A5050173718- Hedgehog Signaling Pathway Studies
- Medicinal Plants and Neuroprotection
- Phytochemistry and Bioactivity Studies
- Phytoestrogen effects and research
- Phytochemical compounds biological activities
- Ferroptosis and cancer prognosis
- Congenital limb and hand anomalies
- Tumors and Oncological Cases
- Flavonoids in Medical Research
- Circular RNAs in diseases
- Connective Tissue Growth Factor Research
- Genomics, phytochemicals, and oxidative stress
- Cellular transport and secretion
- Ginger and Zingiberaceae research
- Cancer Mechanisms and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Total Knee Arthroplasty Outcomes
- Autophagy in Disease and Therapy
- Bone Metabolism and Diseases
- Bladder and Urothelial Cancer Treatments
- Orthopedic Infections and Treatments
- Phytochemical Studies and Bioactivities
- Berberine and alkaloids research
- Bone health and treatments
- Cancer, Lipids, and Metabolism
Children's Hospital of Chongqing Medical University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2024
Chongqing Medical University
2022-2024
Bladder cancer (BC) is the most common malignant tumor in urinary system. Although chemotherapy one of important adjuvant treatments for BC, drug resistance, non-specific toxicity and severe side effects are major obstacles to BC chemotherapy. Natural products have always been a leading resource antitumor discovery, with advantages excellent effectiveness, low toxicity, multi-targeting potency easy availability. In this study, we evaluated potential anti-tumor effect securinine (SEC),...
Bladder cancer (BC) is one of the most common malignant tumors in urinary system. Due to poor prognosis and high mortality rate disease, it urgent develop new drugs with efficacy low toxicity treat BC. Echinatin (Ecn) a bioactive natural flavonoid oflicorice that has attracted special attention for its promising anti-tumor potential. Herein, we explored inhibitory effects on BC cells probed possible molecular mechanism. We found Ecnin vitro inhibited proliferation, migration, invasion,...
Osteosarcoma is a primary solid bone malignancy, and surgery + chemotherapy the most commonly used treatment. However, chemotherapeutic drugs can cause range of side effects. Casticin, polymethoxyflavonoid, has anti-tumor therapeutic This study aim to investigate anti-osteosarcoma activity casticin explore mechanism. Crystal violet staining, MTT assay, colony formation wound healing transwell hoechst 33,258 flow cytometry analysis were effects on proliferation, migration, invasion, apoptosis...
Osteosarcoma (OS) is a primary malignant tumor of bone. Chemotherapy one the crucial approaches to prevent its metastasis and improve prognosis. Despite continuous improvements in clinical treatment OS, resistance remain dominant challenges. Macropinocytosis, form non-selective nutrient endocytosis, has received increasing attention as novel target for cancer therapy, yet role OS cells remains obscure. Benzethonium chloride (BZN) an FDA-approved antiseptic bactericide with broad-spectrum...
Background: Osteosarcoma is a highly invasive and early metastatic tumor. At present, the toxic side effects of chemotherapy affect quality life cancer patients to varying degrees. Genipin an extract natural medicine gardenia with various pharmacological activities. Objective: The purpose this study was investigate effect on osteosarcoma its potential mechanism action. Methods: Crystal violet staining, MTT assay colony formation were used detect genipin proliferation osteosarcoma. vitexin...
Bone morphogenetic protein 9 (BMP9) has remarkable potential to induce the differentiation of mesenchymal stem cells (MSCs) towards osteoblastic lineage. Additionally, research suggests that certain growth factors have ability potentiate BMP9-induced osteogenic MSCs. Sonic Hedgehog (Shh) plays an indispensable role in regulation skeletal development. The objective this was assess influence Shh on Our findings indicated effectively enhanced early and late MSCs, increased...
Amyloid precursor protein (APP), especially Swedish mutant APP (APPswe), is recognized as a significant pathogenic in Alzheimer's disease, but limited research has been conducted on the correlation between APPswe and osteogenic differentiation of mesenchymal stem cells (MSCs). The effects its intracellular extracellular segments bone morphogenetic 2 (BMP2)-induced MSCs were analyzed this study. Our analysis an existing database revealed that was positively correlated with negatively their...
Background With the arrival of era aging population, amount joint arthroplasty surgery keeps rising, and articles related to application tranexamic acid (TXA) in (we called as TIA this study) also show a blowout growth. Therefore, we conducted bibliometric analysis TIA-related publications identify main research trends hot spots field last 20 years. Methods In study, from January 1, 2002 December 31, 2021 were searched Web Science Core Collection (WoSCC). A total 1,013 evaluated for specific...
Osteosarcoma(OS) is a common primary malignant bone tumor, which mostly occurs in children and adolescents. Currently, chemotherapy drugs for the clinical treatment of OS have high side effects patients are prone to resistance, reduces therapeutic effect. Therefore, development new very important reduce toxicity adverse reactions improve survival rate patients. At present, antitumor activity traditional Chinese medicine monomers has received extensive attention because its safety efficacy....
Osteosarcoma (OS) is one of the most common types bone malignant tumors. Clinical commonly used therapeutic drugs OS treatment are prone to toxic and side effects, so it supposed develop new with low toxicity effects. As a Chinese traditional medicine, Neferine(C38H44N2O6) has inhibitory effects in various In present study, we investigated Nef on cells vitro vivo. We found that inhibited cell proliferation, reduced migration, decreased invasion, induced cycle arrest cells. Notably,...