A5071574426- Tuberculosis Research and Epidemiology
- Immune cells in cancer
- Mycobacterium research and diagnosis
- Infectious Diseases and Mycology
- interferon and immune responses
First Hospital of Shanxi Medical University
2024
Shanxi Medical University
2024
Beijing Chest Hospital
2023
Capital Medical University
2023
Unsatisfactory efficacies of currently recommended anti-Mycobacterium abscessus complex (MABC) treatment regimens have led to development novel drugs combat MABC infections. In this study, we evaluated in vitro antimicrobial activities bedaquiline (BDQ) and four oxazolidinones against isolates.The resazurin microplate assay was performed determine minimum inhibitory concentrations (MICs) BDQ oxazolidinones, including tedizolid (TZD), sutezolid (SZD), delpazolid (DZD), linezolid (LZD), 65...
Background In the fight against tuberculosis, besides chemotherapy, regulation of oxidative stress (OS) has also aroused people’s interest in host-oriented therapy. However, there is limited research on genes involved reactive oxygen species (ROS) production and clearance macrophages infected with Mycobacterium tuberculosis (MTB). This study analyzes explores this to provide a basis for exploring new targets antituberculosis treatments. Methods We established macrophage model MTB, counted...
Introduction: The purpose of this study was to observe the effect N-acetylcysteine (NAC) on oxidative stress (OS), intracellular Mycobacterium tuberculosis (MTB) load, apoptosis, and autophagy macrophages infected with H37Rv MTB. In addition, we explored possible mechanism action, provide a rationale for use NAC in treatment tuberculosis. Methodology: We divided THP-1 into four groups: control, control + NAC, H37Rv, NAC. OS, MTB colony-forming unit (CFU) indexes were measured at 0, 4, 24, 48...