A5101609514- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Immune cells in cancer
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- Neonatal Respiratory Health Research
- Liver Disease Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Gestational Diabetes Research and Management
- Parental Involvement in Education
- Ferroptosis and cancer prognosis
- T-cell and B-cell Immunology
- Bariatric Surgery and Outcomes
- Meta-analysis and systematic reviews
- Extracellular vesicles in disease
- Cancer Genomics and Diagnostics
- Family and Disability Support Research
- Histone Deacetylase Inhibitors Research
- Chromatin Remodeling and Cancer
Lanzhou University
2017-2025
Lanzhou University Second Hospital
2022-2025
Hebei Medical University
2010-2025
Third Hospital of Hebei Medical University
2012-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2015-2024
Johns Hopkins University
2024
China Agricultural University
2023-2024
Jiaxing University
2024
Shanghai University of Medicine and Health Sciences
2018-2024
Anhui University of Science and Technology
2021-2024
Abstract Chromatin modification is pivotal to the epithelial–mesenchymal transition (EMT), which confers potent metastatic potential cancer cells. Here, we report a role for chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), prevalent China. LSH expression was increased NPC, where it controlled by Epstein–Barr virus-encoded protein LMP1. In NPC cells vitro and vivo, promoted progression part regulating of fumarate hydratase (FH), core component...
Ferroptosis is a form of iron-dependent programmed cell death that differs from apoptosis with regards to both mechanism and morphology. Therefore, ferroptotic-based cancer therapy has shown significant potential overcome the weaknesses conventional therapeutics mediated by pathways. Effective ferroptosis can be induced intracellular Fenton reaction dependent on adequate supply iron ions H
Abstract Traumatic brain injury (TBI) accelerates fracture healing, but the underlying mechanism remains largely unknown. Accumulating evidence indicates that central nervous system (CNS) plays a pivotal role in regulating immune and skeletal homeostasis. However, impact of CNS on hematopoiesis commitment was overlooked. Here, we found dramatically elevated sympathetic tone accompanied with TBI-accelerated healing; chemical sympathectomy blocks TBI-induced healing. hypersensitivity...
Abstract Background Lewy body dementia (LBD) ranks second among prevalent neurodegenerative dementias. Previous studies have revealed associations of serum lipid measures with several diseases. Nevertheless, the potential connection between lipids and LBD remains undetermined. In this study, Mendelian randomization (MR) analyses were carried out to assess causal relationships risk developing LBD. Methods Genome-wide association study (GWAS) data for in European descent individuals acquired...
Osteoarthritis (OA) is an age-related chronic inflammatory disease, predominantly characterized by chondrocyte senescence and extracellular matrix (ECM) degradation. Although mesenchymal stem cells (MSCs) derived vesicles (EVs) are promising for promoting cartilage regeneration, their clinical application limited inconsistent therapeutic effects insufficient targeting capabilities. Mechanical loading shows potential to optimize MSC-EVs OA treatment, while the underlying mechanism not clear....
Abstract Most cancer patients receive radiotherapy in the course of their disease and occurrence radioresistance is associated with poor prognosis. The molecular pathways that drive enhanced tumorigenic potential during development are poorly understood. Here, we demonstrate aryl hydrocarbon receptor (AhR) plays a vital role maintenance stem-like properties. AhR promotes phenotype drives metastasis by directly targeting promoters ‘stemness’ genes, such as ATP-binding cassette sub-family G...
The correlation between low serum PG level and H. pylori infection with the development of gastric cancer has caused considerable concerns all over world. Some authors exclaimed that developed only in patients infected pylori, whereas other had different findings. In this study, 1,501 adult local residents determined levels anti IgG status were followed for 14 years a rural community high risk Hebei Province, China. results showed accumulated incidence subjects abnormal those significantly...
Sphingosine kinase1 (SphK1) is an oncogenic enzyme that regulates tumor cell apoptosis, proliferation and survival. SphK1 has been reported to promote the development of non‑small lung cancer (NSCLC), although underlying mechanism remains be determined. The aim present study was examine expression function in NSCLC explore molecular mechanism. results demonstrated upregulated tissues lines. Overexpression increased migration cells. Additionally, overexpression induced antiapoptotic...
Epithelial ovarian cancer (EOC) is a gynecological malignancy with high morbidity. Treating EOC remains challenge, as the pathogenesis of this disease unclear and chemoresistance common occurrence. A number previous studies have revealed that obesity closely associated leptin, link between obesity, has become focus research in recent years. In present study, survival database analysis demonstrated leptin expression was poor prognoses patients treated platinum paclitaxel/docetaxel. cell...
Triple-negative breast cancer (TNBC) is an aggressive subtype of cancer, which very difficult to treat and commonly develops resistance chemotherapy. The following study investigated whether the inhibition Flap Endonuclease 1 (FEN1) expression, key enzyme in base excision repair (BER) pathway, could improve anti-tumor effect arsenic trioxide (ATO), a reactive oxygen species (ROS) inducer. Our data showed that ATO increase expression FEN1, knockdown FEN1 significantly enhance sensitivity TNBC...
Integrin subunit alpha 9 (ITGA9) mediates cell-cell and cell-matrix adhesion, cell migration, invasion through binding different kinds of extracellular matrix (ECM) components. However, its potential role underlying molecular mechanisms remain unclear in hepatocellular carcinoma (HCC). Here, we found that ITGA9 expression was obviously decreased patients with HCC, which negatively correlated HCC growth metastasis. overexpression significantly inhibited proliferation migration vitro as well...
Aerobic glycolysis, also known as the Warburg effect, is emerged a hallmark of most cancer cells. Increased aerobic glycolysis closely associated with tumor aggressiveness and predicts poor prognosis. Pancreatic ductal adenocarcinoma (PDAC) characterized by prominent genomic aberrations increased glycolytic phenotype. However, detailed molecular events implicated in PDAC are not well understood. In this study, we performed comprehensive characterization using multidimensional ''omic'' data...
S100 calcium-binding protein A8 (S100A8) and S100A9 are small molecular weight regulatory proteins that have been involved in multiple chronic inflammatory diseases. However, the role of S100A8 keratinocytes wounded skin how they regulated during this process still unclear. Here, we found were both upregulated burn-wounded skins vivo thermal-stimulated epidermal vitro, accompanied by increased levels epithelial-mesenchymal transition (EMT). Then, demonstrated upregulation alone or together...
Abstract Background A series of evidence revealed that body mass index was an important confounding factor in the research uric acid and ischemic heart disease/hypertension. The objective this study to investigate whether obesity status can modify association between serum severity liver damage NAFLD, possible interactive effect hyperuricemia obesity. Methods We conducted a cross-sectional total 557 ultrasound diagnosed-NAFLD. hepatic steatosis fibrosis were quantitatively evaluated by...
Abstract Lung adenocarcinoma (LUAD) is a common diagnosed disease with high‐mortality rate, and its prognostic implications are under discovered. DNA methylation aberrations not only an important event for dysregulation of gene expression during tumorigenesis but also revolution in epigenetics by identifying key biomarkers multiple cancers. In this study, we analyzed status 485 578 CpG sites RNA‐seq transcriptomes 20 532 genes 1095 LUAD samples TCGA database. The association between the...