A5057247020- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- HIV Research and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- ATP Synthase and ATPases Research
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory mediators and NSAID effects
- interferon and immune responses
- Receptor Mechanisms and Signaling
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Colorectal and Anal Carcinomas
- Esophageal Cancer Research and Treatment
- Metal complexes synthesis and properties
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Extracellular vesicles in disease
- RNA Research and Splicing
- Health Systems, Economic Evaluations, Quality of Life
Sun Yat-sen University Cancer Center
2018-2025
Sun Yat-sen University
2018-2025
State Key Laboratory of Oncology in South China
2019-2023
Northwestern University
2001-2003
Georgia Institute of Technology
1997
Background and objective Gastric cancer (GC) remains a prevalent preventable disease, yet accurate early diagnostic methods are lacking. Exosome non-coding RNAs (ncRNAs), type of liquid biopsy, have emerged as promising biomarkers for various tumours. This study aimed to identify serum exosome ncRNA feature enhancing GC diagnosis. Designs Serum exosomes from patients with (n=37) healthy donors (n=20) were characterised using RNA sequencing, potential validated through quantitative reverse...
Background: Tumor mutational burden (TMB) has been widely studied as a predictive biomarker of response to immune checkpoint inhibitors (ICIs). Besides, evidence suggests frameshift indels are highly immunogenic class and thus potentially superior biomarker. However, the general prognostic impact TMB indel in patients with solid tumors not systematically investigated. Methods: We analyzed 20 primary cancer types from The Cancer Genome Atlas (TCGA) database. Clinicopathologic factors, were...
Abstract The acidic tumor microenvironment provides an energy source driving malignant progression. Adaptation of cells to environment leads the emergence cancer stem cells. expression vitamin D receptor (VDR) is closely related initiation and development colorectal carcinoma (CRC), but its regulatory mechanism in CRC still unclear. Our study revealed that acidosis reduced VDR by downregulating peroxisome proliferator-activated delta (PPARD) expression. Overexpression effectively suppressed...
Abstract Background A critical and challenging process in immunotherapy is to identify cancer patients who could benefit from immune checkpoint inhibitors (ICIs). Exploration of predictive biomarkers help maximize the clinical benefits. Eph receptors have been shown play essential roles tumor immunity. However, association between EPH gene mutation ICI response lacking. Methods Clinical data whole-exome sequencing (WES) published studies were collected consolidated as a discovery cohort...
Sidedness (right/left) of colorectal cancer (CRC) is essential for treatment. Whether carcinogenesis tobacco varies by sidedness remains unclear. The present study aims to evaluate the tendency cigarette smoking and explore its impact on prognosis.
Abstract Colorectal adenomas (CRAs) represent precancerous lesions that precede the development of colorectal cancer (CRC). Regular monitoring CRAs can hinder progression into carcinoma. To explore utility tissue DNA and circulating cell‐free (cfDNA) in early diagnosis CRC, we retrospectively sequenced paired plasma samples from 85 patients with conventional CRAs. The genetic alterations identified were compared those 78 stage‐I CRC (CRC‐I) ChangKang project. Within CRA cohort, pinpointed 12...
Background: The benefit of palliative gastrectomy for patients with metastatic gastric cancer (mGC) is controversial, and suitable candidates surgery treatment strategies remain unclear. present study aimed to investigate the efficacy plus chemotherapy among mGC identify potential such using real-world data. Methods: A dataset 236 diagnosed at Sun Yat-Sen University Cancer Center from January 1, 2006 December 31, 2012 were analyzed retrospectively. cohort comprised 80 who had (SC) 156 only...
Sporadic synchronous colorectal cancer (SCRC) refers to multiple primary CRC tumors detected simultaneously in an individual without predisposing hereditary conditions, which accounts for the majority of CRCs while lacking a profound understanding genomic landscape and evolutionary dynamics optimize its treatment. In this study, 103 tumor samples from 51 patients with SCRC undergo whole-exome sequencing. The germline somatic mutations clinical features are comprehensively investigated....
Objective:The purpose of this prospective study was to investigate the perceptions and attitudes participate in radical palliative clinical trials among Chinese lymphoma head/neck cancer patients.Patients Methods: A self-developed questionnaire administered hospitalized patients Department Medical Oncology Sun Yat-Sen University Cancer Center between 20 September 2014 2015.This included who were enrolled into a treatment trial, participating trial.Results: There 136 87 completed returned...
649 Background: It is reported that sidedness (right vs. left) and histology (mucinous non-mucinous) of CC predictive survival. We investigated whether the prognostic values were affected by each other. Methods: identified 81342 patients with stage II–IV between 2004 2012 from Surveillance, Epidemiology, End Results database. Inverse probability propensity score weighting was used to balance clinical features (i.e., age, sex, race, marital status, year diagnosis, registry, tumor grade, T N...
e15555 Background: Synchronous colorectal cancer (SCRC) refers to a special group of CRC with at least two primary tumors detected simultaneously in one patient, 90% being sporadic. Although the systemic treatments late-stage SCRC are mainly based on molecular testing lesion, this might not be representable other and metastatic lesions. This study aimed investigate features genetic heterogeneity sporadic order guide clinical practice. Methods: We retrospectively collected all tumor samples...