A5100649613- Reproductive Biology and Fertility
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Thyroid Disorders and Treatments
- Prenatal Screening and Diagnostics
- Reproductive Health and Technologies
- Thyroid Cancer Diagnosis and Treatment
- Endometriosis Research and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Reproductive System and Pregnancy
- Gestational Trophoblastic Disease Studies
- Ectopic Pregnancy Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Sexual Differentiation and Disorders
- Renin-Angiotensin System Studies
- Vitamin D Research Studies
- Hernia repair and management
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Coronary Interventions and Diagnostics
- Uterine Myomas and Treatments
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
Third Affiliated Hospital of Zhengzhou University
2015-2024
Capital Medical University
2021-2022
Nanjing Medical University
2022
Beijing Anzhen Hospital
2021-2022
Zhengzhou University
2015-2020
Zhengzhou People's Hospital
2017-2018
Shandong Provincial Hospital
2015-2016
Shandong University
2013-2016
Ministry of Education of the People's Republic of China
2015
Sun Yat-sen University
2010-2013
Abstract Background Standard morphologic evaluation has been the most widely adopted approach to embryo selection, and remains common strategy.The objective of study determine association between grading implantation rate euploid blastocysts in single frozen-thawed transfer (SET) cycles. Methods A total 271 patients aged 20–40 years undergoing SET from January 2017 December 2019 were included retrospective cohort . The cycles divided into three groups based on their before cryopreservation:...
Alzheimer's disease (AD) is a serious, common, global disease, yet its etiology and pathogenesis are incompletely understood. Although an association between AD exposure to air pollutants has been discussed, the effects of on functioning brain remain unclear. The indoor environment where formaldehyde (FA) can occur. Whether FA contributes development needs be investigated. To determine objective, C57BL/6 mice were exposed daily (0, 0.155, 1.55 15.5 mg/kg/day) for 1 week. After acute...
This study investigated the risk factors and early predictors for heterotopic pregnancy (HP) after in vitro fertilization embryo transfer (IVF-ET). From January 2008 to 2013, 41 cases of HP 72 intrauterine twin IVF-ET were recruited retrospectively analyzed. Compared with group, group had a lower basal luteinizing hormone (LH) level (P = 0.005) more history hydrosalpinx 0.008). After 14 days IVF-ET, serum β-HCG (β-human chorionic gonadotropin), E2 (Estradiol) P (Progesterone) levels...
Background: Homocysteine (Hcy) plays an important role in vascular function and Hcy level contributes to pathogenesis of ischemic stroke (IS). MTHFR gene polymorphism may have effects on IS risks by influencing the metabolic pathway. In present study, a case–control study was designed evaluate relationship among C677Tpolymorphism, plasma level, susceptibility Chinese population. Methods: A total 300 patients with 261 matched control subjects were recruited. Plasma concentration determined...
The aim of this study was to investigate whether blastocyst morphology and developmental rate are associated with euploidy live birth rates (LBRs) in single euploid frozen-thawed embryo transfer (FET) cycles.Retrospective cohort study.This included 431 preimplantation genetic testing for aneuploidy (PGT-A) cycles followed by 393 FET performed at our center from June 2017 March 2021. All were analyzed based on (good, average poor), stage (day 5 6) maternal age (< 35 ≥ years old). Multivariate...
Abstract Stathmin 1 (STMN1) is a biomarker in several types of neoplasms. It plays an important role cell cycle progression, mitosis, signal transduction and migration. In ovaries, STMN1 predominantly expressed granulosa cells (GCs). However, little known about the ovary. this study, we demonstrated that overexpressed GCs patients with polycystic ovary syndrome (PCOS). mouse primary GCs, overexpression stimulated progesterone production, whereas knockdown decreased production. We also found...
The present study investigated the role of β-hCG in predicting reproductive outcomes and established optimal cutoff values women undergoing cleavage embryo transfer.The patients were transferred with fresh or frozen-thawed embryos had serum levels tested on 14th day post-embryo transfer. Serum compared between different groups. Different used to divide into Reproductive groups based compared.Significant discrepancies general characteristics observed subgroups. for presence/absence pregnancy,...
Objective. The guidelines of the American Thyroid Association (ATA) recommend an upper limit reference interval (RI) thyroid stimulating hormone (TSH) 2.5 mIU/L in first trimester pregnancy and 3.0 subsequent trimesters, but some reported ranges China are significantly higher. Our study aimed to establish trimester- assay-specific RIs for hormones normal pregnant Chinese women. Methods. In this cross-sectional study, 2540 women with pregnancies (first trimester, n = 398; second 797; third...
To compare the clinical outcomes of dydrogesterone (DYG) and medroxyprogesterone (MPA) in progestin-primed ovarian stimulation (PPOS) protocol for patients with poor response (POR).This was a retrospective cohort study. Women POR who underwent IVF/ICSI at Reproductive Center Third Affiliated Hospital Zhengzhou University between January 2020 2021 were included. The primary outcome measure our study number oocytes retrieved. secondary measures present 2PN, available embryos, oocyte retrieval...
Abstract Immunophenotyping of blood lymphocytes has become an important tool in the diagnosis immunologic and hematologic disorders such as immunodeficiencies, lymphoproliferative autoimmune diseases. Lymphocyte subsets include total T‐cells (CD3 + ), TH (T helper, CD3 CD4 TC (cytotoxic T cells, CD8 B‐cells − CD19 NK‐cells CD16 CD56 ). Specific lymphocyte subset reference intervals should be locally established for meaningful comparison to obtain accurate interpretation results. Reference...
No coding sequence variants of the gene encoding 5-lipoxygenase-activating protein (ALOX5AP) leading to amino acid substitutions have been identified. Therefore, in ALOX5AP promoter region received attention recently. The purpose this study was explore whether polymorphism rs17222919 is involved etiology ischemic stroke (IS) Chinese Han population. We investigated by TaqMan genotyping two independent samples: first comprised 910 IS patients and 925 healthy inhabitants from northern Henan...
The pathological process of atopic dermatitis (AD) progressing into other types allergic diseases such as asthma and rhinitis during the first several years life is often referred to march. Although phenomenon march has been recognized for decades, how stems from AD still not fully understood, confounding a universal strategy effectively protect people
Abstract Background Growth hormone (GH) and insulin signaling pathways are known important regulators of adipose homeostasis. The cross-talk between GH in mature adipocytes is poorly understood. Methods In the present study, impact on GH-mediated differentiated 3T3-F442A primary mice was examined. Results Insulin alone did not induce STAT5 tyrosine phosphorylation, but enhanced GH-induced activation. This effect more pronounced when added 20 min prior to treatment. above results were further...
Abstract Background Previous studies have reported that after laparoscopic cystectomy of ovarial endometrioma, the ovarian response to gonadotropin (Gn) significantly decreased. However, for patients with diminished reserve (DOR) surgery, how choose most appropriate controlled hyperstimulation protocol has not been concluded. Compared traditional agonist regimen, (Gn)-releasing hormone (GnRH) antagonist, microstimulation, and progestin-primed stimulation (PPOS) protocols are simple operate a...
Abstract Background To analyze the characteristics of basal thyroid hormone levels in infertile women consulting for assisted reproductive technology (ART) treatment. Methods This was a retrospective study. Serum TSH, FT3 and FT4 seeking ART consultation were tested routinely. Analyses performed based on age sampling time. One-way ANOVA or Kruskal-Wallis rank sum test used to compare continuous data among groups, chi-square Fisher’s exact categorical where appropriate. Results A total 6426...
Objective This study aimed to determine whether controlled ovarian hyperstimulation (COH) parameters influence the incidence of de novo chromosomal abnormalities (&gt; 4 Mb) in blastocysts and, thus, clinical pregnancy outcomes preimplantation genetic testing (PGT). Methods Couples who underwent for structural chromosome rearrangements (PGT-SR) and monogenic disorders (PGT-M) were included this study. The relationships maternal age, paternal stimulation protocol, exogenous gonadotropin...
Abstract The aim of the study is to compare outcomes between insemination methods conventional in vitro fertilization and intracytoplasmic sperm injection infertile women with thyroid autoimmunity non-male factor infertility. This was a retrospective cohort which included Reproductive such as embryo development parameters clinical were compared two groups. propensity score matching applied balance general characteristics significant differences Generalized estimating equations used explore...
In-stent chronic total occlusion (IS-CTO) represents a unique challenge for percutaneous coronary intervention. Whether the optimal treatment IS-CTO is angioplasty with paclitaxel-coated balloons (PCBs) or repeat stenting drug-eluting stents (DESs) unclear. We aimed to evaluate long-term clinical outcome of PCB and DES IS-CTO.We retrospectively included patients who underwent successful from January 2016 December 2019. The primary endpoints were major adverse cardiac events (MACEs),...
Abstract Background The aim of this study was to investigate the impact TSH levels on clinical outcomes 14 days after frozen-thawed embryo transfer. Methods Blood samples were collected first visit our department and Women divided into three groups based D14 levels, which compared basal in with different outcomes. between pregnant nonpregnant women also compared. Results pregnancy rate lower transfer slightly but significantly (56%, P = 0.05) those higher levels. Furthermore, elevated who...
To evaluate the impact of preconceptional serum TSH levels on clinical outcomes infertile patients undergoing their first IUI treatment cycle.This was a retrospective study. Euthyroid cycle from Jan 2017 to Aug 2018 were included. The divided into normal high level (2.5-4.0 mIU/L) group and low (0.4-2.5 group. Then, different factors included separately compare between levels. primary pregnancy rates, implantation miscarriage rates. secondary obstetric such as single live birth length,...