A5107980616- Functional Brain Connectivity Studies
- Spinal Cord Injury Research
- Transcranial Magnetic Stimulation Studies
- Obsessive-Compulsive Spectrum Disorders
- Memory and Neural Mechanisms
- Vagus Nerve Stimulation Research
- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Stroke Rehabilitation and Recovery
- Heart Rate Variability and Autonomic Control
- Wound Healing and Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural dynamics and brain function
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
- Power Systems and Technologies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Clinical Nutrition and Gastroenterology
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Photoacoustic and Ultrasonic Imaging
- Neuroscience of respiration and sleep
Southwest Hospital
2013-2024
Army Medical University
2013-2024
Motor neuron death is supposed to result in primary motor cortex atrophy after spinal cord injury (SCI), which relevant poorer recovery for patients with SCI. However, the exact mechanisms of remain elusive. Here, we demonstrated that iron deposition was significantly increased both SCI and rats, triggered accumulation lipid reactive oxygen species (ROS) resulted neuronal ferroptosis ultimately. While chelator, ROS inhibitor reduced overload-induced promoted functional recovery. Further,...
As the first inflammatory cell recruited to site of spinal cord injury (SCI), neutrophils were reported be detrimental SCI. However, precise mechanisms as how exacerbate SCI remain largely obscure. In present study, we demonstrated that infiltrated produce neutrophil extracellular traps (NETs), which subsequently promote neuroinflammation and blood-spinal barrier disruption aggravate edema neuronal apoptosis following in rats. Both inhibition NETs formation by peptidylarginine deiminase 4...
Background Spinal cord injury (SCI) is a devastating disease that lacks effective treatment. Interestingly, recent studies indicated vagus nerve stimulation (VNS), neuromodulation widely used in variety of central nervous system (CNS) diseases, improved motor function recovery after SCI. But the exact underlying mechanism how VNS ameliorates SCI unclear. This study aimed to confirm efficacy and further explore potential therapeutic Method A T10 spinal compression model was established adult...
Background Previous studies have demonstrated that structural deficits and functional connectivity imbalances might underlie the pathophysiology of obsessive-compulsive disorder (OCD). The purpose present study was to investigate gray matter abnormal resting-state networks in patients with OCD further association between anatomic alterations clinical symptoms. Methods Participants were 33 treatment-naïve matched healthy controls. Voxel-based morphometry used regions abnormalities analysis...
Cerebral involvement is common in patients with systemic Lupus erythematosus (SLE) and characterized by multiple clinical presentations, including cognitive disorders, headaches, syncope. Several neuroimaging studies have demonstrated cerebral dysfunction during different tasks among SLE patients; however, there been few designed to characterize network alterations or identify markers capable of reflecting the patients. This study was profile activation area functional connectivity function...
The cerebellum is involved in the control and coordination of movements but it remains unclear whether stimulation could improve recovery upper limb motor function. Therefore, this study aimed to explore cerebellar transcranial direct current (tDCS) therapy promote function patients who suffered a stroke.In randomized, double-blind, sham-controlled prospective study, 77 stroke were recruited randomly assigned tDCS group (n = 39) or 38). received anodal (2 mA, 20 min) sham for 4 weeks....
Abstract Background The breakdown of intestinal barrier integrity occurs after severe burn injury and is responsible for the subsequent reactions inflammation oxidative stress. A new protective strategy urgently needed due to limitations traditional methods. Recently, application nanoparticles has become one promising therapies many inflammation-related diseases or damage. Herein, we developed a anti-inflammatory antioxidant nanoparticle named luminol-conjugated cyclodextrin (LCD) aimed...
Although spinal cord injury (SCI) is the main cause of disability worldwide, there still no definite and effective treatment method for this condition. Our previous clinical trials confirmed that increased excitability motor cortex was related to functional prognosis patients with SCI. However, it remains unclear which cell types in lead later recovery. Herein, we applied optogenetic technology selectively activate glutamate neurons primary explore whether activation can promote recovery...
Neuropathic pain is a common complication after spinal cord injury (SCI). Transcranial direct current stimulation (tDCS) has been confirmed to be effective in relieving neuropathic patients with SCI. The aim of this study investigate the effect tDCS on induced by SCI and its underlying mechanism.The model was clip-compression performed for two courses (5 days/each). motor function evaluated Basso-Beattie-Bresnahan (BBB) score, thermal withdrawal threshold radiation method. effects cerebral...
Although mycophenolate mofetil-induced (MMF) effectively improves long-term graft survival, the gastrointestinal (GI) side effects due to MMF-induced GI barrier damage limit its use in clinic. Keratinocyte growth factor (KGF) plays a crucial role intestinal protection and repair process. This study is designed investigate protective effect of KGF on mucosal disruption potential mechanism. Thirty adult male C57BL/6 mice were assigned one following groups: MMF group, + control group (n = 10...
Abstract It has been well established that the cerebellum and its associated circuitry constitute essential neuronal system for both delay trace classical eyeblink conditioning (DEC TEC). However, whether is sufficient to independently modulate DEC, TEC with a shorter interval remained controversial. Here, we used direct optogenetic stimulation of mossy fibers in middle cerebellar peduncle (MCP) as conditioned stimulus (CS) replacement peripheral CS (eg, tone or light CS) paired periorbital...
The aim of the present study was to determine whether amyloid-β (Aβ) protein could be detected in serum and cerebrospinal fluid (CSF) rats with traumatic spinal cord injury (SCI) Aβ levels CSF correlated severity. A total 140 adult female Sprague‑Dawley were randomly divided into four groups: Sham, mild injury, moderate severe injury. Serum samples collected at 12 h, 1, 3, 7, 14, 21 28 days post‑injury. ELISA analysis for performed. Locomotor function all animals assessed using Basso,...
Objective: Finger movement at different strength levels have effects on the brain and muscles, corticomuscular fusion by an effective method has exciting potential for brain-apparatus conversation analysis of multi-source signals.Approach. By performing coherence analysis, electroencephalogram (EEG) electromyogram (EMG) networks, as well network (CMCN), were constructed respectively. Thereafter, we designed a supervised learning structure to refine inherent discriminative spatial information...