A5100325137- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Glaucoma and retinal disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Blood Pressure and Hypertension Studies
- Nosocomial Infections in ICU
- Ophthalmology and Visual Impairment Studies
- Retinal Diseases and Treatments
- Stroke Rehabilitation and Recovery
- Anesthesia and Sedative Agents
- Cardiovascular and exercise physiology
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Cerebrospinal fluid and hydrocephalus
- Sexual function and dysfunction studies
- Transcranial Magnetic Stimulation Studies
- Pneumonia and Respiratory Infections
- Infant Nutrition and Health
- Physical Activity and Health
- Corneal surgery and disorders
Fujian Medical University
2014-2025
Fujian Provincial Hospital
2015-2025
Fuzhou University
2024-2025
University of Massachusetts Amherst
2024
Second Affiliated Hospital of Zhejiang University
2021-2024
Eye & ENT Hospital of Fudan University
2022-2023
Army Medical University
2023
Southwest Hospital
2023
Xuzhou Medical College
2023
Valdosta State University
2023
There is increasing evidence indicating the critical role of ammonia (NH3) in formation secondary aerosols. Therefore, high quality NH3 emission inventory important for modeling particulate matter atmosphere. Unfortunately, without directly measured factors (EFs) developing countries, using data from developed countries could result an underestimation these emissions. A series newly reported EFs China provide opportunity to update inventory. In addition, a recently released fuel consumption...
Rationale: The physiological basis of lung protection and the impact positive end-expiratory pressure (PEEP) during pronation in acute respiratory distress syndrome are not fully elucidated. Objectives: To compare pleural (Ppl) gradient, ventilation distribution, regional compliance between dependent nondependent lungs, investigate effect PEEP supination pronation. Methods: We used a two-hit model injury (saline lavage high-volume ventilation) 14 mechanically ventilated pigs studied supine...
Infections identified between 1981 and 1983 in a hospital's medical/surgical, pediatric, neonatal, coronary care, cardiac surgery ICUs were compared. Among 14,360 admissions, 1840 infections occurred 1360 patients. Total infection rates ranged from 1.0% (cardiac ICU) to 23.5% (medical/surgical ICU). Rates of ICU-acquired 0.8% 11.2% ICU), indicating that only about half the latter unit acquired within. Primary bacteremias comprised 14.5% neonatal ICU infections, rate 500% higher than other...
Objective— Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression CatK in human abdominal aortic aneurysm (AAA) lesions. Whether this protease participates directly AAA formation, however, remains unknown. Methods and Results— Mouse experimental was induced with perfusion a porcine pancreatic elastase. Using model, we demonstrated that absence prevented formation mice 14 days postperfusion. deficiency significantly reduced lesion CD4 +...
Objective Early prediction of long-term outcomes in patients with systemic lupus erythematosus (SLE) remains a great challenge clinical practice. Our study aims to develop and validate predictive models for the mortality risk. Methods This observational identified SLE requiring hospital admission from Medical Information Mart Intensive Care (MIMIC-IV) database. We downloaded data Fujian Provincial Hospital as an external validation set. Variable selection was performed using Least Absolute...
Purpose This study aimed to compare the performance of lactate and CO 2 -derived parameters in predicting major postoperative complications (MPC) after cardiac surgery with cardiopulmonary bypass. Methods Lactate parameters, including venous-arterial difference partial pressure (Pv-aCO ), arterial-venous O content ratio /Ca-vO (Cv-aCO ) at ICU admission, 3 h, 6 12 h later were collected. Receiver-operating characteristics (ROC) curve analysis was carried out assess predictive performance....
BACKGROUND: Excessively deep sedation is prevalent in mechanically ventilated patients and often considered suboptimal. We hypothesized that the bispectral index (BIS), a quantified electroencephalogram instrument, would accurately detect levels of sedation. METHODS: prospectively enrolled 90 critically ill who were receiving The BIS was monitored for 24 hours compared with Richmond Agitation Sedation Scale (RASS) evaluated every 4 hours. Deep defined as RASS −3 to −5. Threshold values...
To evaluate the clinical and genetic virulence characteristics of critically ill patients with hypervirulent Klebsiella pneumoniae (hvKP) classic KP (cKP) infection.The included in this retrospective study (n = 225) were grouped according to their hvKP 114) or cKP 111) status, analysed compared. Cox multivariate analysis was conducted determine risk factors for infection. Length hospital stay, length intensive care unit duration mechanical ventilation 28-day survival rate similar between...
Acute kidney injury (AKI) frequently emerges as a consequential non-neurological sequel to traumatic brain (TBI), significantly contributing heightened mortality risks. The intricate interplay of oxidative stress in the pathophysiology TBI underscores centrality Keap1-Nrf2/HO-1 signaling pathway pivotal regulator this context. This study endeavors elucidate involvement modulating AKI subsequent and concurrently explore therapeutic efficacy dimethyl fumarate (DMF). A rat model was established...
The cerebellum is involved in the control and coordination of movements but it remains unclear whether stimulation could improve recovery upper limb motor function. Therefore, this study aimed to explore cerebellar transcranial direct current (tDCS) therapy promote function patients who suffered a stroke.In randomized, double-blind, sham-controlled prospective study, 77 stroke were recruited randomly assigned tDCS group (n = 39) or 38). received anodal (2 mA, 20 min) sham for 4 weeks....
Abstract Background An index of dynamic lactate change that incorporates both the magnitude and time interval such change, termed “normalized load,” may reflect hypoxic burden septic shock. We aimed to evaluate association between normalized load 28-day mortality in adult shock patients. Methods Patients with were identified from Medical Information Mart for Intensive Care (MIMIC)-III database. Lactate was defined as sum area under curve (AUC) serial levels using trapezoidal rule, divided by...
Background Vigorous spontaneous effort can potentially worsen lung injury. This study hypothesized that the prone position would diminish a maldistribution of stress and inflation after diaphragmatic contraction reduce effort, resulting in less Methods A severe acute respiratory distress syndrome model was established by depleting surfactant injurious mechanical ventilation 6 male pigs (“mechanism” protocol) 12 rabbits (“lung injury” protocol). In mechanism protocol, regional inspiratory...
Objective To investigate the correlation analysis of larger side bone cement volume/vertebral body volume ratio (LSBCV/VBV%) with adjacent vertebral compression fracture (AVCF) in percutaneous vertebroplasty (PVP) for osteoporotic (OVCF). Methods A retrospective 245 OVCF patients who underwent PVP treatment from February 2017 to 2021, including 85 males and 160 females. The age ranged 60 92 years, a mean (70.72 ± 7.03) years. According whether AVCF occurred after surgery, they were divided...
Respiratory system elastance (ERS) is an important determinant of the responsiveness intracranial pressure (ICP) to positive end-expiratory (PEEP). However, lung (EL) and chest wall (ECW) were not differentiated in previous studies. We tested hypothesis that patients with high ECW or a ECW/ERS ratio have greater ICP PEEP. An esophageal balloon catheter was placed measure pressure. PEEP increased from 5 15 cmH2O. Airway measured EL, ERS calculated at two levels. Patients classified into...
Limiting driving pressure and mechanical power is associated with reduced mortality risk in both patients without acute respiratory distress syndrome. However, it still poorly understood how the intensity of ventilation its corresponding duration impact mortality.Critically ill who received were identified from Medical Information Mart for Intensive Care (MIMIC)-IV database. A visualization method was developed by calculating odds ratio survival all combinations to assess relationship...
Abstract Background Inflammatory response is activated during cardiopulmonary bypass (CPB), which may lead to acute respiratory distress syndrome (ARDS) and procalcitonin (PCT) increases this inflammatory response. The objective of the study was validate whether patients with higher serum PCT concentrations have a incidence ARDS. Methods prospective, single-center, observational cohort study. All who received cardiac surgery CPB were screened for eligibility. Patients assigned PCT-elevated...
Abstract Background The present study aimed to evaluate the association between normalized lactate load, an index that incorporates magnitude of change and time interval such evolution lactate, 28-day mortality in sepsis non-sepsis patients. We also compared accuracy load predicting these two populations. Methods Data were extracted from Medical Information Mart for Intensive Care (MIMIC)-IV database. defined as sum area under concentration curve; we divided by time. performance maximum mean...
Background It is unclear whether the magnitude and duration of elevated central venous pressure (ECVP) greater than ten mmHg has same impact on mortality in sepsis patients. Methods Critically ill patients with were identified from Medical Information Mart for Intensive Care (MIMIC)-IV database. The ECVP calculated. Normalized load was defined as (the sum value times its duration) divided by total ECVP. primary endpoint 28-day mortality. Kaplan-Meier survival analysis used to compare between...