A5084067884- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Genomics and Phylogenetic Studies
- Toxin Mechanisms and Immunotoxins
- Genetic factors in colorectal cancer
- Genetics, Bioinformatics, and Biomedical Research
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Viral-associated cancers and disorders
- Ginseng Biological Effects and Applications
- Molecular Biology Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Ferroptosis and cancer prognosis
- Bioinformatics and Genomic Networks
- Machine Learning in Bioinformatics
- Lung Cancer Treatments and Mutations
- Mycobacterium research and diagnosis
Nanjing University of Chinese Medicine
2024
Jiangsu Province Hospital
2024
Sun Yat-sen University
2021-2023
Sun Yat-sen University Cancer Center
2021-2023
Abstract The visualization of biological sequences with various functional elements is fundamental for the publication scientific achievements in field molecular and cellular biology. However, due to limitations currently used applications, there are still considerable challenges preparation schematic diagrams. Here, we present a professional tool called IBS 2.0 illustrating organization both protein nucleotide sequences. With abundant graphical provided 2.0, can be easily represented...
BackgroundThe ginseng polysaccharide injection is a well-known traditional Chinese medicine often employed as supplementary treatment for cancer. This can not only alleviate the adverse effects caused by tumor radiotherapy and chemotherapy but also enhance immune system of individuals diagnosed with lung It important to acknowledge efficacy in non-small cell cancer (NSCLC). However, these small-sample studies may have certain biases, underlying mechanisms polysaccharides therapy NSCLC are...
802 Background: Prior studies indicated that polymerase epsilon/polymerase delta (POLE/POLD1) exonuclease domain mutations (POL-EDMs) was associated with the efficacy of immune checkpoint inhibitor (ICI). However, there remains controversy about whether patients POLE/POLD1 non-exonuclease (POLE-non-EDMs), which occupied majority mutations, could benefit from ICI. Currently, few prospective clinical trials have evaluated predictive value mutation in Methods: We initiated a phase II trial for...
Background While recent studies have separately explored mutational signatures and the tumor microenvironment (TME), there is limited research on associations of both factors in a pan-cancer context. Materials methods We performed analysis over 8,000 samples from The Cancer Genome Atlas (TCGA) project. Machine learning were employed to systematically explore relationship between TME develop risk score based TME-associated predict patient survival outcomes. also constructed an interaction...
Abstract The quality control of cancer somatic mutations is an essential step for eliminating false positive from technical bias, and selecting key mutation candidates plays a crucial role in both downstream translation research personal medical decisions. Existing tools, with complicated parameters changeable filtering standards, may not be suitable specifically mutations. In addition, previous genomic studies usually adopted different criteria processing raw sequencing datasets, which...
e15555 Background: Synchronous colorectal cancer (SCRC) refers to a special group of CRC with at least two primary tumors detected simultaneously in one patient, 90% being sporadic. Although the systemic treatments late-stage SCRC are mainly based on molecular testing lesion, this might not be representable other and metastatic lesions. This study aimed investigate features genetic heterogeneity sporadic order guide clinical practice. Methods: We retrospectively collected all tumor samples...