A5020991642- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Nuts composition and effects
- MicroRNA in disease regulation
- RNA Research and Splicing
- Mycobacterium research and diagnosis
- Antimicrobial Peptides and Activities
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- interferon and immune responses
- Renin-Angiotensin System Studies
- Biochemical Analysis and Sensing Techniques
- FOXO transcription factor regulation
- Second Language Learning and Teaching
- Hormonal Regulation and Hypertension
- EFL/ESL Teaching and Learning
- Neurobiology and Insect Physiology Research
- ATP Synthase and ATPases Research
- Cytokine Signaling Pathways and Interactions
- Second Language Acquisition and Learning
Harbin Medical University
2020-2023
Shanghai Jiao Tong University
2020-2022
Tongren Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
University of International Relations
2022
Mudanjiang Medical University
2019-2021
First Affiliated Hospital of Henan University of Science and Technology
2017
Long noncoding RNAs (lncRNAs) play important roles in the regulation of gene expression by acting as competing endogenous (ceRNAs). However, lncRNA-associated ceRNAs oncogenesis are not fully understood. The present study aims to determine whether a ceRNA network can serve prognostic marker human prostate cancer (PCa). In order identify and key lncRNAs PCa, we constructed differentially expressed (DELs)-differentially miRNAs (DEMis)-differentially mRNAs (DEMs) regulatory based on theory...
Abstract Background As an oncogene, long noncoding RNA metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) can promote tumor metastasis. Hyperexpression of MALAT1 has been observed in many malignant tumors, including hepatocellular carcinoma (HCC). However, the role and mechanism HCC remain unclear. Methods Thirty human paracancerous tissue specimens were collected, hepatoma cell lines Huh7 HepG2 cultured according to standard methods. Snail family zinc finger (Slug) expression...
Background: Long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of multiple tumors. However, roles lncRNAs during colon adenocarcinoma and cancer progression remain unclear. This study aimed identify new that act as molecular markers for prevention diagnosis adenocarcinoma. Methods: RNA sequencing (RNA-Seq) data associated with were retrieved from Cancer Genome Atlas (TCGA). Biological processes Gene Ontology (Go) Kyoto Encyclopedia Genomes (KEGG) searched pathways at...
Cervical cancer is one of the most common malignant tumors in women, and its morbidity mortality are increasing year by worldwide. Therefore, an urgent challenging task to identify potential biomarkers for cervical cancer. This study aims hub genes based on GEO database then validate their prognostic values multiple databases. By analysis, we obtained 83 co-expressed differential from ( GSE63514 , GSE67522 GSE39001 ). GO KEGG enrichment analysis showed that these it mainly involved DNA...
Long non‑coding RNAs (lncRNAs) are markedly involved in cancer progression. Thus, identification of these lncRNAs can aid the treatment cancer. The present study focused on investigating overall biological function, mechanism action and clinical importance lncRNA AC245100.4 prostate (PCa). identified that expression was significantly upregulated PCa tissues cell lines. Knockdown impaired tumor growth an animal model. Biological function analysis indicated overexpression notably promoted...
MiRNAs can regulate gene expression directly or indirectly, and long noncoding RNAs as competing endogenous RNA (ceRNAs) bind to miRNAs competitively affect mRNA expression. The ceRNA network is still unclear in breast cancer. In this study, a was constructed, new treatment prognosis targets biomarkers for cancer were explored.
Despite the increasing awareness of digital games’ potential for language learning, only a handful studies focus on their integration into classrooms. Informed by bridging activities, this mixed methods case study recruited six students to engage in instructed gameplay class and game-related activities after class. Both qualitative quantitative data were collected analyzed so as measure participants’ learning outcome, document engagement, explore perceptions game-based learning. Results...
The forkhead box F2 (Foxf2) gene suppresses epithelial-mesenchymal transition via the modulation of transcription zinc finger E-box-binding homeobox 1 (Zeb1) and epithelial (E)-cadherin, thereby inhibiting tumor metastasis.Additionally, specific binding microRNA (miR)-200c to Foxf2 mRNA impedes metastatic pulmonary cancer.However, role miR-200c in breast cancer is still unknown.Therefore, this study, mimics were transfected into highly cell line MDA-MB-231.Their invasion migration abilities...
The coronavirus papain-like protease (PLpro) of severe acute respiratory syndrome 2 (SARS-CoV-2) is responsible for viral polypeptide cleavage and the deISGylation interferon-stimulated gene 15 (ISG15), which enable it to participate in virus replication host innate immune pathways. Therefore, PLpro considered an attractive antiviral drug target. Here, we show that parthenolide, a germacrane sesquiterpene lactone, has SARS-CoV-2 inhibitory activity. Parthenolide covalently binds Cys-191 or...
Abstract Background: Increasing evidences show that long non-coding RNA (lncRNA) plays the role of competitive endogenous RNAs (ceRNAs) in development and progression cancers. The purpose our study was to identify potential lncRNA biomarkers serve as a therapeutic target prognostic biomarker HCC. Methods: differential expression examined using edgeR package. Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analysis were used predict functions. Survival ROC curve...