior segment inflammatory disorders that had failed corticosteroid treatment. Treatment topical ranged from 1 week to months, mean treatment period 13 months. Thirty-five (81%) including high-risk keratoplasty, atopic and vernal keratoconjunctivitis, ligneous conjunctivitis, ulcerative keratitis, Mooren's ulcer beneficial result, resolution, reduction, or prevention inflammation. Six (14%) scleritis, ocular...
Age-related macular degeneration (AMD) is characterized clinically by changes in the retinal pigment epithelium (RPE), formation of drusen between RPE and underlying vasculature, geographic atrophy, choroidal neovascularization. Later clinical stages are accompanied impaired central vision. A limited understanding molecular events responsible for AMD has constrained development effective treatments. proteomics approach was used to investigate mechanisms identify proteins exhibiting...
To compare the pharmacokinetics and tissue response between intravitreal microcannulation injections into suprachoroidal space using bevacizumab.Sixty-two pigs were studied. Either a pars plana bevacizumab or viscoelastic-enhanced microcannula injection was performed with either 1.25 mg (group 1) 3 2). In group 1, six animals euthanatized at 0.5, 7, 30, 60, 90, 120 days after (n = 36). 2, 14, 32 24). Eyes enucleated, dissected, snap-frozen, they fixed for histology. Analysis of drug levels...
Purpose. To evaluate a tissue sealant (autologous cryoprecipitate activated with bovine thrombin) as an adjuvant in macular hole surgery. Methods. Sixty-nine patients stage 2, 3, or 4 full-thickness were enrolled consecutively prospective pilot study. Anatomic closure of the holes single operation was primary outcome. Fifty-eight had pre- and postoperative standardized measurements including best refracted visual acuity, reading speed, contrast sensitivity. Group A (45) holes; B (13)...
Bacillus cereus causes a highly fulminant endophthalmitis which usually results in blindness. We previously concluded that hemolysin BL (HBL), tripartite necrotizing pore-forming toxin, is probable virulence factor because it toxic to retinal tissue vitro and vivo. also determined B. produces additional toxins might contribute virulence. Here we fractionated crude culture supernatant by anion-exchange chromatography found toxicity was associated with phosphatidylcholine-preferring...