A5100426910- Meningioma and schwannoma management
- Ophthalmology and Eye Disorders
- Pituitary Gland Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Spinal Cord Injury Research
- Cerebral Venous Sinus Thrombosis
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Neuroimaging Techniques and Applications
- Voice and Speech Disorders
- Peptidase Inhibition and Analysis
- Phonetics and Phonology Research
- Gastrointestinal disorders and treatments
- Growth Hormone and Insulin-like Growth Factors
- Multiple Sclerosis Research Studies
- Glaucoma and retinal disorders
- Coccidia and coccidiosis research
- Trigeminal Neuralgia and Treatments
- Alcohol Consumption and Health Effects
- Cancer Mechanisms and Therapy
- Mechanisms of cancer metastasis
- Facial Nerve Paralysis Treatment and Research
- Parasitic infections in humans and animals
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2024
Chongqing Medical University
2022-2024
Southwest Hospital
2021-2024
Army Medical University
2021-2024
Changsha University
2023-2024
Anhui Medical University
2015-2023
Guangxi Center for Disease Prevention and Control
2023
Harvard University
2021
Anhui University of Traditional Chinese Medicine
2019
Second Affiliated Hospital of Xi'an Jiaotong University
2019
As the first inflammatory cell recruited to site of spinal cord injury (SCI), neutrophils were reported be detrimental SCI. However, precise mechanisms as how exacerbate SCI remain largely obscure. In present study, we demonstrated that infiltrated produce neutrophil extracellular traps (NETs), which subsequently promote neuroinflammation and blood-spinal barrier disruption aggravate edema neuronal apoptosis following in rats. Both inhibition NETs formation by peptidylarginine deiminase 4...
Rationale: Hydrocephalus is a substantial complication after intracerebral hemorrhage (ICH) or intraventricular (IVH) that leads to impaired cerebrospinal fluid (CSF) circulation.Recently, brain meningeal lymphatic vessels (mLVs) were shown serve as critical drainage pathways for CSF.Our previous studies indicated the degradation of neutrophil extracellular traps (NETs) ICH/IVH alleviates hydrocephalus.However, mechanisms by which NET exerts beneficial effects in hydrocephalus remain...
Background Japanese encephalitis virus (JEV; Flaviridae : Flavivirus ) causes (JE), which is the most important arboviral disease in Asia and western Pacific. Among five JEV genotypes (GI–V), GI has dominated traditional epidemic regions past 20 years. We investigated transmission dynamics of through genetic analyses. Methods generated 18 near full length sequences by using multiple sequencing approaches from mosquitoes collected natural settings or viral isolates obtained cell culture....
Sorafenib (SOR) is a multi-kinase inhibitor that was approved as the first-line systematic treatment agent of hepatocellular carcinoma (HCC). However, anti-cancerous effect SOR dramatically impaired by drug resistance, insufficient accumulation at tumor tissues, and limited inner penetration. To combat above issues, PLA-based nanoparticles were first fabricated co-loaded with plantamajoside (PMS), natural herbal medicines possess excellent on many types resistant cancers. Then, polypeptide...
Abstract Objective No relapse risk prediction tool is currently available to guide treatment selection for multiple sclerosis (MS). Leveraging electronic health record (EHR) data readily at the point of care, we developed a clinical predicting MS risk. Methods Using from clinic‐based research registry and linked EHR system between 2006 2016, models events in training set ( n = 1435) tested model performance an independent validation patients 186). This iterative process identified prior...
Abstract Hydrocephalus is a severe complication that can result from intracerebral hemorrhage, especially if this hemorrhage extends into the ventricles. Our previous study indicated NLRP3 inflammasome mediates cerebrospinal fluid hypersecretion in choroid plexus epithelium. However, pathogenesis of posthemorrhagic hydrocephalus remains unclear, and therapeutic strategies for prevention treatment are lacking. In study, an Nlrp3 −/− rat model with ventricular extension primary epithelial cell...
The medial wall of the cavernous sinus is believed to play a significant role in determining direction growth pituitary adenomas and planning surgery. However, it remains unclear whether there dural between gland sinus.To identify trace membranelike structures around their relationships with surrounding structures.Sixteen cadavers (7 females 9 males; age range, 54-89 years; mean age, 77 years) were used this study prepared as 16 sets transverse (5 sets), coronal (2 sagittal (9 sets)...
Three-dimensional anatomical appreciation of the matrix cavernous sinus is one crucial necessities for a better understanding tissue patterning and various disorders in sinus. The purpose this study was to reveal configuration fibrous adipose components their relationship with cranial nerves vessels meningeal wall.Nineteen cadavers (8 females 11 males; age range, 54-89 years; mean age, 75 years) were prepared as transverse (6 sets), coronal (3 sets) sagittal (10 plastinated sections that...
Purpose: This study aimed to clarify the formation and fixation of annulus Zinn (AZ) its relationship with extraocular muscles by using ultrathin plastination three-dimensional models. Methods: Eighteen cadaveric heads (36 sides orbital apex) were plastinated coronal (16 sides), sagittal (13 horizontal (5 sides) sections be investigated at both macroscopic microscopic levels. One head was used for endoscopic dissection identify anatomic landmarks. Results: There two fibrous triangles adhered...
Background It is well known that the clivus composed of abundant cancellous bone and often invaded by pituitary adenoma (PA), but range these corridors unknown. In addition, we found PA with invasion sometimes accompanied petrous apex invasion, so speculated tumor originated from corridor. The aim this study was to test hypothesis investigating bony anatomy associated clival its clinical significance. Methods Twenty-two cadaveric heads were used in anatomical research architecture apex,...
Diabetes-related eye disease is due in part to oxidative stress. Gamma-glutamyl transpeptidase (GGT) a γ-glutamyl cycle enzyme that protects against stress via glutathione recapture. This study investigates corneal and Schirmer tears GGT activity diabetic non-diabetic adults aged 50 83 years old.GGT was determined by colorimetric assay on corneas from 14 (without keratopathy) 20 donors type 1 test strips (no anesthesia) of subjects.Type (T1) cornea 40% lower than Type 2 (T2) (P = 0.04), but...
Sequence variability in two mitochondrial DNA (mtDNA) regions, namely NADH dehydrogenase subunit 5 (nad5) and small of ribosomal RNA (rrnS) Spirometra erinaceieuropaei from dogs Hunan province China was examined. A portion the nad5 (pnad5) rrnS (prrnS) genes were amplified separately individual S. by polymerase chain reaction (PCR). Representative amplicons subjected to sequencing order estimate sequence variability. The sequences pnad5 prrnS 531 328 bp size, respectively. intra-specific...
In the past studies, resistance of magnetically controlled capsules running through small intestine has been modeled assuming that was a circular tube with constant diameter. Peristalsis is an important character human gastrointestinal system, and it would result in some changes diameter intestine, meaning existing models no longer be applicable. this paper, based on assumption intestinal peristalsis actually sinusoidal wave, model capsule peristaltic established, then validated...
To evaluate the utility of apparent diffusion coefficient (ADC) values extraocular muscles (EOMs) in differentiating activity thyroid eye disease (TED). Forty-two TED patients who underwent tensor imaging(DTI) were retrospectively enrolled this study, including 29 analysis group and 13 validation group. The mean, maximum minimum ADC value each EOM regarded as ADCmean, ADCmax ADCmin. difference between ADCmin was △ADC. correlations ADCmean or △ADC clinical score (CAS) assessed. In group,...