A5078008541- Neuroscience and Neural Engineering
- Infection Control and Ventilation
- COVID-19 and healthcare impacts
- Muscle activation and electromyography studies
- Photoreceptor and optogenetics research
- Pain Management and Treatment
- Botulinum Toxin and Related Neurological Disorders
- EEG and Brain-Computer Interfaces
- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Burn Injury Management and Outcomes
- Dental Research and COVID-19
- Vagus Nerve Stimulation Research
- Urinary Bladder and Prostate Research
- Aerosol Filtration and Electrostatic Precipitation
- 3D Printing in Biomedical Research
- Advanced MRI Techniques and Applications
- Wireless Body Area Networks
- Cardiac pacing and defibrillation studies
- Pain Management and Placebo Effect
- Advanced Sensor and Energy Harvesting Materials
- Advancements in Transdermal Drug Delivery
- Optical Imaging and Spectroscopy Techniques
- Musculoskeletal pain and rehabilitation
- Non-Invasive Vital Sign Monitoring
Washington University in St. Louis
2016-2025
VA St. Louis Health Care System
2025
Georgia Institute of Technology
2007-2011
Emory University
2010
The Wallace H. Coulter Department of Biomedical Engineering
2010
The fast-growing field of bioelectronic medicine aims to develop engineered systems that can relieve clinical conditions by stimulating the peripheral nervous system1-5. This type technology relies largely on electrical stimulation provide neuromodulation organ function or pain. One example is sacral nerve treat overactive bladder, urinary incontinence and interstitial cystitis (also known as bladder pain syndrome)4,6,7. Conventional, continuous protocols, however, cause discomfort pain,...
Wireless, battery-free optoelectronic systems enable localized tissue oximetry in tether-free, awake animal models.
Abstract Bioresorbable electronic materials serve as foundations for implantable devices that provide active diagnostic or therapeutic function over a timeframe matched to biological process, and then disappear within the body avoid secondary surgical extraction. Approaches power supply in these physically transient systems are critically important. This paper describes fully biodegradable, monocrystalline silicon photovoltaic (PV) platform based on microscale cells (microcells) designed...
Abstract Spinal cord stimulation (SCS) for chronic pain management is an invasive therapy involving surgical implantation of electrodes into spinal epidural space. While the clinical value and mechanistic action debated considerably in recent years, preclinical studies employing rodent models can provide invaluable insights regarding balance between efficacy complications as well understanding SCS therapy. However, current compatible devices require tethered power delivery or bulky...
Infections related to neuromodulation devices such as spinal cord stimulators (SCS) and intrathecal pumps (ITPs) present complex challenges due potential complications localized infections, deep sepsis, neurological injury. Prompt diagnosis requires patients providers be educated on wound management sepsis symptoms for immediate medical attention. Antibiotic therapy duration vary based infection severity, with infections often requiring device removal despite recent improvements in salvage...
A method for fabricating polydimethylsiloxane (PDMS) based microelectrode arrays (MEAs) featuring novel conical-well microelectrodes is described. The fabrication technique reliable and efficient, facilitates controllability over both the depth slope of conical wells. Because high-PDMS elasticity (as compared to other MEA substrate materials), this type compliant promising acute chronic implantation in applications that benefit from conformable device contact with biological tissue surfaces...
Rationale and ObjectiveThree-dimensional (3D) printing allows innovative solutions for personal protective equipment, particularly in times of crisis. Our goal was to generate an N95-alternative 3D-printed respirator that passed Occupational Safety Health Administration (OSHA)-certified quantitative fit testing during the COVID-19 pandemic.Materials Methods3D printed prototypes N95 were created based on design commercial respirators. Computed tomography imaging performed anthropomorphic head...
By electrically stimulating the spinal cord, it is possible to activate functional populations of neurons that modulate motor and sensory function. One method for accessing these via their associated axons, which project as functionally-segregated longitudinal columns white- matter funiculi (i.e., tracts). To stimulate tracts without penetrating we have recently developed technology enables close-proximity, multi-electrode contact with cord surface. Our stretchable microelectrode arrays...
The use of facemasks is proven to mitigate the spread coronavirus and other biological agents that cause disease. Various forms facemasks, made using different materials, are being used extensively, it important determine their performance characteristics. size-dependent filtration efficiency breathing resistance household sterilization wrap fabrics, isolation media (American Society for Testing Materials (ASTM)- non-ASTM-rated), were measured in filter-holder- mannequin-in-chamber-based...
The COVID-19 pandemic has precipitated widespread shortages of filtering facepiece respirators (FFRs) and the creation sharing proposed substitutes (novel designs, repurposed materials) with limited testing against regulatory standards. We aimed to categorically test efficacy fit potential N95 respirator using protocols that can be replicated in university laboratories.
Intravenous lidocaine can alleviate painful diabetic peripheral neuropathy (DPN) in some patients. Whether quantitative sensory testing (QST) identify treatment responders has not been prospectively tested.This was a prospective, randomized, double-blind, crossover, placebo-controlled trial comparing intravenous to normal saline (placebo) for DPN. Thirty-four participants with DPN were enrolled and administered (5 mg/kg ideal body weight) or placebo as 40-minute infusion, after battery of...
Novel designs and materials for filtering face-piece respirators (FFRs) have been disseminated in response to shortages during the COVID-19 pandemic. Since filtration efficiency depends on particle diameter air face velocity, relevance of material or prototype fit data test conditions. We investigate whether characterizing a filter holder at range velocities enabled precise prediction performance novel sewn mask design. While larger particles (> 500 nm) are more relevant inhalation exposure...