Thuy Thi Thu Tran
A5024071126- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Cellular transport and secretion
- Genomic variations and chromosomal abnormalities
- RNA regulation and disease
- Plant Pathogenic Bacteria Studies
- Hepatitis C virus research
- COVID-19 and Mental Health
- Crop Yield and Soil Fertility
- Plant Pathogens and Fungal Diseases
- Animal Virus Infections Studies
- Chromosomal and Genetic Variations
- Plant Genetic and Mutation Studies
- Lipid Membrane Structure and Behavior
- Genetics and Plant Breeding
- Retinal Development and Disorders
- Complement system in diseases
- Ferroptosis and cancer prognosis
- Digital Mental Health Interventions
- Immune Cell Function and Interaction
- Genetic Mapping and Diversity in Plants and Animals
- Genetic factors in colorectal cancer
- Invertebrate Immune Response Mechanisms
- CRISPR and Genetic Engineering
Hanoi University
2023
Medical Genetics Center
2023
Agricultural Genetics Institute
2015-2023
University of California, San Diego
2017-2019
Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2015
Institut de Recherche pour le Développement
2015
Abstract Background Late detection of hepatocellular carcinoma (HCC) results in an overall 5-year survival rate less than 16%. Liquid biopsy (LB) assays based on detecting circulating tumor DNA (ctDNA) might provide opportunity to detect HCC early noninvasively. Increasing evidence indicates that ctDNA using mutation-based is significantly challenged by the abundance white blood cell-derived mutations, non-tumor tissue-derived somatic mutations plasma, and mutational heterogeneity. Methods...
Vesicle budding for Golgi-to-plasma membrane trafficking is a key step in secretion. Proteins that induce curvature of the Golgi are predicted to be required, by analogy vesicle from other membranes. Here, we demonstrate GOLPH3, upon binding phosphoinositide PI4P, induces synthetic membranes vitro and cells. Moreover, efficient critically depends on ability GOLPH3 curve membrane. Interestingly, uncoupling its partner MYO18A results extensive membranes, producing dramatic tubulation Golgi,...
Breast cancer causes the most cancer-related death in women and is costliest US regarding medical service prescription drug expenses. screening recommended by health authorities US, but current efforts are often compromised high false positive rates. Liquid biopsy based on circulating tumor DNA (ctDNA) has emerged as a potential approach to screen for cancer. However, detection of breast cancer, particularly early stages, challenging due low amount ctDNA heterogeneity molecular...
Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published date demanded a very high-depth sequencing, resulting an elevated price test. Herein, we developed multimodal assay called SPOT-MAS (screening presence by methylation size) simultaneously profile methylomics, fragmentomics, copy number, end...
Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published date demanded a very high-depth sequencing, resulting an elevated price test. Herein, we developed multimodal assay called SPOT-MAS (screening presence by methylation size) simultaneously profile methylomics, fragmentomics, copy number, end...
Although transmembrane C-type lectins (CLs) are known to initiate immune signaling, the participation and mechanism of action soluble CLs have remained enigmatic. In this study, we found that M-ficolin, a conserved CL monocyte origin, overcomes its lack membrane-anchor domain by docking constitutively onto receptor, G protein-coupled receptor 43 (GPCR43), form pathogen sensor-cum-signal transducer. On encountering microbial invaders, M-ficolin-GPCR43 complex activates NF-κB cascade...
Induced point mutations are important genetic resources for their ability to create hypo- and hypermorphic alleles that useful understanding gene functions breeding. However, such mutant populations have only been developed a few temperate maize varieties, mainly B73 W22, yet no tropical inbred lines mutagenized made available the public date. We novel Ethyl Methanesulfonate (EMS) induced mutation resource in comprising 2050 independent M2 families elite ML10. By phenotypic screening, we...
Aims: Early detection of colorectal cancer (CRC) provides substantially better survival rates. This study aimed to develop a blood-based screening assay named SPOT-MAS ('screen for the presence tumor by DNA methylation and size') early CRC with high accuracy. Methods: Plasma cell-free samples from 159 patients nonmetastatic 158 healthy controls were simultaneously analyzed fragment length profiles. We then employed deep neural network signatures build classification model. Results: The model...
Meristems are central to plant growth and development, yet evidence of directly manipulating this control improve crop yield is scarce. Kernel row number (KRN) an important agronomic trait that can affect maize (Zea mays L.) yield. However, difficult select by phenotyping, since it highly variable in the mixed genetic backgrounds early selfing generations. This study sought marker-assisted backcrossing (MABC) a weak allele FASCIATED EAR 2 known inflorescence meristem size, but effect which...
The aim of this study is to describe a research protocol multi-country randomized controlled trial investigate the effect smartphone CBT stress management program on improving depression and other health- work-related outcomes among hospital nurses in Vietnam Thailand during COVID-19 epidemic as part COCONATS project. two-arm, parallel control trial. Hospital (N = 1,500) will be recruited Thailand, those who meet criteria randomly allocated intervention or (treatment usual) group. A...
Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published date demanded a very high-depth sequencing, resulting an elevated price test. Herein, we developed multimodal assay called SPOT-MAS (Screening Presence Of Tumor by Methylation And Size) simultaneously profile methylomics, fragmentomics, copy...
Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published date demanded a very high-depth sequencing, resulting an elevated price test. Herein, we developed multimodal assay called SPOT-MAS (Screening Presence Of Tumor by Methylation And Size) simultaneously profile methylomics, fragmentomics, copy...
Abstract Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published date demanded a very high-depth sequencing, resulting an elevated price test. Herein, we developed multimodal assay called SPOT-MAS (Screening Presence Of Tumor by Methylation And Size) simultaneously profile methylomics, fragmentomics,...