A5101721707- Gut microbiota and health
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Nutritional Studies and Diet
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Genetic Associations and Epidemiology
- Animal Nutrition and Physiology
- Oral microbiology and periodontitis research
- Ferroptosis and cancer prognosis
- Meat and Animal Product Quality
- Diet and metabolism studies
- Animal Behavior and Welfare Studies
- Apelin-related biomedical research
- Tea Polyphenols and Effects
- Genetic factors in colorectal cancer
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- Coenzyme Q10 studies and effects
- Congenital heart defects research
- Tryptophan and brain disorders
- Dietary Effects on Health
Tianjin Fourth Hospital
2025
Huashan Hospital
2022-2024
Fudan University
2022-2024
Shanghai Jiao Tong University
2024
South China Agricultural University
2020-2024
Union Hospital
2024
Tsinghua University
2024
Qingdao University
2022-2024
Affiliated Hospital of Qingdao University
2022-2024
Vanderbilt University
2014-2024
Greater feed efficiency (FE) is critical in increasing profitability while reducing the environmental impact of pig production. Previous studies that identified swine FE-associated bacterial taxa were limited either sampling sites or sequencing methods. This study characterized microbiomes within intestine FE contrasting Duroc × (Landrace Yorkshire) (DLY) pigs with a comprehensive representation diverse (ileum, cecum, and colon) metagenomic approach. A total 226 ranked according to their...
The dynamic changes in microbial diversity during the aerobic composting of agricultural crop straw with additives were evaluated using high-throughput sequencing at four phases (mesophilic, thermophilic, cooling and maturation phases). In addition, physicochemical parameters system determined this study. fermentation time thermophilic period was prolonged addition urea or combined a agent. ratio C/N germination index variation indicated that favorable for composting, because directly...
Altered gut microbiota has been reported in individuals with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Previous research suggested that specific bacterial species might be associated the decline of function. However, evidence was insufficient, results were inconsistent. To determine whether there is an alteration patients MCI AD to investigate its correlation clinical characteristics, fecal samples from 94 cognitively normal controls (NC), 125 participants MCI, 83...
Abstract Background More teats are necessary for sows to nurse larger litters provide immunity and nutrient piglets prior weaning. Previous studies have reported the strong effect of an insertion mutation in Vertebrae Development Associated ( VRTN ) gene on Sus scrofa chromosome 7 (SSC7) that increased number thoracic vertebrae teat pigs. We used genome-wide association (GWAS) map genetic markers genes associated with two Duroc pig populations different backgrounds. A single marker method...
Vortioxetine hydrobromide is a common clinical medication for major depressive disorder (MDD). However, it remains unclear whether vortioxetine acts by affecting the structure and composition of gut microbiota. Here, we analyzed fecal samples from 28 healthy controls (HCs) 26 patients with MDD before treatment hydrobromide, at 4 weeks after treatment, 8 treatment. High-throughput pyrosequencing showed that, according to Chao1 Shannon indices, bacterial α-diversity was higher in than HCs ( p...
Objective To examine the diagnostic and prognostic value of multimodal ultrasound serum human epidermal growth factor receptor 2 (HER2) Ki-67 antigen (Ki-67) testing for breast cancer. Methods We enrolled 65 patients with cancer admitted to Tianjin Fourth Centre Hospital between March 2018 2019 as study group, while control group consisted benign nodules during same time period. All cases underwent elastography (UE), contrast-enhanced ultrasonography (CEUS), examination, HER2 determine...
Abstract Colonization of specific bacteria in the human mouth was reported to be associated with gastric cancer risk. However, previous studies were limited by retrospective study designs and low taxonomic resolutions. We performed a prospective case‐control nested within three cohorts investigate relationship between oral microbiome Shotgun metagenomic sequencing employed characterize prediagnostic buccal samples from 165 cases 323 matched controls. Associations overall microbial richness...
Despite the knowledge of many genetic alterations present in ovarian cancer, complexity this disease precludes placing its biology into a simple conceptual framework. Lysyl oxidase (LOX) is an extracellular matrix enzyme that catalyzes cross-linking collagens or elastin compartment. A novel polymorphism LOX gene, G473A (rs1800449), has been reported as being risk factor for different diseases. The objective study was to investigate association between and susceptibility cancer Chinese...
PURPOSE Gut microbiota play an important role in human health, including cancer. Cancer and its treatment, turn, may alter the gut microbiome. To understand this complex relationship, we profiled microbiome of 356 Vietnamese patients with breast MATERIALS AND METHODS Stool samples were collected before chemotherapy, 162 pre- 194 postsurgery. The was measured by shotgun metagenomic sequencing. Associations microbial diversity, taxa abundance, health index (GMHI) sociodemographic, clinical...
Diet is known to affect human gut microbiome composition; yet, how diet affects functionality remains unclear. We compared the diversity and abundance/presence of fecal metabolic pathways among individuals according their long-term quality. In 2 longitudinal cohorts, we assessed participants' usual diets via repeated surveys during 1996–2011 collected a stool sample in 2015–2018. Participants who maintained healthy or unhealthy (i.e., stayed highest lowest quintile score throughout...
Non-alcoholic fatty liver disease (NAFLD) has been linked to altered gut microbiome; however, evidence from large population-based studies is limited. We compared microbiome profiles of 188 male and 233 female NAFLD cases with 571 567 controls two longitudinal urban Chinese adults. History was assessed during surveys administered in 2004–2017. Microbiota were using 16S rRNA sequencing stool samples collected 2015–2018. Associations diversity composition evaluated by generalized linear or...
Abstract Background Coenzyme Q10 (CoQ10) is a ubiquitous molecule in living organisms serving as cofactor energy production. Epidemiological studies have reported low CoQ10 levels being associated with an increased risk of various cancers. We conducted the first study to evaluate association concentrations lung cancer risk. Methods A nested case‐control including 201 cases and 395 matched controls from Southern Community Cohort Study was conducted. Plasma were measured using high‐performance...
Abstract Background Improving feed efficiency is economically and environmentally beneficial in the pig industry. A deeper understanding of essential on many levels for its highly complex nature. The aim this project to explore relationship between fecal metabolites efficiency-related traits, thereby identifying that may assist screening pigs. Results We performed metabolomics analysis 50 individuals selected from 225 Duroc x (Landrace Yorkshire) (DLY) commercial pigs, 25 with an extremely...
Background . Proper rRNA depletion is crucial for the successful utilization of FFPE specimens when studying gene expression. We performed a study to evaluate two major methods: Ribo-Zero and RNase H. RNAs extracted from 4 samples were treated with methods in duplicate sequenced (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>N</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">16</mml:mn></mml:math>). evaluated their reducibility, ability detect RNA, molecularly...
Chest circumference (CC), abdominal (AC), and waist (WC) are regarded as important indicators for improving economic traits because they can reflect the growth physiological status in pigs. However, genetic architecture of CC, AC, WC is still elusive. Here, we performed single-trait multi-trait genome-wide association studies (GWASs) 2,206 American origin Duroc (AOD) 2,082 Canadian (COD) As a result, one novel quantitative trait locus (QTL) on Sus scrofa chromosome (SSC) was associated with...
Lead (Pb) in soil may accumulate crops and enter the human body. This study aimed to understand speciation transformation accumulation characteristics of exogenous Pb calcareous with or without application amendments. Field experiments continuous maize cultivation have been carried out for two years. The results showed that contents total were slightly lower 2016 than 2015 same treatments; however, no significant difference between years was observed. Soil existed mainly residual fraction...
Abstract Background Antiapoptosis is a major factor in the resistance of tumor cells to chemotherapy and radiotherapy. Thus, activation cell pyroptosis may be an effective option deal with antiapoptotic cancers such as esophageal adenocarcinoma (EAC). Methods Differential expression ubiquitin‐like versus PHD ring finger structural domain 1 (UHRF1) EAC near normal tissues was analyzed, well prognostic impact on survival EAC. Also, same study done for globular adiponectin (gAD)....
Do differences in heritable genetic factors explain some of the difference age at natural menopause (ANM) among populations? One single nucleotide polymorphism (SNP)-ANM association (rs16991615) detected European women was replicated Iranian women. Genetics plays an important role ANM, and well-powered genome-wide studies (GWAS) ANM performed have discovered many statistically significant SNP-ANM associations. Average varies by ethnicity, population-specific ANM-associated alleles may part...