A5075888012- Temporomandibular Joint Disorders
- Facial Nerve Paralysis Treatment and Research
- Reconstructive Surgery and Microvascular Techniques
- Orthodontics and Dentofacial Orthopedics
- Dental Implant Techniques and Outcomes
- Facial Trauma and Fracture Management
- Periodontal Regeneration and Treatments
- Oral and Maxillofacial Pathology
- Bone Tissue Engineering Materials
- Metal and Thin Film Mechanics
- Advanced materials and composites
- Spinal Fractures and Fixation Techniques
- Voice and Speech Disorders
- Orthopaedic implants and arthroplasty
- Dental materials and restorations
- Cleft Lip and Palate Research
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Total Knee Arthroplasty Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Bone Tumor Diagnosis and Treatments
- Myofascial pain diagnosis and treatment
- Silk-based biomaterials and applications
- Diamond and Carbon-based Materials Research
- Osteoarthritis Treatment and Mechanisms
Shanghai Ninth People's Hospital
2015-2025
Shanghai Jiao Tong University
2014-2025
National Clinical Research Center for Digestive Diseases
2018-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
National Clinical Research
2021
Periodontitis is an immune inflammatory disease that leads to progressive destruction of bone and connective tissue, accompanied by the dysfunction even loss periodontal ligament stem cells (PDLSCs). Pyroptosis mediated gasdermin-D (GSDMD) participates in pathogenesis diseases. However, whether pyroptosis mediates PDLSC loss, inflammation triggered involved pathological progression periodontitis remain unclear. Here, we found PDLSCs suffered GSDMD-dependent release interleukin-1β (IL-1β)...
Total temporomandibular joint (TMJ) prosthesis is an effective and reliable method of reconstruction. However, there still urgent need to design a new TMJ because no commercially available appropriate for the clinical application on Chinese population. This study was introduced prospectively confirm safety effectiveness with customized 3D printing additive fabrication in application.Patients unilateral end-stage osteoarthrosis were recruited this from Nov 2016 Mar 2017. Computed tomography...
Guided bone regeneration gathers significant interest in the realm of tissue engineering; however, interplay between membrane thickness and permeability continues to pose a challenge that can be addressed by water-collecting mechanism spider silk, where water droplets efficiently move from smooth filaments rough conical nodules. Inspired natural design an innovative silk fibroin is developed featuring directional fluid transportation via harmoniously integrating smooth, dense layer with...
Abstract Heterotopic ossification (HO) comprises the abnormal formation of ectopic bone in extraskeletal soft tissue. The factors that initiate HO remain elusive. Herein, we found calcified apoptotic vesicles (apoVs) led to increased calcification and stiffness tendon extracellular matrix (ECM), which initiated M2 macrophage polarization progression. Specifically, single‐cell transcriptome analyses different stages revealed apoVs were primarily secreted by a PROCR + fibroblast population. In...
Kaempferide (KF) is an O-methylated flavonol, a natural plant extract, which often found in Kaempferia galanga. It has variety of effects including anti-carcinogenic, anti-inflammatory, anti-oxidant, anti-bacterial and anti-viral properties. In this study, we aimed to investigate whether KF effectively inhibits titanium particle induced calvarial bone loss via down regulation the JNK signaling pathway. mice with osteolysis, Low dose mildly reduced resorption pits while high group, fewer...
Abstract The purpose of this study was to confirm the 5-year efficiency temporomandibular joint (TMJ) anchorage, using clinical evaluation and magnetic resonance imaging (MRI). We also studied influence disc length position on postoperative condylar height. Sixty-one patients (76 joints) undergoing TMJ anchorage were followed up for >5 years. Visual analogue scale (VAS) score maximum mouth-opening pre-and postsurgery analysed patient satisfaction recorded. Disc length, condyle height pre-...
To guide barrier membrane choice in the treatment of peri-implant alveolar bone defects, we evaluated guided regeneration (GBR) using titanium (Ti) mesh or Bio-Gide membrane, independently combination, for repair defects Beagle dogs. Six months after extraction mandibular premolars and first molars from three beagle dogs, inserted implants assigned into 3 groups covered with following combinations: Group A: Implant + Bio-Oss Ti-mesh, B: Bio-Gide, C: Ti-mesh Bio-Gide. At 6 months, micro-CT...
Total joint replacement (TJR) is widely applied as a promising treatment for the reconstruction of serious diseases but usually characterized by critical loss skeletal muscle attachment to metal prostheses, resulting in fibrous scar tissue formation and subsequent motor dysfunction. Tissue engineering technology may provide potential strategy regeneration into prostheses. Here, porous titanium (Ti) alloy scaffold coated with carbon nanotubes (CNTs) mesoporous silica nanoparticles (MSNs)...
The aim of this study was to introduce an improved surgical technique using a pouch design and tension-free wound closure for periodontally accelerated osteogenic orthodontics (PAOO) in the anterior alveolar region mandible. Patients with bone dehiscence fenestrations on buccal surfaces mandible underwent modified PAOO (using closure). Postoperative symptoms were evaluated at 1 2 weeks intervals following procedure. Probing depth (PD), gingival recession (GRD), clinical attachment level...
Recent advances in digital workflow have transformed clinician's ability to offer patient-specific devices for medical and dental applications. However, the of maxillofacial prostheses (MFP) remains incomplete, several steps manufacturing process are still labor-intensive costly both time resources. Despite high demand direct MFP manufacturing, three-dimensional (3D) printing colored silicone is limited by processing routes medical-grade silicones biocompatible elastomers. In this study, a...