A5067383590- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Genetics, Bioinformatics, and Biomedical Research
- Gene expression and cancer classification
- Advanced biosensing and bioanalysis techniques
University Medical Center HCMC
2023-2025
Ho Chi Minh City Medicine and Pharmacy University
2023-2024
University Medical Center
2023-2024
Faculty of Public Health
2023
University Hospital and Clinics
2023
Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published date demanded a very high-depth sequencing, resulting an elevated price test. Herein, we developed multimodal assay called SPOT-MAS (screening presence by methylation size) simultaneously profile methylomics, fragmentomics, copy number, end...
Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published date demanded a very high-depth sequencing, resulting an elevated price test. Herein, we developed multimodal assay called SPOT-MAS (screening presence by methylation size) simultaneously profile methylomics, fragmentomics, copy number, end...
Anastomotic leakage (AL) is a determining factor of morbidity and mortality after esophagectomy. Adequate perfusion the gastric conduit crucial for AL prevention. This study aimed to determine whether intraoperative angiography using indocyanine green (ICG) fluorescence improves incidence McKeown minimally invasive esophagectomy (MIE) with via substernal route (SR).
<title>Abstract</title> <bold>Background:</bold> Gastric cancer (GC) remains one of the leading causes cancer-related mortality worldwide. While laparoscopic gastrectomy (LG) has been widely adopted for early and locally advanced gastric (AGC), its safety oncological efficacy in T4a GC remain unclear. To date, no randomized controlled trials have specifically examined role LG treatment GC. This study aims to provide robust evidence comparing short- long-term outcomes distal (LDG) versus open...
Abstract Background Substernal (ST) and posterior mediastinal (PM) routes are the two most common for reconstruction after esophagectomy with cervical anastomosis. Recent evidence showed similar outcomes between routes; thus, superior choice remained controversial. This study aimed to compare short-term of ST PM route esophageal cancer (EC). Method retrospective cohort included 132 patients who underwent McKeown minimally invasive (MIE) gastric conduit EC March 2015 December 2022. Among...
This study aimed to evaluate the effectiveness of modified Billroth-II with a hinged anti-peristaltic afferent loop by comparing it Roux-en-Y method.
Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published date demanded a very high-depth sequencing, resulting an elevated price test. Herein, we developed multimodal assay called SPOT-MAS (Screening Presence Of Tumor by Methylation And Size) simultaneously profile methylomics, fragmentomics, copy...
Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published date demanded a very high-depth sequencing, resulting an elevated price test. Herein, we developed multimodal assay called SPOT-MAS (Screening Presence Of Tumor by Methylation And Size) simultaneously profile methylomics, fragmentomics, copy...
Stomach partitioning gastrojejunostomy (SPGJ) was introduced to deal with delayed gastric emptying (DGE). This study aimed compare the short- and long-term outcomes of SPGJ versus conventional (CGJ).
Purpose: Laparoscopic proximal gastrectomy (LPG) has been a standard surgery for early gastric cancer in the upper third of stomach and large esophagogastric junction gastrointestinal stromal tumor. However, how to reconstruct after LPG is still debated. This study aimed evaluate results with double-flap reconstruction. Methods: A retrospective was performed 14 patients undergoing reconstruction or tumors from 2018 2021. We evaluated postoperative complications, gastroesophageal reflux...
The association between postoperative complications and long-term survival after laparoscopic gastrectomy (LG) for gastric cancer (GC) remains uncertain. This study aimed to determine the incidence risk factors of evaluate their impact on outcomes in patients undergoing LG.
Abstract Background: The functional end-to-end anastomosis (FEEA) and overlap methods for reconstruction after totally laparoscopic total gastrectomy (TLTG) are technically challenges. We developed a T-shaped FEEA to facilitate technique. This study aimed compare the short- long-term outcomes between TLTG gastric cancer (GC). Method: cohort enrolled 84 patients who underwent GC using linear stapler August-2015 October-2020. Among them, 40 FEEA, while 44 method. Short-term encompassed...
<title>Abstract</title> <bold>Background:</bold> No studies on neoadjuvant chemotherapy for gastric cancer (GC) with T4b stage were reported. This study aimed to assess the effectiveness of using DCS regimen (docetaxel, cisplatin, and S-1) GC <bold>Methods:</bold> Forty-three patients diagnosed surgical or clinical received three four preoperative cycles therapy followed by gastrectomy lymphadenectomy between Jan-2018 Dec-2022. Short-tern outcomes including tumor response, completion...
Background Cell-free circulating DNA (cfDNA) fragments exhibit non-random patterns in their length (FLEN), end-motif (EM), and distance to nucleosome position (ND). While these cfDNA features have shown promise as inputs for machine learning deep models early cancer detection, most studies utilize them raw inputs, overlooking the potential benefits of pre-processing extract cancer-specific features. This study aims enhance detection accuracy by developing a novel approach feature extraction...
Abstract Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published date demanded a very high-depth sequencing, resulting an elevated price test. Herein, we developed multimodal assay called SPOT-MAS (Screening Presence Of Tumor by Methylation And Size) simultaneously profile methylomics, fragmentomics,...
Introduction Lymph node (LN) metastasis happens even in early gastric cancer (GC) LN stations that are not adjacent to the primary tumor. Total or subtotal gastrectomy (TG sTG) can be performed middle third of GC if negative proximal margin is maintained. These procedures differed extent dissection; therefore, oncology considerations must taken into consideration when selecting appropriate procedure. Methods This was a cross-sectional study involving 98 patients suffering from middle-third...