A5100368039- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Biology and Fertility
- Renal and related cancers
- Genomic variations and chromosomal abnormalities
- Genetic Syndromes and Imprinting
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy and preeclampsia studies
- Parvovirus B19 Infection Studies
- Reproductive Health and Technologies
- Vascular Anomalies and Treatments
- Organ and Tissue Transplantation Research
- Endometriosis Research and Treatment
- Ovarian function and disorders
- Cancer Genomics and Diagnostics
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Molecular Biology Techniques and Applications
- Disability Rights and Representation
- Maternal and fetal healthcare
- Fetal and Pediatric Neurological Disorders
- Air Quality and Health Impacts
Lanzhou University Second Hospital
2025
Lanzhou University
2025
Northwest Women's and Children's Hospital
2024
Third Affiliated Hospital of Zhengzhou University
2020-2023
Cangzhou Central Hospital
2021
Second Hospital of Anhui Medical University
2021
Anhui Medical University
2021
Zhengzhou University
2020
Changzhi Medical College
2020
Fudan University
2019
Abstract Purpose To investigate the associations between blastocyst development and sex ratio (male:female) among singleton live births resulting from single-blastocyst frozen embryo transfer (FET) cycles. Methods Patients with following first autologous single FET of non- preimplantation genetic testing (PGT) blastocysts in a reproductive medicine department January 2015 February 2019 were included this retrospective study. The primary outcome measure was ratio. Multivariable logistic...
Background One potential cause of implantation failure is abnormal endometrial receptivity, and how to objectively evaluate receptivity has been a matter great concern. Endometrial analysis (ERA), next-generation sequencing-based test that assesses gene expression, may be valuable in predicting but whether ERA improves pregnancy outcomes patients with recurrent (RIF) currently controversial. The purpose this study was investigate the effect on RIF. Methods We performed retrospective cohort...
Chromosome aneuploidies commonly arise in embryos produced by assisted reproductive technologies and represent a major cause of implantation failure miscarriage. Currently, preimplantation genetic diagnosis (PGD) is performed array-based methods to identify euploid for transfer the patient. We speculated that combination next-generation sequencing sophisticated bioinformatics would deliver more comprehensive accurate methodology improve overall efficacy embryo testing. To meet this...
The aim of this study was to investigate whether blastocyst morphology and developmental rate are associated with euploidy live birth rates (LBRs) in single euploid frozen-thawed embryo transfer (FET) cycles.Retrospective cohort study.This included 431 preimplantation genetic testing for aneuploidy (PGT-A) cycles followed by 393 FET performed at our center from June 2017 March 2021. All were analyzed based on (good, average poor), stage (day 5 6) maternal age (< 35 ≥ years old). Multivariate...
A couple with a proband child of GJB2 (encoding the gap junction protein connexin 26)-associated hearing impairment and previous pregnancy miscarriage sought for reproductive solution to bear healthy child. Our study aimed develop customized preconception-to-neonate care trajectory fulfill this clinical demand by integrating preimplantation genetic diagnosis (PGD), noninvasive prenatal testing (NIPT), (NIPD) into strategy. Auditory was carried out identify disease causative mutations. The...
Objective To determine whether preimplantation genetic testing for aneuploidy (PGT-A) can improve the pregnancy outcomes of patients aged under 38 years who have a history recurrent implantation failure(RIF). Design Retrospective cohort study. Methods We retrospectively studied RIF from January 2017 to December 2021.178 were divided into two groups according they underwent PGT-A: PGT-A group(n=59)and control group(n=119).In group, we compared euploidy rate different quality and developmental...
Abstract Objectives There is little evidence in China regarding the cost-effectiveness of non-invasive prenatal testing (NIPT) for Down syndrome (DS). This study aims to evaluate NIPT and provide inform decision-making. Methods To determine DS, a decision-analytic model was developed using TreeAge Pro software from societal perspective simulated cohort 10 000 pregnant women. Main indicators were based on field surveys sampled hospitals four locations literature review. Results The...
This study was designed to explore the expression and diagnostic value of vascular endothelial growth factor (VEGF) soluble fms-like tyrosine kinase-1 (sFlt-1) in pernicious placenta previa (PPP) combined placental accreta/increta. A total 140 PPP patients were enrolled divided into two groups: 56 with accreta/increta (PA group), 84 without (non-PA group). In same period, 46 pregnant women who had undergone caesarean section selected as controls. The levels VEGF sFlt-1 serum detected by...
Cooking oil fume (COF) is an important source of indoor air pollution which severely affects human health, and sufficient vitamin D3 (VitD3) necessary for maternal child health. However, the effects cooking fume-derived PM2.5 (COF-PM2.5) on birth outcomes whether VitD3 could protect from adverse caused by COFs-PM2.5 are still unclear.Twenty-four pregnant rats were divided into 4 groups treated with various treatments: normal feeding, intratracheal instillation, intragastric administration,...
Introduction In the realm of natural frozen-thawed embryo transfer (FET) cycles, application luteal phase support (LPS) is a prevalent practice, primarily due to its beneficial impact on reproductive outcomes. Among various LPS medications, human chorionic gonadotropin (hCG) one that exerts function both corpus luteum and endometrium. Objective To evaluate effect hCG administration as outcomes in FET cycles. Methods This study was retrospective cohort analysis conducted at tertiary care...
Abstract Objective To determine whether the morphologic parameters of euploid blastocyst influence live birth rate (LBR) following single frozen-thawed embryo transfer (FET) cycles? Methods A retrospective cohort analysis involving autologous FET cycles after next generation sequencing (NGS) based preimplantation genetic testing for aneuploidy (PGT-A) by a large in vitro fertilization (IVF) center that was performed from June 2017 to September 2019.Women were divided into three age groups...
Abstract Objectives: Polycystic kidney disease (PKD) is a common autosomal monogenic genetic disease. PKD1 mutation accounts for about 85% of ADPKD patients. Pre-implantation testing-M (PGT-M monogenic) an important approach to prevent the transmission diseases from parents offspring. Design: In this study, We have identified family linkage and site in embryos with NGS-based SNP phasing Sanger Sequencing. Methods: Multiple Annealing Looping Based Amplification Cycles (MALBAC) method was...
Abstract Background: The aim of this study was to investigate whether the morphologic parameters euploid blastocyst influence live birth rate (LBR) following single frozen-thawed embryo transfer (FET) cycles? Methods: Women who undergone first preimplantation genetic testing for aneuploidy (PGT-A) and received FET cycles from June 2017 September 2019 were divided into three age groups (<30, 30-34 ≥35 years). primary outcome measure LBR. Outcomes compared determine association among...
Abstract Background The aim of this study was to investigate whether the morphologic parameters blastocyst influence live birth rate (LBR) euploid embryos transferred in subsequent single frozen-thawed embryo transfer (FET) cycles? Methods Women who received first preimplantation genetic testing for aneuploidy (PGT-A) and following underwent cycles from June 2017 May 2020 were divided into three age groups (< 30, 30–34 ≥ 35 years). primary outcome measure LBR. Outcomes compared between...
Abstract Objective To investigate whether the morphologic parameters of euploid blastocyst influence live birth rate (LBR) following single frozen-thawed embryo transfer (FET) cycles? Methods A retrospective cohort analysis involving autologous FET cycles after preimplantation genetic testing for aneuploidy (PGT-A) through next generation sequencing (NGS) by a university-based reproductive medical center that was performed from June 2017 to September 2019.Women were divided into three age...