A5037980959- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Immune responses and vaccinations
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- T-cell and B-cell Immunology
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Drug-Induced Adverse Reactions
- Respiratory viral infections research
- RNA modifications and cancer
- Immune Response and Inflammation
- Cardiac pacing and defibrillation studies
- Influenza Virus Research Studies
- Cutaneous Melanoma Detection and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Ocular Oncology and Treatments
- Autoimmune Neurological Disorders and Treatments
- Melanoma and MAPK Pathways
- Bacterial Infections and Vaccines
- Obsessive-Compulsive Spectrum Disorders
Task Applied Science
2025
South African Tuberculosis Vaccine Initiative
2016-2023
University of Cape Town
2016-2023
Texas Tech University Health Sciences Center
2018
Texas Tech University
2018
One third of the global population is estimated to be latently infected with Mycobacterium tuberculosis We performed a phase I randomized controlled trial isoniazid preventive therapy (IPT) before revaccination bacillus Calmette-Guérin (BCG) in healthy, tuberculin skin test-positive (≥15-mm induration), HIV-negative South African adults. hypothesized that preclearance latent bacilli IPT modulates BCG immunogenicity following revaccination. Frequencies and coexpression IFN-γ, TNF-α, IL-2,...
Abstract Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently needed. We developed a robust simple, PCR-based host-blood transcriptomic signature, RISK6, multiple applications: identifying individuals at risk of incident disease, as screening test subclinical or clinical tuberculosis, treatment. RISK6 utility was validated by blind prediction using quantitative real-time (qRT) PCR in seven independent cohorts. Prognostic performance significantly...
Tuberculosis (TB) is the leading cause of mortality from a single infectious agent, Mycobacterium tuberculosis Relevant immune targets partially efficacious TB vaccine bacille Calmette-Guérin (BCG) remain poorly defined. Mucosal-associated invariant T (MAIT) cells are MHC-related protein 1 (MR1)-restricted cells, which reactive against M. tuberculosis, and underexplored as potential targets. We sought to determine whether BCG vaccination activated mycobacteria-specific MAIT cell responses in...
BackgroundNon-protein antigen classes can be presented to T cells by near-monomorphic antigen-presenting molecules such as CD1, MR1, and butyrophilin 3A1. Such cells, referred donor unrestricted (DURT) typically express stereotypic cell receptors. The near-unrestricted nature of DURT recognition is particular interest for vaccine development, we sought define the roles including MR1-restricted MAIT CD1b-restricted glucose monomycolate (GMM)-specific CD1d-restricted NKT γδ in vaccination...
Infections related to neuromodulation devices such as spinal cord stimulators (SCS) and intrathecal pumps (ITPs) present complex challenges due potential complications localized infections, deep sepsis, neurological injury. Prompt diagnosis requires patients providers be educated on wound management sepsis symptoms for immediate medical attention. Antibiotic therapy duration vary based infection severity, with infections often requiring device removal despite recent improvements in salvage...
The bacille Calmette-Guérin (BCG) vaccine is usually administered at birth to protect against severe forms of tuberculosis in children. BCG also confers some protection other infections, possibly mediated by innate immune training. We investigated whether newborn vaccination modulates myeloid and natural killer (NK) cell responses mycobacteria.BCG was either or delayed 6 10 weeks age 130 South African infants. Whole blood stimulated with clusters differentiation (CD)4+ T, myeloid, NK were...
Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS) is an acute onset or exacerbation of symptoms following a group A streptococcus infection. It believed to be result response infection, but there insufficient evidence fully support this theory. Although disease primarily thought childhood, it reported occur also in adults. PANDAS well-defined clinical entity, the neuropathology condition has not been established yet. We describe course...
ABSTRACT Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently needed. We developed a robust simple, PCR-based host-blood transcriptomic signature, RISK6, multiple applications: identifying individuals at risk of incident disease, as screening test subclinical or clinical tuberculosis, treatment. RISK6 utility was validated by blind prediction using quantitative real-time (qRT) PCR in seven independent cohorts. Prognostic performance significantly...
Objectives. An 18-month prospective study serially tested healthcare workers (HCWs) for tuberculosis infection (TBI) and reported discordant QuantiFERON Gold In-Tube® (QFT) results in some participants. The purpose of the current was to investigate whether interferon-gamma (IFN- γ ) measured by QFT individuals could be influenced other circulating cytokines that vary seasonally at time phlebotomy. Methods. CDC funded TBESC Task Order 18 (TO18) project assess use Interferon Gamma Release...
Summary Antigen classes other than proteins can be presented to T cells by near-monomorphic antigen-presenting molecules such as CD1, MR1, and butyrophilin 3A1. We sought define the roles of donor unrestricted (DURT) cells, including MR1-reactive MAIT CD1b-reactive glucose monomycolate (GMM)-specific CD1d-reactive NKT γδ in vaccination against Mycobacterium tuberculosis . characterized DURT following primary bacille Calmette-Guerin (BCG) infants or BCG-revaccination adults. BCG...
Infants are highly susceptible to disease caused by infection with intracellular pathogens, such as Mycobacterium tuberculosis. The Bacille Calmette-Guerin (BCG) vaccine is usually administered at birth protect against severe forms of tuberculosis in children. BCG also has non-specific protective effects heterologous infections, thought be mediated enhanced innate cell functions. We aimed determine whether newborn vaccination modulates myeloid and NK responses mycobacteria. We enrolled...