A5100350225- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Infectious Diseases and Tuberculosis
- Liver Disease Diagnosis and Treatment
- Fire effects on ecosystems
- Bacteriophages and microbial interactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis C virus research
- Sepsis Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- COVID-19 Clinical Research Studies
- Drug Transport and Resistance Mechanisms
- Diagnosis and treatment of tuberculosis
- Tracheal and airway disorders
- Long-Term Effects of COVID-19
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Resistance in Bacteria
- Liver physiology and pathology
- Tendon Structure and Treatment
- Advanced Computing and Algorithms
- Osteomyelitis and Bone Disorders Research
- Connective Tissue Growth Factor Research
Yunnan University
2025
First Hospital of China Medical University
2024
China Medical University
2024
Beijing Chest Hospital
2013-2024
Capital Medical University
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2023
Beijing Children’s Hospital
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2018-2023
Chongqing Medical University
2018-2023
Sichuan University
2023
Abstract Background In Traditional Chinese Medicine (TCM), tongue diagnosis has been an important diagnostic method for the last 3000 years. Tongue is a non-invasive, simple and valuable tool. TCM treats coating on very sensitive scale that reflects physiological pathological changes in organs, especially spleen stomach. can diagnose disease severity determine syndrome (“Zheng” Chinese). The biological bases of different appearances are still poorly understood lack systematic investigation...
Purpose The present study aimed to explore the risk factors for tuberculous meningitis (TBM) among patients with tuberculosis (TB). Methods This retrospective was conducted on TB who were hospitalized in Beijing Chest Hospital between January 2012 and December 2019. Demographic clinical data of extracted from electronic medical records using a standardized collection system. Logistic regression used analyze associated TBM. Results Of total number 22,988 cases enrolled, 3.1% TBM, which...
The novel SARS-CoV-2 caused a large number of infections and deaths worldwide. Thus, new ideas for an appropriated assessment patients' condition clinical treatment are utmost importance. Therefore, in this study, the laboratory parameters patients with coronavirus disease 2019 (COVID-19) were evaluated to identify correlation between cytokine expression other parameters. A retrospective single-center study was performed Wuhan, involving 83 severe or critical COVID-19 admitted intensive care...
Severe pulmonary tuberculosis (STB) is a life‑threatening condition with high economic and social burden. The present study aimed to screen for distinct proteins in different stages of TB identify biomarkers better understanding progression pathogenesis. Blood samples were obtained from 81 patients STB, 80 mild (MTB) 50 healthy controls. Differentially expressed identified using liquid chromatography‑tandem mass spectrometry‑based label‑free quantitative proteomic analysis. Functional...
Nonalcoholic steatohepatitis (NASH) is an increasingly prevalent nonalcoholic fatty liver disease, characterized by inflammatory cell infiltration and hepatocellular damage. Mammalian target of rapamycin complex 1 (mTORC1) has been investigated extensively in the context cancer, including carcinoma. However, role mTORC1 NASH remains largely unknown. activity macrophages human mild severe was compared. Mice with macrophage-specific deletion regulatory-associated protein mTOR (Raptor) subunit...
Cell-free DNA (cf-DNA) in blood represents a promising damage response triggered by virus infection or trauma, tumor, etc. Hantavirus primarily causes two diseases: haemorrhagic fever with renal syndrome (HFRS) and cardiopulmonary (HCPS), depending on different species. The aim of this study was to evaluate plasma cf-DNA levels acute phase HFRS, correlate disease severity Hanttan (HTNV) load. We observed the appearance 166 samples from 76 HFRS patients: peaked at hypotensive stage then...
A comparative performance evaluation of the novel Xpert MTB/RIF Ultra (Xpert Ultra) and (Xpert) for tuberculous meningitis (TBM) diagnosis was performed. The cerebrospinal fluids suspected TBM patients were collected consecutively subjected to smear microscopy, culture, Xpert, Ultra. In total, 160 recruited. produced a higher sensitivity (45%, 34 76) than (28%, 21 76; P = 0.001) culture (18%, 14 < 0.001), respectively. Inclusion outcomes increased percentage definite case from 36% (27 51%...
Feline calicivirus (FCV) is a common feline infectious pathogen that mainly causes upper respiratory tract disease. To investigate the prevalence of FCV in Guangdong Province China, total 152 nasal and throat swabs from cats suspected infection were collected veterinary clinics or shelters 2018 to 2022. The positive detection rate was 28.9% (44/152) by RT-PCR. In addition, twenty isolates successfully isolated purified. Eleven out selected for further phylogenetic analyses based on capsid...
Pulmonary tuberculosis caused by Mycobacterium remains a global problem. Inflammatory responses are the primary characteristics of patients with pulmonary in intensive care units (ICU). The aim present study was to investigate clinical importance inflammatory cells and factors for ICU. A total 124 ICU were recruited study. examined changes serum. results indicated that serum levels lymphocytes, plasma cells, granulocytes monocytes increased compared healthy controls. interleukin (IL)-1,...
Unsatisfactory efficacies of currently recommended anti-Mycobacterium abscessus complex (MABC) treatment regimens have led to development novel drugs combat MABC infections. In this study, we evaluated in vitro antimicrobial activities bedaquiline (BDQ) and four oxazolidinones against isolates.The resazurin microplate assay was performed determine minimum inhibitory concentrations (MICs) BDQ oxazolidinones, including tedizolid (TZD), sutezolid (SZD), delpazolid (DZD), linezolid (LZD), 65...
Background Hemorrhagic fever with renal syndrome (HFRS) is an important infectious disease in Hebei Province. At present, cases from the northeast regions of province account for >80% total incidences. However, studies that examine region-specific genetic variations Hantavirus (HV), causative pathogen HFRS, have been lacking. Methods Rodents were collected Province 2004 to 2013, and HV strains used this study isolated 1993. Lung tissues rodents antigen was detected by indirect...
Liver inflammation and macrophage infiltration are critical steps in the progression of non‑alcoholic fatty liver to development steatohepatitis. Bone morphogenetic protein‑9 is a cytokine involved regulation chemokines lipogenesis. However, function bone steatohepatitis still unknown. The present study hypothesized that may contribute mice fed methionine choline deficiency diet (MCD). C57BL/6 overexpressing control were MCD for 4 weeks. tissue serum samples obtained subsequent measurements....
Introduction Brucellosis is a highly prevalent zoonotic disease caused by Brucella spp. suis S2 vaccination an effective strategy to prevent animal brucellosis. However, induces antibodies against the smooth lipopolysaccharide,making it challenging distinguish field infected from vaccinated livestock. Early and accurate diagnosis essential for infection control prevention. In this study, we aimed develop quick assay BrucellaS2 vaccine strain closely related B. abortus melitensis . Methods...
To characterize clinical, computed tomography (CT) and magnetic resonance imaging (MRI) features of tuberculosis (TB) the parotid nodes.CT (n=21) MR (n=7) images, clinical data from 25 patients with TB nodes were retrospectively analyzed by two experienced radiologists who reached consensus.Younger (aged <50 years) accounted for 72%. Eighty percent asymptomatic, had no history exposure. According to findings, 64% 60% misdiagnosed as having tumors, respectively. A total 43 lesions identified....
The diagnosis of tuberculous meningitis (TBM) is difficult due to the lack sensitive methods. Identification TBM-specific biomarkers in cerebrospinal fluid (CSF) may help diagnose and improve our understanding TBM pathogenesis.Of 112 suspected patients with prospectively enrolled study, 32 inconclusive diagnosis, non-infectious meningitis, long-term treatment hormones immunosuppressants were excluded. expression 8 proteins CSF was analyzed using ELISA 22 definite TBM, 18 probable 40...
This study aims to evaluate plasma S100A9 levels in tuberculosis (TB) patients with admission the ICU as a marker predict risk of death for pulmonary severe TB.This enrolled 256 TB admitted Beijing Chest Hospital from Jan Dec 2019. The were measured by ELISA. Standard clinical parameters collected. non-parametric Mann-Whitney test, t-test, and chi-square test applied statistical comparison. A multivariable analysis was performed identify factors death.The higher non-survivors (25.88,...