A5061909555- Computational Drug Discovery Methods
- Cancer therapeutics and mechanisms
- Organic and Inorganic Chemical Reactions
- Recycling and Waste Management Techniques
- Water Quality Monitoring and Analysis
- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Advanced oxidation water treatment
- Catalytic C–H Functionalization Methods
- Water Quality and Pollution Assessment
- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Quinazolinone synthesis and applications
- Pharmacogenetics and Drug Metabolism
- Environmental Quality and Pollution
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Synthetic Organic Chemistry
- Electrochemical Analysis and Applications
- Covalent Organic Framework Applications
- Catalytic Cross-Coupling Reactions
- Alkaloids: synthesis and pharmacology
- Analytical chemistry methods development
- Marine and coastal ecosystems
- Berberine and alkaloids research
- Heavy metals in environment
Jilin Normal University
2024
Nanjing University of Information Science and Technology
2024
Innovation Team (China)
2023
Shaanxi University of Science and Technology
2021-2023
University of British Columbia
2011-2013
Shanghai University of Engineering Science
2012-2013
Jiangsu University of Technology
2010
Here we report a novel Rh-catalyzed C−H/C−H alkenylation of N-arylmethanimines with vinylene carbonate acting as unit. Forty examples C3,C4-nonsubstituted quinolines were achieved from commercially available starting materials. This identified process features an exceedingly simple system, lower loading catalyst, and the capacity for postfunctionalization bioactive molecules.
The Pictet-Spenglerase strictosidine synthase (STR1) has been recognized as a key enzyme in the biosynthesis of some 2000 indole alkaloids plants, with high therapeutic value. In this study, novel function STR1 detected which allows for first time simple enzymatic synthesis analogue 3 harboring piperazino[1,2-a]indole (PI) scaffold and to switch from common tryptoline (hydrogenated carboline) rare PI skeleton. Insight into reaction is provided by X-ray crystal analysis modeling ligand...
Androgen receptor (AR) plays a critical role in the development and progression of prostate cancer (PCa). The AR hormone-binding site (HBS) is intensively studied represents target area for current antiandrogens including Bicalutamide structurally related Enzalutamide. As resistance to invariably emerges advanced cancer, there exists high medical need identification novel antagonists different chemotypes. Given wealth structural information on complex with variety ligands, we have applied an...
Direct functionalization of the C(O)-N amide bond is one most high-profile research directions in last few decades; however oxidative couplings involving bonds and thioamide C(S)-N analogues remain an unsolved challenge. Herein, a novel hypervalent iodine-induced twofold coupling amines with amides thioamides has been established. The protocol accomplishes divergent disconnection by previously unknown Ar-O Ar-S highly chemoselectively assembles versatile yet synthetically challenging...
The recent widespread use of microplastics (MPs), especially in pharmaceuticals and personal care products (PPCPs), has caused significant water pollution.
Two novel thiophene-based COFs were prepared for the adsorption of I 2 vapor and amounts 4.67 2.47 g −1 respectively.
A practical and straightforward approach for the highly stereoselective synthesis of γ,δ-unsaturated β-amino sulfones by nucleophilic (phenylsulfonyl)methylation <i>N</i>-<i>tert</i>-butylsulfinyl ketimines with methyl phenyl sulfone was achieved. With lithium bis(trimethylsilyl)amide as base, corresponding sulfone-stabilized carbanion derived from can be transferred to (<i>S</i>)-α,β-unsaturated in very good yields high diastereoselectivities. Electron-withdrawing or electron-donating...
The vertical distribution of the marine total suspended matter (TSM) concentration significantly influences material transport, sedimentation processes, and biogeochemical cycles. Traditional field observations are constrained by limited spatial temporal coverage, necessitating use remote-sensing technology to comprehensively understand TSM variations over extensive areas periods. This study proposes a approach estimate concentrations using MODIS satellite data, with Bohai Sea Yellow (BSYS)...
Shallow groundwater was sampled from 45 monitoring points in Suzhou area along Kuihe River, China, and organic pollutants including volatile compounds, semi-volatile compounds organophosphorus pesticide the water were tested with GC/MS, HPLC GC/ECD. Seven detected among 82 substances. In pollutants, Phenanthrene, Naphthalene di-2-ethylhexyl phthalate widely detected, but Dichloromethane Malathion only partial sampling points. The concentrations of four higher than Limits for Drinking Water...
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Scaffold Tailoring by Newly Detected Pictet–Spenglerase Activity of Strictosidine Synthase: From the Common Tryptoline Skeleton Rare Piperazino-indole FrameworkFangrui Wu, Huajian Zhu, Lianli Sun, Chitra Rajendran, Meitian Wang, Xin Ren, Santosh Panjikar, Artem Cherkasov, Hongbin Zou*, and Joachim Stöckigt*Cite this: J. Am. Chem. Soc. 2012, 134, 12, 5716Publication Date (Web):March...
Abstract A convenient procedure is presented for the base‐mediated addition of sulfone (II) to optically active ketimines produce title compounds (III) with high diastereoselectivity.
In order to study the distribution and origin of Cr Ni in shallow groundwater Yongqiao area along Kuihe River, we sampled from both sides Rive Suzhou Anhui province, China. The results showed that a large was polluted by heavy metals this region. Along river direction, concentrations increased gradually, were high middle reach River. region near higher than far river. metal somewhere abnormal. Further analysis indicates characteristic mainly influenced geological condition, surface water...