A5032770196- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Bariatric Surgery and Outcomes
- Liver Disease and Transplantation
- Cancer Genomics and Diagnostics
- Body Contouring and Surgery
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Obesity and Health Practices
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiation Dose and Imaging
- Pancreatitis Pathology and Treatment
- Renal cell carcinoma treatment
- Anesthesia and Pain Management
- Metastasis and carcinoma case studies
- TGF-β signaling in diseases
- Colorectal Cancer Treatments and Studies
- Diverticular Disease and Complications
- Frailty in Older Adults
- Gastrointestinal disorders and treatments
- Inflammatory Bowel Disease
Northwestern University
2015-2025
Northwestern Medicine
2022-2024
Jesse Brown VA Medical Center
2015-2024
Northwestern Memorial Hospital
2022
Cleveland Clinic
2019-2021
Case Western Reserve University
2018-2019
University School
2018
Midwestern University
2015
University of Illinois Chicago
2014-2015
Illinois College
2014
ABSTRACT Background and Objectives Gastric adenocarcinoma (GA) is commonly treated with open or minimally invasive surgery (MIS). The preferred surgical approach remains unclear. This study sought to assess utilization over time, compare complication rates by approach, identify predictors of experiencing complications. Methods Patients who underwent GA resection from 2016 2022 were identified in the American College Surgeons National Surgical Quality Improvement Program compared based on...
Purpose. The gravimetric method of weighing surgical sponges is used to quantify intraoperative blood loss. dry mass minus the wet gauze equals volume lost. This assumes that density equivalent water (1 gm/mL). study's purpose was validate assumption and correlate with hematocrit. Methods. 50 µL whole weighed from eighteen rats. A distilled control for each sample. averages were compared utilizing a Student's unpaired, one-tailed t-test. masses samples hematocrits using linear regression....
Background & Aims: Cirrhosis prevalence is increasing, yet costs associated with its chronic, complex care are poorly understood. The aim was to characterize the of for patients cirrhosis and compare them other chronic diseases such as heart failure (HF) obstructive pulmonary disease (COPD), which public health burden better recognized. Approach: Patients enrolled in Medicare Advantage plans from a large national insurer between 2011-2020 cirrhosis, HF, COPD were identified by ICD-9/-10...
Background Cirrhosis is a dynamic disease process leading to liver-related death, which has increased by over 65% the last decade. Unpredictable hepatic decompensation complications are major source of morbidity and mortality. Thus, accurately characterizing progression through discrete stages cirrhosis critical towards implementing timely intervention liver transplant (LT) waitlisting. Methods A retrospective, longitudinal, population-cohort study adult patients with from US metropolitan...
TGFβ has both tumor suppressive and promoting effects in colon cancer. Also, can affect the extent composition of inflammatory cells present tumors, contextually inhibiting inflammation. While tumors display intratumoral inflammation, contributions to this process are poorly understood. In human patients, we found that epithelial loss signaling was associated with increased burden; yet overexpression also These findings were recapitulated mutant APC models murine tumorigenesis, where...
Purpose Leukotrienes and prostaglandins, products of arachidonic acid metabolism, sustain both systemic lesion-localized inflammation. Tumor-associated Inflammation can also contribute to the pathogenesis colon cancer. Patients with inflammatory bowel disease (IBD) have increased risk developing The levels 5-lipoxygenase (5-LO), key enzyme for leukotrienes production, are in cancer specimens colonic dysplastic lesions. Here we report that Zileuton, a specific 5-LO inhibitor, prevent polyp...
Abstract Introduction The International Study Group of Liver Surgery's criteria stratifies post‐hepatectomy liver failure (PHLF) into grades A, B, and C. clinical significance these has not been fully established. Methods American College Surgeons National Surgical Quality Improvement Program (ACS NSQIP) hepatectomy‐targeted database was analyzed. Outcomes between patients without PHLF, with grade A B or C PHLF were compared. Univariate multivariable logistic regression performed. Results...
Objective: The primary objective was to determine the prognostic significance of circulating tumor DNA (ctDNA) in patients receiving neoadjuvant chemotherapy (NAC) for localized pancreatic ductal adenocarcinoma (PDAC) using digital droplet polymerase chain reaction (ddPCR). Summary and Background Data: Increasingly, ctDNA is being used clinical decision-making a variety solid malignancies. However, detection value KRAS as assessed by ddPCR during NAC has yet be characterized. Methods:...
Background and Objectives Patient selection remains paramount when developing adopting quality‐based assessment reimbursement models, enhanced recovery protocols. Gender is a patient characteristic known before surgery which can inform risk stratification. Our aim was to evaluate the effect of gender on intraoperative blood transfusions, operative time, length hospital stay, estimated loss (EBL) as well postoperative surgical site infections (SSIs), mortality. Methods Patients undergoing...
Venous thromboembolism (VTE) represents a major source of preventable morbidity and mortality is leading cause death in the US after cancer surgery. Previous research demonstrated variability VTE chemoprophylaxis prescribing, although it unknown how these rates compare with performance Veterans Health Administration (VHA).
BACKGROUND: A complete total mesorectal excision is the gold standard in curative rectal cancer surgery. Ensuring quality challenging a narrow pelvis, and obesity amplifies technical difficulties. Pelvimetry measurement of pelvic dimensions, but its role gauging preoperatively difficulty proctectomy largely unexplored. OBJECTIVE: To determine structural factors associated with incomplete following build predictive model for quality. DESIGN: Retrospective cohort study. SETTING: quaternary...
Abstract Background and Objectives Given increased utilization of neoadjuvant therapy (NAT) for gastric adenocarcinoma, practice patterns deviating from standard care (upfront resection) remain unknown. We sought to identify factors associated with NAT use survival outcomes among early‐stage cancers. Methods The National Cancer Database identified patients (T1N0M0) cancer (2010−2020). Multivariable logistic regression assessed characteristics compared upfront surgery. After 1:1 propensity...
Perioperative risk stratification is an essential component of preoperative planning for cancer surgery. While frailty has gained attention its utility in stratification, no studies have directly compared it to existing calculators. Therefore, the objective this study was compare American College Surgeons Surgical Risk Calculator (ACS-SRC), Revised Analysis Index (RAI-rev), and Modified Frailty (5-mFI). The primary outcomes were 30-day postoperative morbidity, mortality, unplanned...
The treatment of gastric adenocarcinoma (GA) continues to evolve. While neoadjuvant chemotherapy (NAC) has demonstrated emerging benefit, the optimal regimen, and sequence remain be firmly established.
Abstract Background and Objectives Neoadjuvant chemotherapy (NAC) chemoradiation (NCRT) have demonstrated improved survival for gastric cancer. However, the optimal neoadjuvant treatment remains unclear. We sought to evaluate perioperative histopathologic outcomes among treatments locoregional Methods The National Cancer Database queried patients who received NAC or NCRT followed by resection T2‐T4 and/or node‐positive cancer (2006–2018). Logistic Poisson regression assessed (30‐day...