A5016670999- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Genetics and Plant Breeding
- Meat and Animal Product Quality
- Gut microbiota and health
- Animal Behavior and Welfare Studies
- Genetic Associations and Epidemiology
- Probiotics and Fermented Foods
- Gastrointestinal motility and disorders
- Animal Genetics and Reproduction
- Animal Nutrition and Physiology
- Adipose Tissue and Metabolism
- Ruminant Nutrition and Digestive Physiology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
South China Agricultural University
2020-2025
Key Laboratory of Guangdong Province
2021
Greater feed efficiency (FE) is critical in increasing profitability while reducing the environmental impact of pig production. Previous studies that identified swine FE-associated bacterial taxa were limited either sampling sites or sequencing methods. This study characterized microbiomes within intestine FE contrasting Duroc × (Landrace Yorkshire) (DLY) pigs with a comprehensive representation diverse (ileum, cecum, and colon) metagenomic approach. A total 226 ranked according to their...
Abstract Genetic mapping to identify genes and alleles associated with or causing economically important quantitative trait variation in livestock animals such as pigs is a major goal animal genetic improvement. Despite recent advances high-throughput genotyping technologies, the resolution of remains poor due part low density genotyped variant sites. In this study, we overcame limitation by developing reference haplotype panel for based on 2259 whole genome-sequenced representing 44 pig...
Growth traits are important economic of pigs that controlled by several major genes and multiple minor genes. To better understand the genetic architecture growth traits, we performed a weighted single-step genome-wide association study (wssGWAS) to identify genomic regions candidate associated with days 100 kg (AGE), average daily gain (ADG), backfat thickness (BF) lean meat percentage (LMP) in Duroc pig population. In this study, 3945 individuals phenotypic genealogical information, which...
Backfat thickness (BFT) is complex and economically important traits in the pig industry, since it reflects fat deposition can be used to measure carcass lean meat percentage pigs. In this study, all 6,550 pigs were genotyped using Geneseek Porcine 50K SNP Chip identify SNPs related BFT search for candidate genes through genome-wide association analysis two Duroc populations. total, 80 SNPs, including 39 significant 41 suggestive 6 QTLs identified significantly associated with BFT. addition,...
Human mediated intra-continental exchange of genetic material among domesticated organisms has never been restricted to a single direction. The introduction pig breeds between China and Europe aims enhance economically important traits in local populations. However, the reciprocal introgression pattern, specifically role introgressed genes structural variations (SVs), remains underexplored. A global collection whole-genome resequencing data is utilized from 418 pigs generate comprehensive...
Abstract Background Carcass traits are important in pig breeding programs for improving pork production. Understanding the genetic variants underlies complex phenotypes can help explain trait variation pigs. In this study, we integrated a weighted single-step genome-wide association study (wssGWAS) and copy number (CNV) analyses to map variations genes associated with loin muscle area (LMA), depth (LMD) lean meat percentage (LMP) Duroc Results Firstly, performed analysis CNV detection using...
Heterozygosity can effectively reflect the diverse models of population structure and demographic history. However, genomic distribution heterozygotes correlation between regions heterozygosity (runs heterozygosity, ROHet) phenotypes are largely understudied in livestock. The objective this study was to identify ROHet Duroc pig genome, investigate relationships eight important economic traits. Here, we genotyped 3,770 American (S21) 2,096 Canadian (S22) pigs using 50 K single nucleotide...
Runs of homozygosity (ROH) are widely used to investigate genetic diversity, demographic history, and positive selection signatures livestock. Commercial breeds provide excellent materials reveal the landscape ROH shaped during intense process. Here, we GeneSeek Porcine 50K single-nucleotide polymorphism (SNP) Chip data 3,770 American Duroc (AD) 2,096 Canadian (CD) pigs analyze genome-wide ROH. First, showed that AD had a moderate differentiation with CD pigs, more abundant diversity...
Chest circumference (CC), abdominal (AC), and waist (WC) are regarded as important indicators for improving economic traits because they can reflect the growth physiological status in pigs. However, genetic architecture of CC, AC, WC is still elusive. Here, we performed single-trait multi-trait genome-wide association studies (GWASs) 2,206 American origin Duroc (AOD) 2,082 Canadian (COD) As a result, one novel quantitative trait locus (QTL) on Sus scrofa chromosome (SSC) was associated with...
Internal organ weight is an essential indicator of growth status as it reflects the level and development in pigs. However, associated genetic architecture has not been well explored because phenotypes are difficult to obtain. Herein, we performed single-trait multi-trait genome-wide association studies (GWASs) map markers genes with six internal traits (including heart weight, liver spleen lung kidney stomach weight) 1518 three-way crossbred commercial In summation, GWASs identified a total...
Abstract Background Pork quality can directly affect customer purchase tendency and meat traits have become valuable in modern pork production. However, genetic improvement has been slow due to high phenotyping costs. In this study, whole genome sequence (WGS) data was used evaluate the prediction accuracy of genomic best linear unbiased (GBLUP) for large-scale crossbred commercial pigs. Results We produced WGS (18,695,907 SNPs 2,106,902 INDELs exceed control) from 1,469 sequenced Duroc ×...
During the process of pork production, carcasses pigs are divided and sold, which provides better economic benefits market competitiveness for production than selling carcass as a whole. Due to significant cost post-slaughter phenotypic measurement, genetic architecture tenderloin weight (TLNW) rib (RIBW)—important components pig value—remain unknown. In this study, we conducted genome-wide association studies (GWAS) TLNW RIBW traits in population 431 Duroc × Landrace Yorkshire (DLY) pigs....
Feed efficiency (FE) is one of the most important economic traits in porcine industry. In this study, high-throughput RNA sequencing (RNA-seq) was first utilized for brain tissue transcriptome analysis pigs to indicate potential genes and biological pathways related FE pigs. A total 8 with either extremely high-FE group (HE-group) or low-FE (LE-group) were selected from 225 Duroc × (Landrace Yorkshire) (DLY) transcriptomic analysis. RNA-seq performed determine differentially expressed (DEGs)...
Runs of homozygosity (ROH) are widely used to estimate genomic inbreeding, which is linked inbreeding depression on phenotypes. However, the adverse effects specific homozygous regions phenotypic characteristics rarely studied in livestock. In this study, 50 K SNP data 3,770 S21 Duroc (American origin) and 2,096 S22 (Canadian pigs were investigate harmful ROH five economic traits. The results showed that two lines had different numbers distributions unfavorable ROHs, may be related selection...
Meat quality is of importance in consumer acceptance and purchasing tendency pork. However, the genetic architecture pork meat traits remains elusive. Herein, we conducted genome-wide association studies to detect single nucleotide polymorphisms (SNPs) genes affecting pH color (L*, lightness; a*, redness; b*, yellowness) 1518 three-way crossbred pigs. All individuals were genotyped using GeneSeek Porcine 50K BeadChip. In sum, 30 SNPs 20 are found be associated with eight traits. Notably, one...
Loin muscle area (LMA) is an important target trait of pig breeding. This study aimed to identify single nucleotide polymorphisms (SNPs) and genes associated with LMA in the Duroc×(Landrace×Yorkshire) crossbred pigs (DLY).A genome-wide association was performed using Illumina 50K chip map genetic marker 511 DLY (255 boars 256 sows).After quality control, we detected 35,426 SNPs, including six SNPs significantly pigs, MARC0094338 ASGA0072817 being two key responsible for 1.77% 2.48%...
Abstract In the pork industry chain, carcass cutting is crucial for enhancing commercial value of carcasses. However, genetic mechanisms underlying component weights remain poorly understood. Here, we used a combined genome-wide association study (GWAS) approach that integrated single- and multi-locus models to map markers genes associated with seven components in Duroc × Landrace Yorkshire (DLY) pigs. As GWAS captures more single nucleotide polymorphisms (SNPs) large effects than...
The number of teats is a crucial reproductive trait with significant economic implications on maternal capacity and litter size. Consequently, improving this essential to facilitate genetic selection for increased In study, we performed genome-wide association study (GWAS) the in three-way crossbred commercial Duroc × (Landrace Yorkshire) (DLY) pig population comprising 1518 animals genotyped 50K BeadChip. Our analysis identified quantitative loci (QTL) teats, containing ABCD4 VRTN genes...
Body conformation is the most direct production index, which can fully reflect pig growth status and closely related to critical economic traits. In this study, we conducted a genome-wide association study (GWAS) on body traits in population of 1518 Duroc × (Landrace Yorkshire) commercial pigs. These included length (BL), height (BH), chest circumference (CC), abdominal (AC), waist (WC). Both mixed linear model (MLM) fixed random circulating probability unification (FarmCPU) approaches were...
The establishment of a robust gut microbiota in piglets during their early developmental stage holds the potential for long-term advantageous effects. However, optimal timeframe introducing probiotics to achieve this outcome remains uncertain. In context investigation, we conducted longitudinal assessment fecal 63 at three distinct pre-weaning time points. Simultaneously, gathered vaginal and samples from 23 sows. Employing 16S rRNA gene metagenomic sequencing methodologies, comprehensive...
Abstract Genetic mapping to identify genes and alleles associated with or causing economically important quantitative trait variation in livestock animals such as pigs is a major goal the genetic improvement animals. Despite recent advances high throughput genotyping technologies, resolution of remains poor due part low density genotyped variant sites. In this study, we overcame limitation by developing reference haplotype panel for based on 2,259 whole genome sequenced representing 44 pig...
Abstract This study aimed at identifying genes associated with loin muscle area (LMA), depth (LMD) and backfat thickness (BFT). We performed single‐trait multi‐trait genome‐wide association studies (GWASs) after genotyping 685 Duroc × (Landrace Yorkshire) (DLY) pigs using the Geneseek Porcine 50K SNP chip. In GWASs, we identified two, eight two significant SNPs LMA, LMD BFT, respectively, searched within 1 Mb region near relevant functions as candidate genes. Consequently, one ( DOCK5 ),...
The pig bone weight trait holds significant economic importance in southern China. To expedite the selection of breeding, we conducted molecular genetic research on these specific traits. These traits encompass scapula (SW), front leg (including humerus and ulna) (FLBW), hind femur tibia) (HLBW), spine (SBW). Up until now, structure related to has not been thoroughly explored, primarily due challenges associated with obtaining phenotype data. In this study, utilized genome-wide association...
Genetic variation in the regulation of gene expression contributes substantially to phenotypic variation. Understanding how DNA sequences and epigentic modifications leads remains a challenging task. In hybrid animals where cellular environments are homogeneous, differences between paternal maternal alleles must be due cis sequence or epigenic differences. Therefore, mapping is powerful approach efficiently identify characterize genes under through mechanisms cis. this study, using...