A5015228968- Neuroscience and Neural Engineering
- Cardiac electrophysiology and arrhythmias
- Advanced Sensor and Energy Harvesting Materials
- Conducting polymers and applications
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- 3D Printing in Biomedical Research
- Neural dynamics and brain function
- Ion channel regulation and function
- Advanced Memory and Neural Computing
- Photoreceptor and optogenetics research
- Analytical Chemistry and Sensors
- Receptor Mechanisms and Signaling
- Pluripotent Stem Cells Research
- Diamond and Carbon-based Materials Research
- Electrochemical Analysis and Applications
- Cardiac Ischemia and Reperfusion
- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Tactile and Sensory Interactions
- Advanced Materials and Mechanics
- Semiconductor materials and devices
- Molecular Communication and Nanonetworks
- Corrosion Behavior and Inhibition
- stochastic dynamics and bifurcation
Zhejiang University of Technology
2024
Nanjing University of Chinese Medicine
2024
Shanxi Normal University
2024
Shanxi Science and Technology Department
2024
China Tobacco
2023
Hebei University of Technology
2022
The Ohio State University
2013-2021
Frederick National Laboratory for Cancer Research
2014-2021
Xidian University
2021
Bristol-Myers Squibb (United States)
2021
Mini Mighty Muscle Actuators—or artificial muscles—take electrical or chemical energy and convert it into mechanical force. Typically, actuators made from polymers can show large deformations, but cannot generate a lot of Ma et al. (p. 186 ; see the Perspective by Kim Kwon ) describe polymer composite based on modified polypyrrole that expands in response to water absorption. The was able stresses forces, offered high work density approaching those best conducting electrochemical actuators....
Human-induced pluripotent stem cells (hiPSCs) can differentiate into functional cardiomyocytes; however, the electrophysiological properties of hiPSC-derived cardiomyocytes have yet to be fully characterized. We performed detailed characterization highly pure cardiomyocytes. Action potentials (APs) were recorded from spontaneously beating using a perforated patch method and had atrial-, nodal-, ventricular-like properties. Ventricular-like APs more common maximum diastolic close those human...
To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as an in vitro proarrhythmia model, we evaluated concentration dependence and sources variability electrophysiologic responses to 28 drugs linked low, intermediate, high torsades de pointes (TdP) risk categories using two commercial cell lines standardized protocols a blinded multisite study multielectrode array or voltage-sensing optical approaches. Logistical ordinal linear regression models...
Improved in vitro systems for predicting drug-induced toxicity are needed the pharmaceutical and biotechnology industries to decrease late-stage drug attrition. One unmet need is an early screen cardiotoxicity, which accounts about one third of safety-based withdrawn pharmaceuticals. Herein, first published report a high-throughput functional assay employing monolayer beating human induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs) described, detailing model that accurately...
Numerous applications in neuroscience research and neural prosthetics, such as electrocorticogram (ECoG) recording retinal prosthesis, involve electrical interactions with soft excitable tissues using a surface and/or stimulation approach. These require an interface that is capable of setting up high-throughput communications between the circuit tissue can dynamically conform to shape tissue. Being compliant material mechanical impedance close tissues, polydimethylsiloxane (PDMS) offers...
Implantable microelectrode arrays (MEAs) have been a boon for neural stimulation and recording experiments. Commercially available MEAs high impedances, due to their low surface area small tip diameters, which are suitable single unit activity. Lowering the electrode impedance, but preserving diameter, would provide number of advantages, including reduced voltages, artifacts improved signal-to-noise ratio. Impedance reductions can be achieved by electroplating with platinum (Pt) black,...
Human induced pluripotent stem cell–derived cardiomyocytes (hiPS-CMs) are capable of detecting drug-induced clinical arrhythmia, Torsade de Pointes (TdP), and QT prolongation. Efforts herein employ a broad set structurally diverse drugs to optimize the predictive algorithm for applications in discovery toxicology cardiac safety screening. The changes beat rhythm rate confluent monolayer hiPS-CMs by 88 marketed 30 internal compounds were detected with real-time cellular impedance measurement...
A highly stretchable neural interface of concurrent robust electrical and mechanical properties is developed with a conducting polymer film as the sole conductor for both electrodes leads. This offers benefits in demanding format, including low electrode impedance high chargeinjection capacity, due to large electroactive surface area electrode. As service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be...
Recent in vitro cardiac safety studies demonstrate the ability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to detect electrophysiologic effects drugs. However, variability contributed by unique approaches, procedures, cell lines, and reagents across laboratories makes comparisons results difficult, leading uncertainty about role hiPSC-CMs defining proarrhythmic risk drug discovery regulatory submissions. A blinded pilot study was conducted evaluate 8...
Zinc oxide (ZnO)-based photoanodes with sunlight photocatalytic activity are widely used in dye-sensitized solar cells. Presently, most of such electrodes inflexible due to the rigidness ZnO and substrate, thus hindering their application flexible electronics. Here, we report a composite film microrod arrays polypyrrole (PPy) featuring significant flexibility, durability, capability under visible light. In this film, upper section microrods is coated an approximately 400 nm thick PPy shell,...
High-density stretchable electronics are achieved using multilayer interconnects on an elastomeric substrate. Two major challenges associated with electronics—increasing integration density and improving electrical bonding—have been addressed by our innovative via-bonding technology. The resulting multichip-module architecture provides elastic, high-density solution for numerous potential applications.
Background/aims: Monitoring changes in the field potential (FP) of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) following compound administration has been proposed as a novel screening tool to evaluate cardiac ion channel interactions and QT liability. Here we extended use FP pharmacological toxicological properties glycosides. Methods: FPs were recorded using microelectrode arrays (MEAs) spontaneously beating hiPSC-CMs. The vitro effects ouabain digoxin on compared...
High-resolution, high-density gold interconnects are effectively patterned on an elastomeric substrate. A 3 cm cable of ten wires with 10 μm width and 20 pitch is achieved, successfully demonstrating density increases more than one order magnitude from previously established work. Many applications in the fields stretchable electronics conformable neural interfaces will benefit these fabrication developments. Detailed facts importance to specialist readers published as "Supporting...
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are being used as an in vitro model system cardiac biology and drug discovery (e.g., cardiotoxicity testing). Qualification of these cells for use mechanistic investigations will require detailed evaluations cardiomyocyte signaling pathways cellular responses. ErbB the ligand neuregulin play critical roles survival functional integrity myocytes. As such, we sought to characterize expression activity family receptors....