A5072664350- Aquaculture disease management and microbiota
- Cerebrovascular and genetic disorders
- Neurological Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Hereditary Neurological Disorders
- Invertebrate Immune Response Mechanisms
- Genetic Neurodegenerative Diseases
- interferon and immune responses
- Mitochondrial Function and Pathology
- Physiological and biochemical adaptations
- Aquaculture Nutrition and Growth
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Barrier Structure and Function Studies
- Porphyrin Metabolism and Disorders
- Calpain Protease Function and Regulation
- Lysosomal Storage Disorders Research
- Machine Learning in Bioinformatics
- Neurological and metabolic disorders
- Identification and Quantification in Food
- Intracerebral and Subarachnoid Hemorrhage Research
- Parkinson's Disease Mechanisms and Treatments
- Metalloenzymes and iron-sulfur proteins
- Moyamoya disease diagnosis and treatment
- Myxozoan Parasites in Aquatic Species
Capital Medical University
2021-2025
Ningbo University
2023-2024
Ministry of Agriculture and Rural Affairs
2023
Institute of Genetics and Developmental Biology
2022
Chinese Academy of Sciences
2022
Southern Medical University
2019
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) heterozygous HTRA1 mutation-related cerebral small vessel disease (CSVD) are the two types of hereditary CSVD. Blood-brain barrier (BBB) failure has been hypothesized in pathophysiology However, it is unclear whether there BBB damage CSVD, especially In this study, a case-control design was used groups including CADASIL (n = 24), CSVD 9) healthy controls 24). All participants underwent...
We explored how blood-brain barrier (BBB) leakage rate of gadolinium chelates (K
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a rare hereditary disease characterized by cerebellar ataxia, pyramidal signs in lower limbs, and sensorimotor neuropathy. The caused bi-allelic mutations the SACS gene encoding sacsin protein. Over 200 have been reported worldwide. Here, we report two unrelated Chinese ARSACS patients with novel revealed whole-exome sequencing (WES). One 36-year-old female patient exhibited classical characteristics including tract limbs...
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a rare hereditary cerebrovascular disease caused by homozygous or compound heterozygous variations in the high-temperature requirement A serine peptidase 1 (HTRA1) gene. However, several studies recent years have found that some HTRA1 mutations also cause cerebral small vessel (CSVD). The current study aims to report novel genotypes, phenotypes, histopathologic results of 3 pedigrees CSVD...
Large yellow croaker ( Larimichthys crocea ), the most developing fish of China, suffering from both biotic and abiotic stressors. A genome-wide study was performed for first time to investigate roles Toll-like receptor genes in large LcTLRs ) working hypoxia response Aeromonas hydrophila infection. 12 TLR were identified annotated, phylogenetic tree, analysis structure motifs demonstrated that TLRs highly conserved. To further under environmental stress, expression pattern hypoxic infection...
<b><i>Background:</i></b> Spinocerebellar ataxia type 12 (SCA12) is a rare SCA subtype with unclear clinical and imaging features. Also, the radiological changes in prodromal early stages remain unknown. <b><i>Methods:</i></b> Ten symptomatic two presymptomatic cases from three Chinese pedigrees received assessments studies including routine magnetic resonance (MRI), diffusion kurtosis (DKI), positron emission tomography (PET) using...
We applied 3D diffusion-prepared pseudo-continuous arterial spin labeling (DP-pCASL) to evaluate water exchange rate (k w ) of blood brain barrier (BBB) and its association with clinical characteristics cerebral autosomal recessive arteriopathy subcortical infarcts leukoencephalopathy (CARASIL) patients. The CARASIL group showed significantly decreased k flow (CBF) compared healthy controls. between age, CBF white matter hyperintensity volumes (WMH) found in patients suggest that could be a...
Large yellow croaker, one of the most economically important marine fish on southeast coast China, suffering from infection bacteria and protozoon, hypoxia, other abiotic stress. The study genes related to immune response will provide new insight into aquaculture under above stressful environment. Toll-like receptors (TLRs) are crucial detectors microbial biomolecules mediators inflammatory pathways in innate fish. This identified a total 12 TLR large croaker (LcTLRs), phylogenetic tree...