A5100707575- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- Diet and metabolism studies
- Multiple Sclerosis Research Studies
- Cancer-related molecular mechanisms research
- Ethics in Clinical Research
- Dietary Effects on Health
- Systemic Lupus Erythematosus Research
- Ferroptosis and cancer prognosis
- Pharmaceutical Practices and Patient Outcomes
- Stress Responses and Cortisol
- Pressure Ulcer Prevention and Management
- Acne and Rosacea Treatments and Effects
- Diagnosis and Treatment of Venous Diseases
- Saffron Plant Research Studies
- Breast Implant and Reconstruction
- Drug-Induced Adverse Reactions
- Genetic Associations and Epidemiology
- Cellular Mechanics and Interactions
- Chromatography in Natural Products
- Lipid metabolism and disorders
- Pharmacological Effects and Toxicity Studies
Zhejiang Chinese Medical University
2017-2025
Sun Yat-sen University
2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Shenzhen Nanshan Center for Chronic Disease Control
2024
Henan Cancer Hospital
2023
Zhengzhou University
2023
Boston Children's Hospital
2014-2021
Beijing HuiLongGuan Hospital
2015-2021
Southwest Hospital
2020
Army Medical University
2020
Current evidence indicates a rising global prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD), which is closely associated to conditions such as obesity, dyslipidemia, insulin resistance, and metabolic syndrome. The relationship between the gut microbiome metabolites in NAFLD gaining attention understanding pathogenesis progression dysregulated lipid metabolism inflammation. Xie Zhuo Tiao Zhi (XZTZ) decoction has been employed clinical practice for alleviating hyperlipidemia symptoms...
Abstract Objectives To improve the accuracy of mining structured and unstructured components electronic medical record (EMR) by adding temporal features to automatically identify patients with rheumatoid arthritis (RA) methotrexate-induced liver transaminase abnormalities. Materials methods Codified information a string-matching algorithm were applied RA cohort 5903 from Partners HealthCare select 1130 potential toxicity. Supervised machine learning was as our key method. For features,...
Pharmacologically-induced liver injury from N-acetyl-p-aminophenol (APAP) overdose has become a leading cause of acute failure. Extensive research elucidated the relationship between intestinal microbiota and pathophysiology diseases. The growing body evidence supporting beneficial effects probiotics, coupled with their established safety profile, led to widespread adoption in clinical practice. Among these, Bifidobacterium bifidum garnered substantial attention due its potential...
This study aimed to explore the efficacy and mechanisms of raspberry (Rubus idaeus L. fruit) aqueous extract (RE) in alleviating high-fat diet (HFD)-induced metabolic-associated fatty liver disease (MAFLD). The MAFLD mouse model was established examine effects RE through transcriptome metabolomics analysis. In this study, supplementation significantly alleviated HFD-induced injury, hepatosteatosis, inflammation, insulin resistance. Liver analysis demonstrated that favorably regulated...
Abstract Objective No relapse risk prediction tool is currently available to guide treatment selection for multiple sclerosis (MS). Leveraging electronic health record (EHR) data readily at the point of care, we developed a clinical predicting MS risk. Methods Using from clinic‐based research registry and linked EHR system between 2006 2016, models events in training set ( n = 1435) tested model performance an independent validation patients 186). This iterative process identified prior...
Dietary oil composition determines the pathological processes of alcoholic fatty liver disease (AFLD).
Non-alcoholic fatty liver disease (NAFLD) is a challenging to interfere with and represents potential long-term risk factor for hepatic fibrosis cancer. The Xiezhuo Tiaozhi (XZTZ) formula, water extract from crude herbs, has been widely used as an anti-NAFLD agent through clinical observation. However, the underlying pharmacological mechanisms of XZTZ formula its impact on pathways against NAFLD have not elucidated. Our study aims investigate effects regulatory treat NAFLD. possible active...
To analyze the sociodemographic and clinical factors related to anxiety in patients with major depressive disorder (MDD).This study involved a secondary analysis of data obtained from Diagnostic Assessment Service for People Bipolar Disorders China (DASP), which was initiated by Chinese Society Psychiatry (CSP) conducted September 1, 2010 February 28, 2011. Based on presence or absence anxiety-related characteristics, 1,178 MDD were classified as suffering anxious depression (n=915)...
Nonalcoholic fatty liver disease (NAFLD) causes significant global mortality and healthcare costs with no recommended pharmacological intervention for clinical management. Nuciferine (Nuc) is an alkaloid aromatic rings, abundantly found in
Abstract Background and aims Excessive alcohol consumption predisposes drinkers to develop alcoholic cardiomyopathy. Although cardiomyocyte loss is the hallmark of cardiomyopathy, underlying mechanism remains elusive. This study examined potential alcohol‐induced death in a mouse model Methods We established cardiomyopathy using C57BL/6J mice confirmed it via echocardiography histological examination. The cardiac ceramide content profile were analyzed with triple‐quadrupole mass...
A landmark study from the Institute of Medicine reported that assessment cognitive difficulties in children with epilepsy is timely and imperative. Anticonvulsant-induced impairment could influence quality life more than seizure itself patients. Although monoaminergic system involved regulation process, its role anticonvulsant-induced remains unclear. <b>Methods:</b> To explore vivo monoamine receptor binding activity patients impairment, each patient underwent PET imaging both agent...
Telomere shortening is an accepted indicator of aging. Many studies have investigated association between leukocyte telomere length (LTL) and psychiatric disorders. Mental or psychological factors could be important cause irritable bowel syndrome (IBS). However, there are currently few research evaluating correlations LTL IBS.We examined associations IBS using quantitative polymerase chain reaction in independent cohorts, including 205 patients with 189 healthy controls. Furthermore, we...
We present the case of a 41‐year‐old man who developed photodistributed eruption 1 month after being started on 2‐mercaptoethane sulfonate sodium (mesna) for treatment cyclophosphamide‐induced haemorrhagic cystitis. The patient had background history Wegener granulomatosis, and been taking cyclophosphamide at stable dose 150 mg daily previous 3 years. Complete resolution rash occurred within 8 weeks cessation mesna. This is first reported case, to our knowledge, mesna‐induced dermatosis....
Dynamic and precise estimation of blood loss (EBL) is quite important for perioperative management. To date, the Triton System, based on feature extraction technology (FET), has been applied to estimate intra-operative haemoglobin (Hb) but unable directly assess amount loss. We aimed develop a method dynamic EBL Hb (EHL) artificial intelligence (AI).We collected surgical patients' non-recycled generate blood-soaked sponges at set gradient volume. After image acquisition preprocessing, FET...
Abstract N-acetylcysteine (NAC) possesses a strong capability to ameliorate high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in mice, but the underlying mechanism is still unknown. Our study aimed clarify involvement of long non-coding RNA (lncRNA) beneficial effects NAC on HFD-induced NAFLD. C57BL/6J mice were fed normal-fat (10 % fat), HFD (45 fat) or plus (2 g/l). After 14-week intervention, rescued deleterious alterations induced by HFD, including changes body and...
ABSTRACT OBJECTIVE To analyze the occurrence of symptoms and quality life (QoL) among patients with chronic wounds impact on QoL. METHODS Researchers evaluated 200 using a general information questionnaire, modified version Memorial Symptom Assessment Scale, Chinese Cardiff Wound Impact Questionnaire. They performed correlation linear regression analyses to explore RESULTS Mean scores were all moderately severe ranged as follows: 0 7.06 ± 3.85 for mean total symptom, 2.69 1.33 frequency,...