A5022919872- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Single-cell and spatial transcriptomics
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Cancer and Skin Lesions
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- BRCA gene mutations in cancer
- Sarcoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- DNA Repair Mechanisms
- Reproductive tract infections research
- Genital Health and Disease
- Cervical Cancer and HPV Research
- Salivary Gland Tumors Diagnosis and Treatment
- Prostate Cancer Treatment and Research
National Hospital of Pediatrics
2019-2024
Hanoi Medical University
2020-2024
Agricultural Genetics Institute
2023
Hanoi Medical University Hospital
2023
Hôpital Laennec
2002
Hôpital Nord
2002
Abstract Background Late detection of hepatocellular carcinoma (HCC) results in an overall 5-year survival rate less than 16%. Liquid biopsy (LB) assays based on detecting circulating tumor DNA (ctDNA) might provide opportunity to detect HCC early noninvasively. Increasing evidence indicates that ctDNA using mutation-based is significantly challenged by the abundance white blood cell-derived mutations, non-tumor tissue-derived somatic mutations plasma, and mutational heterogeneity. Methods...
Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published date demanded a very high-depth sequencing, resulting an elevated price test. Herein, we developed multimodal assay called SPOT-MAS (screening presence by methylation size) simultaneously profile methylomics, fragmentomics, copy number, end...
Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published date demanded a very high-depth sequencing, resulting an elevated price test. Herein, we developed multimodal assay called SPOT-MAS (screening presence by methylation size) simultaneously profile methylomics, fragmentomics, copy number, end...
Abstract Comprehensive profiling of actionable mutations in non-small cell lung cancer (NSCLC) is vital to guide targeted therapy, thereby improving the survival rate patients. Despite high incidence and mortality NSCLC Vietnam, mutation profiles Vietnamese patients have not been thoroughly examined. Here, we employed massively parallel sequencing identify alterations major driver genes ( EGFR , KRAS, NRAS, BRAF ALK ROS1 ) 350 We showed that exhibited most frequently (35.4%) KRAS (22.6%),...
Aim: This study exploited hepatocellular carcinoma (HCC)-specific circulating DNA methylation profiles to improve the accuracy of a current screening assay for HCC patients in high-risk populations. Methods: Differentially methylated regions cell-free between 58 nonmetastatic and 121 with liver cirrhosis or chronic hepatitis were identified used train machine learning classifiers. Results: The model could distinguish from non-HCC validation cohort, an area under curve 0.84. Combining these...
PURPOSE Gut microbiota play an important role in human health, including cancer. Cancer and its treatment, turn, may alter the gut microbiome. To understand this complex relationship, we profiled microbiome of 356 Vietnamese patients with breast MATERIALS AND METHODS Stool samples were collected before chemotherapy, 162 pre- 194 postsurgery. The was measured by shotgun metagenomic sequencing. Associations microbial diversity, taxa abundance, health index (GMHI) sociodemographic, clinical...
Abstract Background Cervical cancer remains a leading cause of death, particularly in developing countries. WHO screening guidelines recommend human papilloma virus (HPV) detection as means to identify women at risk cervical cancer. While HPV testing identifies those risk, it does not specifically distinguish individuals with neoplasia. We investigated whether quantitative molecular test that measures methylated DNA markers could high-risk lesions the cervix accuracy. Results Marker...
Abstract Targeted therapy with tyrosine kinase inhibitors (TKI) provides survival benefits to a majority of patients non-small cell lung cancer (NSCLC). However, resistance TKI almost always develops after treatment. Although genetic and epigenetic alterations have each been shown drive in line models, clinical evidence for their contribution the acquisition remains limited. Here, we employed liquid biopsy simultaneous analysis changes 122 Vietnamese NSCLC undergoing displaying acquired...
Hereditary cancer syndromes (HCS) are responsible for 5-10% of cases. Genetic testing to identify pathogenic variants associated with predisposition has not been routinely available in Vietnam. Consequently, the prevalence and genetic landscape HCS remain unknown.1165 Vietnamese individuals enrolled at our laboratory 2020. We performed analysis germline mutations 17 high- moderate- penetrance genes by next generation sequencing.A total 41 11 were detected 3.2% individuals. The carrier...
Molecular subtypes play an important role in predicting prognosis and guiding treatment for breast cancer. Having a better knowledge of ethnic molecular features is essential.Determining the distribution various cancer investigating relationship between these clinicopathological features.Retrospective data was collected from Hanoi National Cancer Hospital Bach Mai that included 274 women diagnosed with invasive January 2017 June 2019. Patients were categorized into five according to 2015 St....
The identification and quantification of actionable mutations are critical importance for effective genotype-directed therapies, prognosis drug response monitoring in patients with non-small-cell lung cancer (NSCLC). Although tumor tissue biopsy remains the gold standard diagnosis NSCLC, analysis circulating DNA (ctDNA) plasma, known as liquid biopsy, has recently emerged an alternative noninvasive approach exploring genetic constitution. In this study, we developed a protocol using...
Background: Tumor budding (Bd) has been demonstrated to be a promising prognostic factor in many carcinomas and gastric cancer. It may represent an optimal additional parameter that is helpful for risk stratification adenocarcinoma. Hence, the present research was designed predict survival outcomes of cancer Vietnam, applying tumor criteria International Budding Consensus Conference (ITBCC) 2016. Methods: The study conducted on 109 patients who underwent surgery but did not receive...
Extranodal natural killer (NK)/T-cell lymphoma, nasal type is a rare, aggressive, and poor prognostic subtype. The concurrent chemoradiotherapy followed by chemotherapy showed relatively high response rate the toxicity due to treatment acceptable. study attempted report clinicopathological features, survival outcome, rates of stages I-II, ENKTL patients treated with CCRT adjuvant VIPD in Vietnam.
mutations are uncommon in non-small cell lung cancer (NSCLC), accounting for less than 5% of all NSCLC cases. The utilization targeted therapies non-V600E
The combination of doxorubicin and paclitaxel (AP) is widely used in our country for the neoadjuvant treatment breast cancer as well metastatic cancer. AP regimen has shown promise a therapy that improves pathological complete response (pCR), increases rate conservative surgery, survival patients. However, up to now, no research evaluated this advanced cancer, especially with 10-year period follow-up.This retrospective analysis reviewed 126 patients inoperable stage III who received...
Background The standard treatment for localized osteosarcoma is neoadjuvant chemotherapy before surgery, followed by adjuvant chemotherapy. Our aim was to report the rate of histopathological response extremity in Vietnam. Methods We performed a retrospective study stage II conventional patients under 40 years-old who received MAP regimen as at Vietnam National Cancer Hospital between June 2019 and 2022. Histopathological evaluated using Huvos grading system, which good defined necrotic 90%...
Bachmeyer, Claude; Alovor, Guy; Chatelain, Denis; Khuoy, Louis; Turc, Yves; Danon, Olivier; Laurette, Frederic; Cazier, Alain; N'Guyen, Van Author Information
Breast cancer is a heterogeneous disease with different tumor subtypes. Identifying risk categories will help make better treatment decisions. Hence, this study aimed to predict the survival outcomes of invasive breast in Vietnam, using St Gallen 2007 classification. This was conducted on 501 patients who had surgical operations, but not received neoadjuvant chemotherapy, from 2011 2013. The clinicopathological characteristics were recorded. Immunohistochemistry staining performed ER, PR,...
Uterine tumor resembling ovarian sex cord (UTROSCT) is a rare indolent stromal neoplasm of unclear histogenesis with distinct histopathological entity. Immunophenotypes positivity are the most significant information to confirm diagnosis. We present case 61-year-old female polypoid mass in uterus which was successfully removed by surgical resection as hysterectomy. The pathological diagnosis UTROSCT, characterized microscopically images and immunohistochemical features calretinin, CD99, WT1...
Background: Aberrant of p53 and Bcl2 genes cause changes in the quantity quality their proteins contribute to pathogenesis some cancer types including breast cancer. Expression were associated adverse clinical outcomes Purpose: To predict survival invasive Vietnam, using immunohistochemical expression p53, proteins. Methods: The current study was conducted on 526 patients who had surgical operations, but not received neo-adjuvant chemotherapy, from 2011 2014. clinicopathological...
Abstract A complex of G719X and S768I mutations is infrequently observed, constituting less than 0.3% all EGFR ‐positive non‐small cell lung cancer (NSCLC), the response to first‐line TKIs inconsistent in literature. In this study, we report a patient with metastatic carrying rare compound who benefited from treatment gefitinib Vietnam. This had prolonged lasting over 44 months first‐generation TKI. He continued take without experiencing serious adverse events. NSCLC mutation revealed good gefitinib.
Lactating adenoma is a rare breast tumor which commonly found in late pregnancy or lactation period. Despite its benign nature, lactating might develop aggressively and can be misdiagnosed as cancer.