Abstract Background Owing to metabolic disequilibrium and immune suppression, intracerebral hemorrhage (ICH) patients are prone infections; according a recent global analysis of stroke cases, approximately 10 million new-onset ICH had experienced concurrent infection. However, the intrinsic mechanisms underlying effects infection related peripheral inflammation after remain unclear. Methods Lipopolysaccharide (LPS) was intraperitoneally injected into model mice induce inflammation....

Abstract Background Hydrocephalus is a severe complication of intracerebral hemorrhage with ventricular extension (ICH-IVH) and causes cerebrospinal fluid (CSF) accumulation. The choroid plexus epithelium plays an important role in CSF secretion constitutes the blood–CSF barrier within brain–immune system interface. Although NLRP3 inflammasome, as key component innate immune system, promotes neuroinflammation, its pathogenesis hydrocephalus after has not been investigated. Therefore, this...

Ground-level ozone (O3) has been an emerging air pollution in China and interacts with fine particulate matters (PM2.5). We synthesized observations of O3 its precursors two summer months 2020 at 10 sites the Zhejiang province, East simulated situ photochemistry. northeastern province was more serious than that southwest. The site-average daytime increment correlated well (R2 = 0.73) total reactivity volatile organic compounds (VOCs) carbon monoxide toward hydroxyl radical (OH) urban areas....

For posthemorrhagic hydrocephalus (PHH) patients, whether occur subependymal edema indicates poor outcomes, partially manifested as cognitive impairment. In the brain, NLRP3 inflammasome mainly derived from microglia/macrophages is involved in proinflammatory and neurodeficits after hemorrhage, autophagy vital for neuronal homeostasis functions. Accumulating evidence suggest that played an essential role intracerebral hemorrhage (ICH). We aimed to dissect mechanisms underlying formation...

Abstract Hydrocephalus is a severe complication that can result from intracerebral hemorrhage, especially if this hemorrhage extends into the ventricles. Our previous study indicated NLRP3 inflammasome mediates cerebrospinal fluid hypersecretion in choroid plexus epithelium. However, pathogenesis of posthemorrhagic hydrocephalus remains unclear, and therapeutic strategies for prevention treatment are lacking. In study, an Nlrp3 −/− rat model with ventricular extension primary epithelial cell...

A hybrid method based on the structural equation model (SEM) and a fuzzy cognitive map (FCM) was developed to study influences of construction safety risks (CSR) metro tunnels constructed by mining project risk (PR). An SEM used identify verify correlations between CSR PR. FCM adopting verified standardized causality path coefficient in SEM. On this basis, predictive reasoning diagnostic were performed framework an simulate The feasibility validated tunnel Wuhan City, China. results show...

Faced with the challenges of global climate change, zero-carbon buildings (ZCB) serve as a crucial means to achieve carbon peak and neutrality goals, particularly in development tropical island regions. This study aims establish ZCB technology system suitable for unique climatic conditions islands. By employing methods such energy flow boundaries, parametric design, data-driven optimization algorithms, research systematically analyzes integrated mechanisms solutions utilization,...

With the acceleration of urbanization, construction urban subway tunnel networks is advancing towards deeper, denser, and larger subterranean forms. Currently, there a lack systematic identification dynamic reasoning analysis factors throughout entire process using mining method. To reduce probability accidents improve safety risk management in whole method, we propose evaluation method based on Fuzzy Set Theory (FST) Bayesian Network (BN). Firstly, main stages Work Breakdown Structure,...

In response to the common issues of lacking a comprehensive quantitative assessment system and insufficient dynamic understanding emergency capability in prefabricated construction safety, this study proposes research methodology based on decision-making trial evaluation laboratory (DEMATEL) fuzzy cognitive maps (FCM) promote capacity. Firstly, indicator comprising 4 core categories organizational management, personnel quality, technical measures, resources, along with 16 main categories, is...

The diagnosis and treatment of glioma depends greatly on the rapid extraction molecular pathological features. In this study, human brain tumor tissues different grades were analyzed using terahertz (THz) attenuated total reflectance (ATR) time-domain spectroscopy. Substantial differences in THz parameters observed between paracarcinoma tissue grade I-IV gliomas, Furthermore, difference absorption coefficient increases with increase frequency. It was also demonstrated that isocitrate...

In the context of global climate change, particularly in tropical island regions, construction sector, a notable contributor to CO2 emissions, necessitates concentrated effort towards enhancing energy efficiency and reducing emissions. This study delves into evolution inherent challenges associated with development zero-carbon buildings such environments. It commences an examination key agreements China's significant progress its dual carbon strategy, specific focus on emission reduction...

This study aims to theoretically explore the technological systems of tropical island zero-carbon building (TIZCB) scientifically understand characteristics these buildings in terms energy utilization, conservation, production, and intelligent system mechanisms. The purpose is address inefficiencies resource wastage caused by traditional segmented approach consumption management. Thus, it seeks achieve a comprehensive understanding application (ZCB) technology system. article focuses on...

Abstract Subarachnoid hemorrhage (SAH) is associated with high mortality and disability rates, secondary white matter injury an important cause of poor prognosis. However, whether brain capillary pericytes can directly affect the differentiation maturation oligodendrocyte precursor cells (OPCs) subsequently repair has still been revealed. This study was designed to investigate effect tissue inhibitor metalloproteinase-3 (TIMP-3) for OPC maturation. PDGFRβ ret/ret wild-type C57B6J male mice...

Most subarachnoid hemorrhage (SAH) patients have no obvious hematoma lesions but exhibit blood-brain barrier dysfunction and vasogenic brain edema. However, there is a few days between blood‒brain The present study sought to investigate whether this phenomenon caused by endothelial injury induced the acute astrocytic barrier, also known as glial limitans. Bioinformatics analyses of human cells astrocytes under hypoxia were performed based on GEO database. Wild-type, EGLN3 PKM2 conditional...

Hepatocellular carcinoma (HCC) is a malignant tumor leading cancer-associated high mortality worldwide. Unfortunately, the most commonly used drug therapeutics not only lack of target ability and efficiency, but also exhibit severe systemic toxicity to normal tissues. Thus, effective targeted nanodrug HCC therapy emerging as more important issue. Here, we design develop novel nanomicelles, namely Mannose-polyethylene glycol 600-Nitroimidazole (Man-NIT). This micelle compound with purity...

Transport infrastructure connectivity is a spatial basis for economic development and the spillover feedback effects of transport investment (TII) have become an impetus growth (EG). However, existing research does not consider TII on gross EG multiple structures. To explore relationships functional routes between EG, Durbin model (SDM) was used to empirically analyze effect from geographical perspectives based panel data 2007 2019 35 members partners Organization Economic Cooperation...

OBJECTIVE Tissue plasminogen activator (tPA) fibrinolysis did not improve functional outcomes of patients with intraventricular hemorrhage (IVH), largely because the unsatisfactory clot clearance. The presence neutrophil extracellular traps (NETs) within has been confirmed to impair tPA fibrinolysis, but mechanism unclear. authors hypothesized that cell-free DNA (cfDNA), main framework NETs, might be important reason for resistance, and they validated hypothesis, hoping provide a new target...

To investigate the differences in epidemiological and clinical characteristics of patients with intracerebral hemorrhage (ICH) treated at our institution over last few decades. Two chronological cohorts ten-year-interval were established data retrospectively collected from ICH, analyzed using SPSS 13.0. The time windows for two January 1, 2010 to December 31, 2014 (2010–2014 cohort) 2000 2004 (2000–2004 cohort). 1598 ICH enrolled: 360 2000–2004 cohort 1238 2010–2014 cohort. often occurred...

A novel fluorescent nanoprobe was prepared to measure H 2 S in plasma and tissue samples from ASD patients model mice.