A5100334162- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Mathematical Biology Tumor Growth
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Genomics, phytochemicals, and oxidative stress
- Ginger and Zingiberaceae research
- Nanoparticle-Based Drug Delivery
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- RNA Research and Splicing
- Inflammatory Bowel Disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Pharmacological Effects of Natural Compounds
- Drug Transport and Resistance Mechanisms
- Modular Robots and Swarm Intelligence
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Hormonal Regulation and Hypertension
Jiangsu Province Hospital
2021-2024
Nanjing Medical University
2021-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Wenzhou Medical University
2024
Southern Medical University
2023
Harbin Medical University
2014-2023
Jiangxi University of Traditional Chinese Medicine
2023
First People's Hospital of Foshan
2023
Nanfang Hospital
2023
Second Affiliated Hospital of Harbin Medical University
2023
Motor neuron death is supposed to result in primary motor cortex atrophy after spinal cord injury (SCI), which relevant poorer recovery for patients with SCI. However, the exact mechanisms of remain elusive. Here, we demonstrated that iron deposition was significantly increased both SCI and rats, triggered accumulation lipid reactive oxygen species (ROS) resulted neuronal ferroptosis ultimately. While chelator, ROS inhibitor reduced overload-induced promoted functional recovery. Further,...
Ferroptosis is a form of iron-dependent programmed cell death that differs from apoptosis with regards to both mechanism and morphology. Therefore, ferroptotic-based cancer therapy has shown significant potential overcome the weaknesses conventional therapeutics mediated by pathways. Effective ferroptosis can be induced intracellular Fenton reaction dependent on adequate supply iron ions H
Nobiletin (NOB), a plant-based polymethoxyflavone, is promising protective agent against sepsis; yet the mechanisms were not fully elucidated. The gut microbiota found to be strongly associated with sepsis-associated acute liver injury (SALI). Here, our study aimed evaluate effect of NOB on SALI and explore underlying molecular mechanisms. Cecal ligation puncture (CLP) was used induce in mice. administered by gavage for 7 days before CLP induction. 16S rRNA gene sequencing fecal...
Prostate cancer is the most commonly diagnosed type of and second leading cause cancer‑associated mortality in males. The efficacy prostate chemotherapy frequently impaired by drug resistance; however, underlying mechanisms this resistance remain elusive. Sex determining region Y-box 2 (Sox2) vital importance regulation stem cell proliferation carcinogenesis. In present study, using MTT, clone formation, cycle apoptosis assays, over-expression Sox2 was demonstrated to enhance paclitaxel...
Intracerebral hemorrhage (ICH) is classified as a lethal neurological injury associated with cerebrovascular disorders. Ferroptosis unique form of cell death and participates in ICH pathogenesis. Herein, the role SRY-box transcription factor 10 (SOX10) ferroptosis hippocampal neurons after was investigated. The vitro models were established by treating immortalized mouse line HT-22 Hemin. Quantitative real-time polymerase chain reaction Western blotting revealed that SOX10 microRNA...
<title>Abstract</title> Background The significance of tumor-secreted cytokines in tumor development has gained substantial attention. Nevertheless, the precise role tumor-related inflammatory prostate cancer (PCa) remains ambiguous. Objectives To gain deeper insights into response process PCa. Methods A total 141 cases were collected, including 70 hyperplasia and 9 prostatitis as disease control, 41 postoperative 21 PCa group. Additionally, 31 patients undergoing physical examinations...
<abstract> <sec><title>Objective</title> Although multiple hub genes have been identified in head and neck squamous cell cancer (HNSCC) recent years, because of the limited sample size inconsistent bioinformatics analysis methods, results are not reliable. Therefore, it is urgent to use reliable algorithms find new prognostic markers HNSCC. </sec> <sec><title>Method</title> The Robust Rank Aggregation (RRA) method was used integrate 8 microarray datasets HNSCC downloaded from Gene Expression...
Abstract Background Nobiletin (NOB), a plant-based polymethoxyflavone, has been shown to be promising protective agent against sepsis; yet the mechanisms were not fully elucidated. The gut microbiota is found strongly associated with sepsis-associated acute liver injury (SALI). Here, our study aimed determine whether these effects of NOB SALI related modulations in microbiota. Methods Cecal ligation and puncture (CLP) was used induce mice. therapy by gavage (50 mg/kg/day) administrated for 7...
Abstract Background The origin recognition complex 1 (ORC1) is a large subunit of the and acts as master precoding complex. Objective To explore potential function clinical significance ORC1 in cancers. Methods expression level different types tumor tissues matched normal were detected by Cancer Genome Atlas (TCGA) validated datasets from gene omnibus (GEO) database. association between infiltration levels immune cell was analyzed. its co-expression genes subjected to enrichment analysis...
Abstract Background The origin recognition complex 1 (ORC1) is a large subunit of the and acts as master precoding complex. Objective To explore potential function clinical significance ORC1 in cancers. Methods expression level different types tumor tissues matched normal were detected by Cancer Genome Atlas (TCGA) validated datasets from gene omnibus (GEO) database. association between infiltration levels immune cell was analyzed. its co-expression genes subjected to enrichment analysis...
Abstract Background: Hepatocellular carcinoma (HCC) remains a growing threat to global health. Necroptosis is newly discovered regulated cell necrosis that plays vital role in cancer development. Thus, we conducted this study develop predictive signature based on necroptosis-related genes. Methods: The tumor samples Cancer Genome Atlas (TCGA) Liver Carcinoma (LIHC) cohort were subtyped using the consensus clustering algorithm. Univariate Cox regression and LASSO-Cox analysis performed...