A5026205723- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Myasthenia Gravis and Thymoma
- Neonatal Health and Biochemistry
- Sepsis Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Multiple and Secondary Primary Cancers
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Autophagy in Disease and Therapy
- Pituitary Gland Disorders and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Vascular Tumors and Angiosarcomas
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Immune Response and Inflammation
Zhejiang Cancer Hospital
2015-2024
Chinese Academy of Sciences
2022-2024
Sun Yat-sen University
2021-2023
Sun Yat-sen University Cancer Center
2021-2023
Hangzhou Cancer Hospital
2023
University of Chinese Academy of Sciences
2022
Abstract Our previous study revealed that PI3K/AKT/mTOR signaling was associated with SCLC radioresistance. SBC2 cells were used as primary radioresistance models, while H446 continuously exposed to ionizing radiation (IR) develop acquired Cell viability and apoptosis assays investigate synergistic effects of BEZ235/GSK2126458 IR in vitro, immunoblotting, metabolite quantitative analysis bioinformatic analyses utilized explore the underlying mechanism. Both genetically engineered mouse...
Abstract Background Thymic epithelial tumors (TETs) are rare malignant with limited treatment options. No established second‐line regimen is available following the preferred first‐line chemotherapy, resulting in unsatisfactory efficacy and poor prognosis for patients advanced TETs. This study aimed to evaluate of small molecule multitarget antiangiogenic inhibitors as well prognostic factors Methods A retrospective was conducted using data from a real‐world database. Clinical information...
Interleukin 1 receptor-associated kinase 2 (IRAK2) plays a critical role in immune response by participating the formation of Myddosome complex Toll-like receptor (TLR) signaling pathways. Here, we identified loss-of-function mutation (IRAK2-∆ex2) IRAK2 gene three patients, presenting with dysregulation, including systemic lupus erythematosus (SLE) and Behcet's disease. This leads to skipping exon IRAK2, disrupting its interaction IRAK4 impairing activation nuclear factor kappa B (NF-𝜅B)...
802 Background: Prior studies indicated that polymerase epsilon/polymerase delta (POLE/POLD1) exonuclease domain mutations (POL-EDMs) was associated with the efficacy of immune checkpoint inhibitor (ICI). However, there remains controversy about whether patients POLE/POLD1 non-exonuclease (POLE-non-EDMs), which occupied majority mutations, could benefit from ICI. Currently, few prospective clinical trials have evaluated predictive value mutation in Methods: We initiated a phase II trial for...
e15555 Background: Synchronous colorectal cancer (SCRC) refers to a special group of CRC with at least two primary tumors detected simultaneously in one patient, 90% being sporadic. Although the systemic treatments late-stage SCRC are mainly based on molecular testing lesion, this might not be representable other and metastatic lesions. This study aimed investigate features genetic heterogeneity sporadic order guide clinical practice. Methods: We retrospectively collected all tumor samples...
Abstract Background: The prognostic value of lactate dehydrogenase (LDH) in colorectal cancer patients has remained inconsistent between non-metastatic and metastatic settings. So far very few studies have included LDH analysis for with liver metastases (CRLM) who underwent curative-intent hepatectomy. Patients Methods: Consecutive resection CRLM from two Chinese medical centers treated 2000-2019 were enrolled the training cohort (434 patients) validation (146 patients). Overall survival...