A5102788655- Marine Sponges and Natural Products
- Cardiac Valve Diseases and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Hypoxia, and Metabolism
- MRI in cancer diagnosis
- Microbial Natural Products and Biosynthesis
- Aortic Disease and Treatment Approaches
- Colorectal Cancer Treatments and Studies
- Mental Health Research Topics
- Advanced Breast Cancer Therapies
- Cancer-related molecular mechanisms research
- IgG4-Related and Inflammatory Diseases
- Tryptophan and brain disorders
- Soft tissue tumor case studies
- Histiocytic Disorders and Treatments
- RNA modifications and cancer
- Extracellular vesicles in disease
- Synthesis and Biological Evaluation
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Folate and B Vitamins Research
- Molecular Biology Techniques and Applications
- Circular RNAs in diseases
- Sirtuins and Resveratrol in Medicine
- Animal Virus Infections Studies
Southern Medical University
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
First Affiliated Hospital of Soochow University
2023-2024
Chinese Academy of Sciences
2023-2024
Soochow University
2023-2024
South China Sea Institute Of Oceanology
2023-2024
Hubei University of Medicine
2023-2024
Taihe Hospital
2023-2024
Jiangsu University
2024
Institute of Oceanology
2023-2024
Abstract Background Aortic valve stenosis (AVS) is the most prevalent cardiac lesion in developed countries, and pathogenesis closely related to aging. DNA methylation-based epigenetic clock now recognized as highly accurate predictor of aging process associated health outcomes. This study aimed explore causal relationship between AVS by conducting a bidirectional Mendelian randomization (MR) analysis. Methods Summary genome-wide association statistics clocks (HannumAge, HorvathAge,...
Exosomes, one of small extracellular vesicles, play a vital role in cell to communication and contribute the advancement tumors through their cargo molecules. Exosomal circRNAs have emerged as significant players various types tumors. Thus, this study aimed investigate how exosomal are involved diagnosis progression gastric cancer (GC).
Abstract Background The initiation of fibroblast growth factor 1 (FGF1) expression coincident with the decrease FGF2 is a well-documented event in prostate cancer (PCa) progression. Lactate dehydrogenase A (LDHA) and LDHB are essential metabolic products that promote tumor growth. However, relationship between FGF1/FGF2 LDHA/B-mediated glycolysis PCa progression not reported. Thus, we aimed to explore whether FGF1/2 could regulate LDHA explored involved signaling pathway Methods In vitro...
Abstract Background Lewy body dementia (LBD) ranks second among prevalent neurodegenerative dementias. Previous studies have revealed associations of serum lipid measures with several diseases. Nevertheless, the potential connection between lipids and LBD remains undetermined. In this study, Mendelian randomization (MR) analyses were carried out to assess causal relationships risk developing LBD. Methods Genome-wide association study (GWAS) data for in European descent individuals acquired...
Abstract Background Our previous studies demonstrated that 1-Pyrroline-5-carboxylate (P5C) released by prostate cancer cells inhibits T cell proliferation and function increasing SHP1 expression. We designed this study to further explore the influence of P5C on metabolism, produced an antibody for targeting restore functions cells. Method co-immunoprecipated from analyzed proteins were bound it using liquid chromatography mass spectrometry (LC/MS-MS). The metabolism was also detected...
Background 2’,5’-oligoadenylate synthetase 1 (OAS1), has been reported as a tumor driver gene in breast carcinoma and pancreatic carcinoma. However, the role of OAS1 most tumors not reported. Methods The original data 35 types were down load from TCGA (The Cancer Genome Atlas) database Human Protein Atlas (HPA) database. TIMER2, Kmplot, UALCAN, TISIDB tools used to investigate expression function OAS1, prognosis, diagnostic value, immune characteristics pan-cancer. LUAD PRAD cell lines,...
The one strain many compounds (OSMAC) strategy is an effective method for activating silent gene clusters by cultivating microorganisms under various conditions. whole genome sequence of the marine-derived
Objectives To explore the utility of gray-scale ultrasound (GSUS) and mammography (MG) for radiomic analysis in distinguishing between breast adenosis invasive ductal carcinoma (IDC). Methods Data from 147 female patients with pathologically confirmed lesions (breast adenosis: 61 patients; IDC: 86 patients) January 2018 December 2022 were retrospectively collected. A training cohort 113 50 63 diagnosed to 2021 a time-independent test 34 11 23 included. Radiomic features extracted MG GSUS...
Background The National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin scale (mRS) scores have important shortcomings. Amide proton transfer‐weighted (APTw) imaging might offer more valuable information in ischemic strokes assessment. Purpose To utilize APTw, apparent diffusion coefficient (ADC), computed tomography perfusion (CTP) for assessment clinical symptom severity 90‐day prognosis patients diagnosed with stroke. Study Type Prospective. Subjects 61 (mean age 63.2 ±...
Aortic valve stenosis (AVS) is currently the most common heart disease. The results of observational studies on incidence AVS in renal dysfunction population are contradictory due to short follow-up period and different diagnostic criteria, etc. This study aimed explore causal relationship between kidney function using Mendelian randomization (MR) analysis.
The calcium-activated chloride channel (CLCA2) performs a vital function in the intricate process of tumorigenesis. Using bioinformatics analysis system, we conducted pan-cancer investigation on CLCA2 to explore its association with tumor prognosis and involvement immunology. In order achieve this objective, examined prognostic significance expression level multiple cancer types using TIMER Sangerbox databases. protein interaction networks revealed proteins linked CLCA2. To investigate...
Marine symbiotic and epiphyte microorganisms are sources of bioactive or structurally novel natural products. Metabolic blockade-based genome mining has been proven to be an effective strategy accelerate the discovery products from both terrestrial marine microorganisms. Here, metabolic was applied other metabolites in a sea anemone-associated
Aim: This study aimed to establish a simple whole-genome sequencing method for respiratory virus type A (RSVA) used in genomic epidemiological studies. Methods: Multiple primers were designed amplify overlapping amplicons specific RSVA. The sequenced using Illumina and Nanopore platforms the performances of two also compared. Results: shows that developed could recover almost full genomes RSVA when Ct values less than 33 clinical samples. Conclusion: In this study, was based on multiplex PCR.
Abstract Background: Our previous studies demonstrated that 1-Pyrroline-5-carboxylate (P5C) released by prostate cancer cells inhibit T cell proliferation and function. We designed this study to further explore the influence of P5C on metabolism, produce an antibody for targeting restore functions cells. Method: obtained SHP1 from through co-immunoprecipitation analyzed proteins were co-immunoprecipitated with using liquid chromatography mass spectrometry (LC/MS-MS). The metabolism also...
To probe the action of shikonin on cardiomyocyte damage triggered by high glucose and its possible mechanism. High was used to induce rat H9C2 establish a cell injury model, different doses were treat cells. Flow cytometry tested apoptosis. The enzyme-labeled method water-soluble tetrazolium salt detect superoxide dismutase malondialdehyde content, respectively. Quantitative reverse transcription polymerase chain reaction assayed circ_0000491 levels. After treatment, apoptosis rate cells,...