A5100332790- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Glioma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- S100 Proteins and Annexins
- Cancer Immunotherapy and Biomarkers
- IL-33, ST2, and ILC Pathways
- Extracellular vesicles in disease
- Autoimmune Neurological Disorders and Treatments
- Ocular Oncology and Treatments
- Reproductive System and Pregnancy
- Atherosclerosis and Cardiovascular Diseases
- Peripheral Neuropathies and Disorders
- Protist diversity and phylogeny
- Epigenetics and DNA Methylation
- Complement system in diseases
- Protease and Inhibitor Mechanisms
- Phagocytosis and Immune Regulation
- Anesthesia and Neurotoxicity Research
- Myasthenia Gravis and Thymoma
- Lung Cancer Research Studies
Beijing Tian Tan Hospital
2025
Capital Medical University
2025
National Clinical Research Center for Digestive Diseases
2025
Second Affiliated Hospital of Harbin Medical University
2010-2024
Hangzhou Medical College
2022-2024
Zhejiang Provincial People's Hospital
2022-2024
Harbin Medical University
2010-2024
Cedars-Sinai Medical Center
2024
Chongqing Medical University
2022-2024
Columbia University
2024
Insulin-like growth factor 1 receptor (IGF1R) is a transmembrane that activated by insulin-like (IGF-1) and related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors plays an important role in colorectal cancer etiology progression. In this study, we used bioinformatic analyses search for miRNAs potentially target IGF1R. We identified specific sites miR-143 miR-145 (miR-143/145) 3′-untranslated region (3′-UTR) IGF1R gene. These are members cluster have been...
Mitochondrial oxidative stress (mitoOS) has been shown to be increased in various cell types human atherosclerosis and with aging. However, the role of type-specific mitoOS setting advanced age molecular mechanisms remains determined vivo.The aim this study was examine myeloid aged mice.Lethally irradiated low-density lipoprotein receptor-deficient mice (Ldlr-/-) were reconstituted bone marrow from either wild-type or mitochondrial catalase (mCAT) mice. mCAT transgenic contain ectopically...
Coagulopathy contributes to the majority of deaths and disabilities associated with traumatic brain injury (TBI). Whether neutrophil extracellular traps (NETs) contribute an abnormal coagulation state in acute phase TBI remains unknown. Our objectives were demonstrate definitive role NETs coagulopathy TBI. We detected NET markers 128 patients 34 healthy individuals. Neutrophil-platelet aggregates blood samples from individuals using flow cytometry staining for CD41 CD66b. Endothelial cells...
Abstract Aims Neutrophil extracellular traps (NETs) have been implicated in thrombotic diseases. There is no definitive explanation for how NETs form during acute ischemic strokes (AIS). The purpose of our study was to investigate the potential mechanism and role formation AIS process. Methods As well as 45 healthy subjects, patients with had ELISA tests performed detect NET markers. Expression high-mobility group box 1 (HMGB1) on platelet microvesicles (PMVs) analyzed by flow cytometry...
Exosomes are a new way of the communication between tumor cell and macrophage in micro-environment. The can be induced to different phenotypes according tumors. In present study, long-chain noncoding RNA HOTAIR (lncRNA HOTAIR) was highly expressed LSCC exosomes. pathway exosomal lncRNA inducing M2 polarization investigated. carcinoma tissues adjacent were collected from 104 cases, positive relationship CD163-/CD206-M2 infiltration clinical phase, lymph node spreading pathological phase...
Neutrophil extracellular traps (NETs) contribute to the creation of a coagulation state in various diseases. Currently, it is not clear whether NETs are present thrombi and plasma patients with cerebral venous sinus thrombosis (CVST). This study aimed investigate presence blood samples from CVST procoagulant activity (PCA) during progression CVST.Thrombi obtained undergoing thrombectomy were examined by immunochemistry using neutrophil elastase (NE), CD66b citrullinated histone H3(citH3)....
5-Methylcytosine (m5C) methylation is an important RNA modification pattern that can participate in oncogenesis and progression of cancers by affecting stability, expression oncogenes, the activity cancer signaling pathways. Alterations long non-coding RNAs (lncRNAs) are potentially correlated with abnormalities m5C regulation features cancers. Our aim was to reveal mechanisms which lncRNAs regulated process, explore impact aberrant on biological properties lower-grade gliomas (LGG),...
The heart rate variability (HRV) of patients with disorders consciousness (DOC) differs from healthy individuals. However, there is rarely research on HRV among DOC following treatment deep brain stimulation (DBS). This study aims to investigate the modulatory effects DBS-on central-autonomic nervous system based variations. We conducted DBS surgery eight DOC. Postoperatively, all underwent short-duration for 3 days, frequencies 25 Hz, 50 and 100 Hz respectively. Each day comprised four...
Background: A variety of regulatory approaches including immune modulation have been explored as to either eradicate antitumor response or induce suppressive mechanism in the glioblastoma microenvironment. Thus, study immune-related long noncoding RNA (lncRNA) signature is great value diagnosis, treatment, and prognosis glioblastoma. Methods: Glioblastoma samples with lncRNA sequencing corresponding clinical data were acquired from Cancer Genome Atlas (TCGA) database. Immune-lncRNAs...
Osteosarcoma is a primary solid bone malignancy, and surgery + chemotherapy the most commonly used treatment. However, chemotherapeutic drugs can cause range of side effects. Casticin, polymethoxyflavonoid, has anti-tumor therapeutic This study aim to investigate anti-osteosarcoma activity casticin explore mechanism. Crystal violet staining, MTT assay, colony formation wound healing transwell hoechst 33,258 flow cytometry analysis were effects on proliferation, migration, invasion, apoptosis...
Pigs are the most suitable model to study various therapeutic strategies and drugs for human beings, although knowledge about cell type-specific transcriptomes heterogeneity is poorly available. Through single-cell RNA sequencing flow cytometry analysis of types in jejunum pigs, we found that innate lymphoid cells (ILCs) existed lamina propria lymphocytes (LPLs) jejunum. Then, through sorting live/dead-lineage (Lin)-CD45+ sequencing, ILCs porcine were mainly ILC3s, with a small number NK...
This study aims to construct a Macrophage-Related Gene Prognostic Index (MRGPI) for glioblastoma (GBM) and explore the underlying molecular, metabolic, immunological features. Based on GBM dataset from The Cancer Genome Atlas (n = 156), 13 macrophage-related hub genes were identified by weighted gene co-expression network (WGCNA) analysis. 5 prognostic screened Kaplan-Meire (K-M) analysis Cox regression model used MRGPI, including GPR84, NCF2, HK3, LILRB2, CCL18. Multivariate found that...
Cancer-associated fibroblasts (CAFs) are vital components of prominent cellular in lower-grade gliomas (LGGs) that contribute to LGGs' progression, treatment resistance, and immunosuppression. Epigenetic modification immunity have significant implications for tumorigenesis development.We combined aberrant methylation CAFs abundances build a prognostic model the impact on biological properties LGGs. Grouping based median score samples TCGA-LGGs dataset, differentially expressed genes...
Clonal hematopoiesis (CH) increases inflammasome-linked atherosclerosis but the mechanisms by which CH mutant cells transmit inflammatory signals to non-mutant are largely unknown. To address this question we transplanted 1.5% Jak2VF bone marrow (BM) with 98.5% WT BM into hyperlipidemic Ldlr-/- mice. Low allele burden (LAB) mice showed accelerated increased features of plaque instability, decreased levels macrophage phagocytic receptors MERTK and TREM2, neutrophil extracellular traps (NETs)....
Anti-citrullinated protein antibodies (ACPAs) are highly specific for the diagnosis of rheumatoid arthritis (RA). However, about one-third RA patients negative ACPAs, which presents a challenge to early RA. The purpose this study was analyze differences in lymphocyte subsets and CD4 + T cell between ACPA - patients, evaluate value matrix metalloproteinase-3 (MMP-3) as diagnostic monitoring marker ACA patients. A total 145 38 healthy controls (HCs) were included study. Peripheral detected...
photodynamics therapy (PDT) induces tumor cell death through oxidative stress and is closely associated with the expression of hypoxia inducible factor-1a (HIF1a), which activates multiple downstream survival signaling pathways. Therefore, purpose this study was to investigate levels HIF1a proteins in PDT-treated GBM cells determine whether inhibition reduces signals enhance efficacy PDT. PDT combined Acriflavine (ACF, PA) decreased regulated GLUT-1, GLUT-3, HK2 other gluconeogenic pathway...